Skip to main content

Advertisement

Log in

Uterine Undifferentiated Sarcoma Associated with Primary Adenocarcinoid of Ileum: an Unusual Second Primary Malignancy with Therapeutic Implications

  • Case report
  • Published:
Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Purpose

Uterine sarcomas and small bowel neuroendocrine tumours are both uncommon neoplasms. We report the case of a patient affected by an undifferentiated uterine sarcoma and synchronous adenocarcinoid of the ileum, in which surgery played a key role.

Methods

A 57-year-old postmenopausal woman presented with a 6-month history of pelvic pain and uterine bleeding. Examination revealed a polypoid mass of 15 mm in diameter protruding from external os. Abdomino-pelvic MRI identified another solid nodule of 20 mm in diameter in the ileal wall.

Results

Histology demonstrated an undifferentiated uterine sarcoma. However, the ileal nodule proved to be an adenocarcinoid and not a metastatic deposit of the uterine malignancy.

Conclusions

Histological evaluation of uncertain lesions may help in providing appropriate treatment and hence, a better survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Harlow BL, Weiss NS, Lofton S. The epidemiology of sarcomas of the uterus. J Natl Cancer Inst. 1986;76:399–402.

    CAS  PubMed  Google Scholar 

  2. Ashraf-Ganjoei T, Behtash N, Shariat M, Mosavi A. Low grade endometrial stromal sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases. World J Surg Oncol. 2006;4:50.

    Article  PubMed  PubMed Central  Google Scholar 

  3. World Health Organization classification of tumours. In: Tavassoli FA, Devilee P, editors. Pathology and genetics of tumours of the breast and female genital organs. Lyon: IARC Press; 2003.

  4. Ramondetta L, Bodurka D, Deavers M, Jhingran A. Uterine sarcomas. In: Eifel PJ, Gershenson DM, Kavanagh JJ, Silva EG, editors. M. D. Anderson Cancer Care Series, Gynecologic Cancer. New York: Springer; 2006. p. 125–47.

    Google Scholar 

  5. Tanner EJ, Garg K, Leitao MM, Soslow RA, Hensley ML. High grade undifferentiated uterine sarcoma: surgery, treatment, and survival outcomes. Gynecol Oncol. 2012;127(1):27–31.

    Article  PubMed  Google Scholar 

  6. Prat J. FIGO staging for uterine sarcomas. Int J Gynaecol Obstet. 2009;104:177–78.

    Article  PubMed  Google Scholar 

  7. Bosman FT, Carneiro F, Hruban RH, Theise ND (editors). WHO classification of tumours of the digestive system. Lyon: International Agency for Research on cancer Lyon (IARC) Press; 2010.

  8. Irvin Modlin M, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934–59.

    Article  PubMed  Google Scholar 

  9. Gadducci A, Sartori E, Landoni F, Zola P, Maggino T, Urgesi A, Lissoni A, Losga Gand Fanucci A. Endometrial stromal sarcoma: analysis of treatment failures and survival. Gynecol Oncol. 1996;63:247–53.

    Article  CAS  PubMed  Google Scholar 

  10. Kanjeekal S, Chambers A, Fung MF, Verma S. Systemic therapy for advanced uterine sarcoma: a systematic review of the literature. Gynecol Oncol. 2005;97:624–37.

    Article  CAS  PubMed  Google Scholar 

  11. Leath CA III, Huh WK, Hyde J Jr, Cohn DE, Resnick KE, Taylor NP, et al. A multi-institutional review of outcomes of endometrial stromal sarcoma. Gynecol Oncol. 2007;105:630–4.

    Article  PubMed  Google Scholar 

  12. Zagouril F, Dimopoulos AM, Fotiou S, Kouloulias V, Papadimitriou CA. Treatment of early uterine sarcomas: disentangling adjuvant modalities. World J Surg Oncol. 2009;7:38.

    Article  Google Scholar 

  13. Sutton R, Doran HE, Williams EM, Vora J, Vinjamuri S, Evans J, Campbell F, Raraty MG, Ghaneh P, Hartley M, Poston GJ, Neoptolemos JP. Surgery for midgut carcinoid. Endocr Relat Cancer. 2003;10:469–81.

    Article  CAS  PubMed  Google Scholar 

  14. Scèlo G, Boffetta P, Hemminki K, Pukkala E, Olsen JH, Andersen A, Tracey E, Brewster DH, McBride ML, Kliewer EV, Tonita JM, Pompe-Kirn V, Chia KS, Jonasson JG, Martos C, Colin D, Brennan P. Associations between small intestine cancer and other primary cancers: An international population-based study. Int J. Cancer. 2006;118:189–96.

    Article  PubMed  Google Scholar 

  15. Habal N, Sims C, Bilchik AJ. Gastrointestinal carcinoid tumors and second primary malignancies. J Surg Oncol. 2000;75:310–6.

    Article  CAS  PubMed  Google Scholar 

  16. Kaltas G, Korbonits M, Heintz E, Mukherjee JJ, Jenkins PJ, Chew SL, Reznek R, Monson JP, Besser GM, Foley R, Britton KE, Grossman AB. Comparison of somatostatin analog and meta-iodobenzylguanidine radionuclides in the diagnosis and localization of advanced neuroendocrine tumors. J Clin Endocrinol Metab. 2001;86:895–902.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Irene Pecorella.

Ethics declarations

Conflict of interest

All the Authors deny any financial competing interest in this manuscript.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pecorella, I., Faiano, P., Ciardi, G. et al. Uterine Undifferentiated Sarcoma Associated with Primary Adenocarcinoid of Ileum: an Unusual Second Primary Malignancy with Therapeutic Implications. Indian J Gynecol Oncolog 13, 12 (2015). https://doi.org/10.1007/s40944-015-0019-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s40944-015-0019-z

Keywords

Navigation