Skip to main content
SpringerLink
Log in

Clinicopathological Perspectives on Endometrioid Epithelial Ovarian Carcinoma in Indian Women

  • Published:
Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Purpose

To analyse cases of endometrioid epithelial ovarian carcinoma with respect to clinicopathological features, management and outcome at a tertiary cancer referral hospital in western India.

Methods

This is a retrospective analysis of 46 cases treated at the Gujarat Cancer & Research Institute from January 2008–September 2012. Baseline characteristics, CA-125, RMI, management, staging, grading, residual disease, adjuvant therapy and survival were studied and analysed, using SPSS 22.0 software. Non-parametric tests for statistical significance and Kaplan–Meier survival analysis were applied.

Results

Out of 46 women (median age 50 years), 39 % were diagnosed in early stage, 24 % in advanced stage and 37 % were unstaged. Overall survival at 24 months was 87.8 %. It was associated with infertility (28 %), endometriosis (9 %) and synchronous endometrial carcinoma (20 %). R0 resection was achieved in 74 % of patients.

Conclusions

The univariate analysis showed that size of tumour, disease stage and R0 resection status were significant prognostic factors for endometrioid subtype of epithelial ovarian cancer. Endometrioid epithelial ovarian cancer was associated with synchronous endometrial carcinoma, nulliparity and younger age at presentation. NACT with interval cytoreduction (in patients with clinically advanced tumours where R0 resection may be unfeasible) can offer survival benefits equivalent to primary cytoreduction (in advanced stage).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Barakat RR, Markman M, Randall M. Principles and practice of gynecologic oncology. Philadelphia: Lippincott Williams & Wilkins; 2009.

    Google Scholar 

  2. Storey DJ, Rush R, Stewart M, Rye T, Al-Nafussi A, Williams AR, et al. Endometrioid epithelial ovarian cancer. Cancer. 2008;112(10):2211–20.

    Article  PubMed  Google Scholar 

  3. Jonathan S, Berek NFH. Berek and Hacker’s gynecologic oncology. 6th ed. Philadelphia: Wolters Kluwer; 2014.

    Google Scholar 

  4. Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas–a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83(2):355–62.

    Article  CAS  PubMed  Google Scholar 

  5. Silva EG, Young RH. Endometrioid neoplasms with clear cells: a report of 21 cases in which the alteration is not of typical secretory type. Am J Surg Pathol. 2007;31(8):1203–8.

    Article  PubMed  Google Scholar 

  6. Gupta D, Lis CG. Role of CA125 in predicting ovarian cancer survival—a review of the epidemiological literature. J Ovarian Res. 2009;2:13.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Shih KK, Chi DS. Maximal cytoreductive effort in epithelial ovarian cancer surgery. J Gynecol Oncol. 2010;21(2):75–80.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Tiersten AD, Moon J, Smith HO, Wilczynski SP, Robinson WR 3rd, Markman M, et al. Chemotherapy resistance as a predictor of progression-free survival in ovarian cancer patients treated with neoadjuvant chemotherapy and surgical cytoreduction followed by intraperitoneal chemotherapy: a Southwest Oncology Group Study. Oncology. 2009;77(6):395–9.

    Article  CAS  PubMed  Google Scholar 

  9. Winter-Roach BA, Kitchener HC, Lawrie TA, et al. Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer. Cochrane Database Syst Rev. 2012;3:CD004706.

    PubMed  PubMed Central  Google Scholar 

  10. Tingulstad S, Hagen B, Skjeldestad FE, Onsrud M, Kiserud T, Halvorsen T, et al. Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre-operative diagnosis of pelvic masses. Br J Obstet Gynaecol. 1996;103(8):826–31.

    Article  CAS  PubMed  Google Scholar 

  11. Eser S, Gulhan I, Ozdemir R, Dicle N, Hanhan M, Baloglu A, et al. Synchronous primary cancers of the female reproductive tract in Turkish women. Asian Pac J Cancer Prev. 2011;12(4):857–9.

    PubMed  Google Scholar 

  12. Freedman LS, Edwards B, Ries L, Young J. Cancer incidence in four member countries (Cyprus, Egypt, Israel, and Jordan) of the Middle East Cancer Consortium (MECC) compared with US SEER. Cancer incidence in four member countries (Cyprus, Egypt, Israel, and Jordan) of the Middle East Cancer Consortium (MECC) compared with US SEER. 2006.

  13. Lim MC, Chun KC, Shin SJ, Lee IH, Lim KT, Cho CH, et al. Clinical presentation of endometrioid epithelial ovarian cancer with concurrent endometriosis: a multicenter retrospective study. Cancer Epidemiol Biomarkers Prev. 2010;19(2):398–404.

    Article  CAS  PubMed  Google Scholar 

  14. Ness RB, Cramer DW, Goodman MT, Kjaer SK, Mallin K, Mosgaard BJ, et al. Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case–control studies. Am J Epidemiol. 2002;155(3):217–24.

    Article  PubMed  Google Scholar 

  15. Horvath LE, Werner T, Boucher K, Jones K. The relationship between tumor size and stage in early versus advanced ovarian cancer. Med Hypotheses. 2013;80(5):684–7.

    Article  PubMed  Google Scholar 

  16. Chan JK, Tian C, Monk BJ, Herzog T, Kapp DS, Bell J, et al. Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer. 2008;112(10):2202–10.

    Article  PubMed  Google Scholar 

  17. Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ, et al. Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol. 2004;94(2):456–62.

    Article  PubMed  Google Scholar 

  18. Williams MG, Bandera EV, Demissie K, Rodriguez-Rodriguez L. Synchronous primary ovarian and endometrial cancers: a population-based assessment of survival. Obstet Gynecol. 2009;113(4):783–9.

    Article  PubMed  Google Scholar 

  19. Elit LM, Bondy SJ, Paszat LP, Holowaty EJ, Thomas GM, Stukel TA, et al. Surgical outcomes in women with ovarian cancer. Can J Surg. 2008;51(5):346–54.

    PubMed  PubMed Central  Google Scholar 

  20. Masuda K, Banno K, Yanokura M, Kobayashi Y, Kisu I, Ueki A, et al. Carcinoma of the lower uterine segment (LUS): clinicopathological characteristics and association with Lynch syndrome. Curr Genomics. 2011;12(1):25–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Martinek IE, Kehoe S. When should surgical cytoreduction in advanced ovarian cancer take place? J Oncol. 2010;2010:852028.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

My sincere thanks to Dr Vinod Pillai and Mrs Vishruti B Pandya for helping with the statistical analysis.

Author information

Authors and Affiliations

  1. Gujarat Cancer and Research Institute, New Civil Hospital Campus, Asarwa, Ahmedabad, 380016, India

    Deepa Rajan, Meeta H. Mankad, Pariseema S. Dave, Anjana S. Chauhan, Ava D. Desai & Kalpana S. Dave

  2. Flat no 2, Chaitali Cooperative Housing Society, Sector 16, Plot no. 31, Vashi, Navi Mumbai, 400703, Maharashtra, India

    Deepa Rajan

Authors
  1. Deepa Rajan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Meeta H. Mankad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pariseema S. Dave
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anjana S. Chauhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ava D. Desai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kalpana S. Dave
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Deepa Rajan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rajan, D., Mankad, M.H., Dave, P.S. et al. Clinicopathological Perspectives on Endometrioid Epithelial Ovarian Carcinoma in Indian Women. Indian J Gynecol Oncolog 13, 2 (2015). https://doi.org/10.1007/s40944-015-0002-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s40944-015-0002-8

Keywords

Search

Navigation