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Case–Control Study to Find Association of Common RTIs with CIN and Cervical Cancer

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Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Objectives

To find the association of common RTIs (bacterial vaginosis, Trichomonas vaginalis, N. gonorrhoeae and Candida albicans) in causing pre-invasive and invasive lesions of the cervix.

Methods

This hospital-based cross-sectional case-control study was conducted in 219 subjects over a period of 1 year. In total, 100 cases (51 CIN + cervical cancer) and 119 controls underwent screening for common RTIs through cervical and vaginal swabs.

Results

RTI incidence was significantly higher (p = 0.003) in CIN, but not in cervical cancer cases (p = 0.399). Among various RTIs, bacterial vaginosis was significantly associated (p < 0.001) with CIN. Other RTIs did not show any statistically significant association with CIN or cervical cancer.

Conclusion

The coexistence of bacterial vaginosis is a risk factor for pre-invasive lesions of the cervix. Thus, prompt diagnosis and treatment of BV may help in reducing the risk of persistence of HPV infection and progression to pre-invasive lesions of the cervix.

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Acknowledgments

We acknowledge the participation of all women included as study subjects.

Funding

Nil.

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Authors and Affiliations

  1. King George’s Medical University, Lucknow, Uttar Pradesh, India

    Radha Gupta, Nisha Singh, Raj Kumar Kalyan & Shuchi Agrawal

Authors
  1. Radha Gupta
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  2. Nisha Singh
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  3. Raj Kumar Kalyan
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  4. Shuchi Agrawal
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Contributions

Nisha Singh conceptualized the study. Radha Gupta collected the data, analyzed them and prepared the report. RK Kalyan conducted the laboratory tests. Radha Gupta and Shuchi Agrawal prepared the manuscript draft. Nisha Singh reviewed and finalized the submitted version.

Corresponding author

Correspondence to Shuchi Agrawal.

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Conflict of interest

There are no relationships (for any author) that may be deemed to influence the objectivity of the paper and its review. There are no commercial associations, either directly or through immediate family, in areas such as expert testimony, consulting, honoraria, stock holdings, equity interest, ownership, patent-licensing situations or employment that might pose a conflict of interest. There are no conflicts for other reasons, such as personal relationships or academic competition.

Ethical approval

Ethical approval was obtained from the Institutional Ethics Committee.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Consent to publish

Additional informed consent was obtained from all participants for whom identifying information is included in the study.

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Gupta, R., Singh, N., Kalyan, R.K. et al. Case–Control Study to Find Association of Common RTIs with CIN and Cervical Cancer. Indian J Gynecol Oncolog 18, 116 (2020). https://doi.org/10.1007/s40944-020-00460-1

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  • DOI: https://doi.org/10.1007/s40944-020-00460-1

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