Skip to main content

Advertisement

SpringerLink
Log in

Clinical Evaluation of Atypical Glandular Cells Detected on Cervical Cytological Examination in a Tertiary Hospital

  • Original Article
  • Published:
Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Introduction

Evaluation of cervical cytology by Papanicolaou smear has assumed great importance in diagnosis of premalignant lesions of the cervix. One of the entities encountered infrequently on cervical cytology is atypical cells of glandular origin.

Materials and Method

An observational prospective study was conducted in the Department of Obstetrics and Gynaecology in Deen Dayal Upadhyay hospital over a period of 2 years, from August 2014 to August 2016. All the OPD or indoor patients who had a report of AGC-NOS Pap smear were evaluated for their socio-demographic profile and presence of risk factors. They were managed as per ASCCP guidelines. Statistical analysis was done by Chi-square test.

Result

A total of 3479 pap smears were reviewed in 2-year time period; out of which 77 (2.2%) were AGC and 24 (0.7%) smears had AGC with ASCUS. AGC was reported most commonly in perimenopausal age group (40–50 years) and was much more common in multiparous women (94%). The incidence of high-grade disease was significantly higher in women with AGC with ASCUS (37.5%) as compared to women with AGC (20%). The occurrence of cervicitis in women with AGC alone was significantly higher than those with AGC along with ASCUS.

Conclusion

AGC-NOS may represent a myriad of benign and malignant lesions and warrants a complete evaluation. Complete treatment of causative benign lesions is warranted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Solomon D, Davey D, Kurman R. The 2001 Bethesda system. JAMA. 2002;287:2114–9.

    Article  Google Scholar 

  2. Ribeiro VC, Correia L, Aguilar S, Paula T, Borrego J. Clinical implication of atypical glandular cells; a five year experience of a single institution in Portugal. Gynecol Obstet. 2015;5:311. https://doi.org/10.4172/2161-0932.1000311.

    Article  Google Scholar 

  3. Pradhan D, Li Z, Ocque R, Patadji S, Zhao C. Clinical significance of atypical glandular cells in Pap tests: an analysis of more than 3000 cases at a large academic women’s center. Cancer Cytopathol. 2016;124(8):589–95. https://doi.org/10.1002/cncy.21724.

    Article  PubMed  Google Scholar 

  4. Zhao C, Florea A, Onisko A, Austin RM. Histologic follow-up results in 662 patients with Pap test findings of atypical glandular cells: results from a large academic womens hospital laboratory employing sensitive screening methods. Gynecol Oncol. 2009;114(3):3839.

    Article  Google Scholar 

  5. Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain J, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. CA Cancer J Clin. 2012;62(3):147–72.

    Article  Google Scholar 

  6. Holanda Marques JP, Costa LB, Pinto APDS, de Lima AF, Duarte MEL, Barbosa APF, de Medeiros PL. Atypical glandular cells and cervical cancer: systematic review. Rev Assoc Med Bras. 2011;57(2):229–33.

    Article  Google Scholar 

  7. Adhya AK, Mahesha V, Srinivasan R, Nijhawan R, Rajwanshi A, Suri V, Dhaliwal LK. Atypical glandular cells in cervical smears: histological correlation and a suggested plan of management based on age of the patient in a low-resource setting. Cytopathology. 2009;20(6):375–9.

    Article  CAS  Google Scholar 

  8. Asciutto KC, Henic E, Forslund O, Bjelkenkrantz K, Borgfeldt C. Age influences the clinical significance of atypical glandular cells on cytology. Anticancer Res. 2015;35(2):913–9.

    PubMed  Google Scholar 

  9. Ludwin A, Ludwin I, Pityński K, Jach R, Banaś T, Stangel-Wojcikiewicz K, Horbaczewska A, Pietrus M. Prevalence of HPV-DNA in Pap smears containing ASC and AGC performed within population programme of prophylaxis and early detection of early cervical cancer. Przegl Lek. 2012;69(11):1189–93.

    PubMed  Google Scholar 

  10. Naidu MSK, Suryakar AN, Swami SC, Katkam RV, Kumbar KM. Oxidative stress and antioxidant status in cervical cancer patients. Indian J Clin Biochem. 2007;22(2):140–4. https://doi.org/10.1007/bf02913333.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Jiangrong W, Bengt A, Karin S, Peter S, Alexander P, Miriam E, et al. Risk of invasive cervical cancer after atypical glandular cells in cervical screening: nationwide cohort study. BMJ. 2016;352:i276.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Deen Dayal Upadhyay Hospital, Hari Nagar, New Delhi, Delhi, 110064, India

    Urvashi Miglani, Poonam Laul, Neha Bansal & Neeta Bindal

  2. Sir Gangaram Hospital, New Delhi, India

    Sanjeev Miglani

Authors
  1. Urvashi Miglani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Poonam Laul
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Neha Bansal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Neeta Bindal
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sanjeev Miglani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Urvashi Miglani.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miglani, U., Laul, P., Bansal, N. et al. Clinical Evaluation of Atypical Glandular Cells Detected on Cervical Cytological Examination in a Tertiary Hospital. Indian J Gynecol Oncolog 17, 59 (2019). https://doi.org/10.1007/s40944-019-0302-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s40944-019-0302-5

Keywords

Search

Navigation