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Exploring the landscape between synthetic and biosynthetic materials discovery: important considerations via systems connectivity, cooperation and scale-driven convergence in biomanufacturing

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Biomanufacturing Reviews

Abstract

Scale driven convergence at the intersection of biology and chemistry could be strategically important in defining a new era in biomanufacturing of materials requiring greater functional complexity. Broadening the functional capability of biologically derived molecules lies in understanding the mechanisms that are intrinsic to their design. While gene modification has been a successful engineering tool to adapt biomanufacturing processes, the bioconvergence of nanochemistry and biology driven by scale is poised to push the boundaries of innovation. The merger of synthetic and biological materials will predictably be an emerging area of importance in the future and in this review we probe the discovery path to biointelligent systems and its potential impact on manufacturing. In the digital age, we also discuss how artificial intelligence will affect the growth trajectory of new materials in the context of a systems driven approach and its relationship with biomimetics.

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Fig. 1
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Reproduced with permission from Khare and Sonkaria [10], Copyright 2019 Elsevier; Sonkaria et al. [20], Scientific Reports

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Adapted from Sonkaria et al., Copyright 2017, Wiley–VCH

Fig. 7

Adapted with permission from Lee et al. [61], Copyright 2018, Elsevier

Fig. 8

Reproduced from Gomes et al. [62] Copyright 2019, MRS Bulletin

Fig. 9

Copyright 2019, Stein and Gregoire [44]—reproduced by permission of The Royal Society of Chemistry

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Website content adapted with permission by Michael Nielsen; http://neuralnetworksanddeeplearning.com/chap5.html

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Copyright 2015, from Simon et al. [45]—reproduced by permission of The Royal Society of Chemistry

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Reproduced with permission from Le and Winkler [47], Copyright 2016

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Reproduced by permission from Park et al. [63] Copyright 2010, Elsevier

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Reproduced from Chun et al. [64]

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Adapted with permission from Patel et al. [59], American Chemical Society, Copyright 2014

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Fig. 18

Reproduced from Choi et al. [20]

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Acknowledgements

This work acknowledges support from National Research Foundation of Korea (NRF was supported by the) funded by Korean government 2017R1A2B4008801, 2012R1A2A2A01047189, and NRF Basic Research Programme in Science and Engineering by the Ministry of Education (No. 2017R1D1A1B03036226) and by the INDO-KOREA JNC program of the National Research Foundation of Korea Grant No. 2017K1A3A1A68.

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  1. Institute of Advanced Machinery and Design, Seoul National University, Daehak-dong, Gwanak-gu, Seoul, 08826, Republic of Korea

    Sanjiv Sonkaria & Varsha Khare

  2. Institute of Advanced Machinery and Design, Seoul National University, Engineering 301-1405, San 56-1, Shilim, Kwanak, Seoul, 151-744, Republic of Korea

    Sanjiv Sonkaria & Varsha Khare

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  1. Sanjiv Sonkaria
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Correspondence to Sanjiv Sonkaria or Varsha Khare.

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Sonkaria, S., Khare, V. Exploring the landscape between synthetic and biosynthetic materials discovery: important considerations via systems connectivity, cooperation and scale-driven convergence in biomanufacturing. Biomanuf Rev 5, 1 (2020). https://doi.org/10.1007/s40898-020-0007-7

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