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Endometrial Carcinoma in Young Women: Single-Center Experience

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Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Objective

The purpose of this retrospective study was to describe our experience in the management of endometrial carcinoma in young women aged 40 years and younger at a tertiary care oncology institute in India.

Materials and Methods

Clinical and histopathological data of 22 patients out of 362 cases of endometrial cancer operated between 2008 and 2015 were analyzed.

Results

Twenty-two women aged ≤ forty years were operated at our hospital for endometrial cancer. The mean age at diagnosis was 35 (range 15–40 years); 89.5 % of the women were premenopausal. The mean BMI was 24.6 kg/m2. Seventeen cases were detected at stage I, 2 in stage II and 3 in stage III. Lymphatic spread was seen only in one case. Ovarian metastases were seen in 2 cases. Eight patients were kept on observation, and the rest were given adjuvant therapy.

Conclusion

Our study represents a small cohort of endometrial cancer patients aged 40 years or younger treated at a single institution with a high incidence of obesity, nulliparity and irregular menstrual cycles. These findings suggest that there may be an important role of hormonal imbalance. The combination of abnormal uterine bleeding and obesity or a history of infertility should raise a suspicion of endometrial cancer.

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References

  1. Balasubramaniam G, Sushama S, Rasika B, Mahantshetty U. Hospital-based study of endometrial cancer survival in Mumbai, India. Asian Pac J Cancer Prev. 2013;14:977–80.

    Article  PubMed  Google Scholar 

  2. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008, cancer incidence and mortality worldwide: IARC Cancer Base No. 10. Lyon: International Agency for Research on Cancer; 2008.

  3. Ota T, Yoshida M, Kimura M, Kinoshita K. Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger. Int J Gynecol Cancer. 2005;15(4):657–62.

    Article  CAS  PubMed  Google Scholar 

  4. Uharcˇek P, Mlyncˇek M, Ravinger J, Matejka M. Prognostic factors in women 45 years of age or younger with endometrial cancer. Int J Gynecol Cancer. 2008;18:324–8.

    Article  Google Scholar 

  5. Duska LR, Garrett A, Rueda BR, Haas J, Chang Y, Fuller AF. Endometrial cancer in women 40 years old or younger. Gynecol Oncol. 2001;83(2):388–93.

    Article  CAS  PubMed  Google Scholar 

  6. Thomas CC, Wingo PA, Dolan MS, Lee NC, Richardson LC. Endometrial cancer risk among young, overweight women. Obstet Gynecol. 2009;114:22–7.

    Article  PubMed  Google Scholar 

  7. Soliman PT, Oh JC, Schmeler KM, Sun CC, Slomovitz BM, Gershenson DM, Burke TW, Karen H. Risk factors for young premenopausal women with endometrial cancer. Obstet Gynecol. 2005;105:575–80.

    Article  PubMed  Google Scholar 

  8. Dubeau L. Etiology and detection of gynecologic cancers. In: Morrow CP, Curtin JP, Townsend DE, editors. Synopsis of gynecologic oncology. 4th ed. New York: Churchill Livingstone; 1993. p. 1–22.

    Google Scholar 

  9. Parslov M, Lidegaard O, Klintorp S, Pedersen B, Jonsson L, Eriksen PS, et al. Risk factors among young women with endometrial cancer: a Danish case-control study. Am J Obstet Gynecol. 2000;182:23–9.

    Article  CAS  PubMed  Google Scholar 

  10. Clinical guidelines on the identification,evaluation and treatment of overweight and obesity in adults: the evidence report. National Institute of Health Obes Res. 1998;6 suppl:51S–209S.

  11. FIGO, Staging and classification and clinical practice guidelines of gynecologic cancers by the FIGO committee on gynecologic oncology. Oxford: Elsevier, 2000.

  12. Scully RE, Young RH, Clement PB. Tumours of the ovary, maldeveloped gonads, fallopian tube and broad ligament: Atlas of tumour pathology. Bethesda: Armed Forces Institute of Pathology; 1998.

    Google Scholar 

  13. Singh M. Early age of natural menopause in India: a biological marker for early preventive health programs. Climacteric. 2012;15(6):581–6.

    Article  CAS  PubMed  Google Scholar 

  14. Tran BN, Connell PP, Waggoner S, Rotmensch J, Mundt AJ. Characteristics and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin Oncol. 2000;23:476–80.

    Article  CAS  PubMed  Google Scholar 

  15. Helpman L, Kupets R, Covens A, et al. Assessment of endometrial sampling as a predictor of final surgical pathology in endometrial cancer. Br J Cancer. 2014;110:609–15.

    Article  CAS  PubMed  Google Scholar 

  16. Chiang Y-C, Chen C-A, Huang C-Y, Hsieh C-Y, Cheng W-F. Synchronous primary cancers of the endometrium and ovary. Int J Gynecol Cancer. 2008;18:159–64.

    Article  PubMed  Google Scholar 

  17. Lau Hei-Yu, Twu N-F, Yen M-S, et al. Impact of ovarian preservation in women with endometrial cancer. J Chin Med Assoc. 2014;77(7):379–84.

    Article  PubMed  Google Scholar 

  18. Ben-Arie A, Perlman S, Hazan Y, et al. High-risk endometrial cancer in young indigent women. Int J Gynecol Cancer. 2004;14:927–30.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gynaec-Oncology, Gujarat Cancer and Research Institute, E-102, Neelkanth Park-2, Near BSNL Office, Ghoda Camp Road, Shahibaug, Ahmedabad-16, India

    Anusha Kamath

  2. Department of Gynae-Oncology, Gujarat Cancer and Research Institute, Civil Hospital Campus, Asarwa, Ahmedabad-16, India

    Meeta Mankad, Pariseema Dave, Shilpa Patel, Ava Desai & Ruchi Arora

Authors
  1. Anusha Kamath
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  2. Meeta Mankad
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  3. Pariseema Dave
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  4. Shilpa Patel
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  5. Ava Desai
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  6. Ruchi Arora
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Corresponding author

Correspondence to Anusha Kamath.

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Kamath, A., Mankad, M., Dave, P. et al. Endometrial Carcinoma in Young Women: Single-Center Experience. Indian J Gynecol Oncolog 14, 49 (2016). https://doi.org/10.1007/s40944-016-0076-y

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  • DOI: https://doi.org/10.1007/s40944-016-0076-y

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