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ABO Blood Groups Associations with Ovarian Cancer: A Systematic Review and Meta-analysis

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Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Background

Ovarian Cancer (OC), as the seventh most common cancer throughout the world, is one of the most lethal gynecologic malignancies in women. In addition to well-studied risk and prognostic factors of OC, such as age, obesity, stage, histology, etc., ABO blood groups associations with OC has been attracted the investigators’ focus in the recent decade. The objective of this study is to find any relationships between ABO blood groups and OC through a meta-analysis.

Methods

The databases of PubMed, Embase, and Web of Science were systematically searched by available MeSh terms for “Ovarian Cancer”, and “ABO blood group” up to August 1, 2020. Hazard ratio (HR) or odds ratio (OR) were extracted and used from studies for outcome estimation whenever appropriate with 95% confident interval (CI). Data were analyzed using CMA v. 2.2.064.

Results

Fourteen papers, including 58,193 participants, entered in the systematic review. The meta-analysis indicated a substantially higher risk of developing OC in individuals with blood group A (OR 1.17, 95% CI 1.01–1.36) and AB (OR 1.27, 95% CI 1.02–1.59), but the subject was not significant in individuals with blood group B (OR 1.11, 95% CI 0.81–1.51). No associations were found between OC overall survival and blood group A (HR 1.14, 95% CI 0.79–1.64), AB (HR 1.00, 95% CI 0.69–1.45), and B (HR 0.88, 95% CI 0.58–1.33). Recurrence rates of OC for blood groups A, AB, B, and O were 30.8%, 34.3%, 33.6%, and 32.0%, respectively. Rates of mortality in different blood groups are as follows: A (31.8%), AB (31.1%), B (26.2%), and O (33.8%).

Conclusion

This systematic review and meta-analysis revealed a considerably increased risk of developing OC among individuals with blood group A and AB. However, no substantial impacts were found for ABO blood groups on the overall survival of the OC patients.

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Availability of Data and Materials

Data are available through online databases and references of the current study.

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Authors and Affiliations

  1. Laboratory Sciences Research Centre, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

    Nazanin Razzaghi

  2. Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

    Houman Seraj

  3. Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran

    Keyvan Heydari

  4. Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Keyvan Heydari, Alireza Salehi & Mohammad Malekan

  5. Department of Internal Medicine, Imam Khomeini Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Hossein Azadeh

  6. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

    Morteza Behnamfar

  7. Student Research Committee, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran

    Mahsa Bahadori

  8. Student Research Committee, Shahrood Branch, Islamic Azad University, Shahrood, Iran

    Hanie Ebrahimi

  9. Department of Obstetrics and Gynecology, Reproductive Health Research Center, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran

    Negar Gholamalipour

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  1. Nazanin Razzaghi
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Razzaghi, N., Seraj, H., Heydari, K. et al. ABO Blood Groups Associations with Ovarian Cancer: A Systematic Review and Meta-analysis. Indian J Gynecol Oncolog 18, 112 (2020). https://doi.org/10.1007/s40944-020-00463-y

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  • DOI: https://doi.org/10.1007/s40944-020-00463-y

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