Abstract
Purpose of review
Heated high-flow nasal cannula (HFNC) is used in management of acute respiratory distress and is increasingly used in the emergency department (ED) and ward setting. This review aimed to highlight existing literature on ward use of HFNC.
Recent findings
HFNC reduces work of breathing, increases mucociliary clearance, and improves oxygenation. Within limits, HFNC can be safely used on pediatric wards for management of moderate to severe respiratory distress. Weight-based and non-weight-based flow rates have been successfully used on pediatric wards, and maximum acceptable flow rates on wards are site and resource specific. Frequent monitoring can identify responders and non-responders requiring escalation. Early observation suggests that oral feeding is safe. Ward HFNC weaning protocols are lacking.
Summary
Evidence suggests that in selected populations of children with moderate to severe respiratory distress due to acute bronchiolitis, HFNC with close monitoring is safe for use on the pediatric wards.
Similar content being viewed by others
References and Recommended Reading
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
Wilkinson DJ, Andersen CC, Smith K, Holberton J. Pharyngeal pressure with high-flow nasal cannulae in premature infants. J Perinatol. 2008;28(1):42–7.
Walsh BK, Smallwood CD. Pediatric oxygen therapy: a review and update. Respir Care. 2017;62(6):645–61.
Ritchie JE, Williams AB, Gerard C, Hockey H. Evaluation of a humidified nasal high-flow oxygen system, using oxygraphy, capnography and measurement of upper airway pressures. Anaesth Intensive Care. 2011;39(6):1103–10.
Mündel T, Feng S, Tatkov S, Schneider H. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol. 2013;114(8):1058–65.
Frizzola M, Miller TL, Rodriguez ME, Zhu Y, Rojas J, Hesek A, et al. High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol. 2011;46(1):67–74.
Arora B, Mahajan P, Zidan MA, Sethuraman U. Nasopharyngeal airway pressures in bronchiolitis patients treated with high-flow nasal cannula oxygen therapy. Pediatr Emerg Care. 2012;28(11):1179–84.
Pham TM, O’Malley L, Mayfield S, Martin S, Schibler A. The effect of high flow nasal cannula on the work of breathing in infants with bronchiolitis. Pediatr Pulmonol. 2014;50:713–20.
Kilgour E, Rankin N, Ryan S, Pack R. Mucociliary function deteriorates in the clinical range of inspired air temperature and humiditiy. Intensive Care Med. 2004;30:1491–4. https://doi.org/10.1007/s00134-004-2235-3.
Sivieri EM, Foglia EE, Abbasi S. Carbon dioxide washout during high flow nasal cannula versus nasal CPAP support: an in vitro study. Pediatr Pulmonol. 2017;52:792–8. https://doi.org/10.1002/ppul.23664.
Gerdes J, Abbasi SE. Non-invasive ventilation in neonates: effect of nasal cannula size, insertion depth and nares diameter on mean airway pressure—an in-vitro study. Arch Dis Child. 2014;99:A248.
Wing R, James C, Maranda LS, Armsby CC. Use of high-flow nasal cannula support in the emergency department reduces the need for intubation in pediatric acute respiratory insufficiency. Pediatr Emerg Care. 2012;28(11):1117–23.
•• Mayfield S, Boggossian F, O’Malley L, Schibler A. High flow nasal cannula oxygen therapy for infants with bronchiolitis: a pilot study. J Paediatr Child Health. 2014;50:373–8. This study showed that HFNC is safe on the pediatric wards. Non-responders requiring PICU can be recognized within 1 h based on heart rate and respiratory rate
Kelly GS, Simon HK, Sturm JJ. High flow nasal cannula use in children with respiratory distress in the emergency department. Pediatr Emerg Care. 2013;29(8):888–92.
Canares TL, Tucker C, Garro A. Going with the flow: respiratory care in the pediatric emergency department. RI Med J. 2014;97(1):23–6.
Abboud PA, Roth PJ, Skiles CL, Stolfi A, Rowin ME. Predictors of failure in infants with viral bronchiolitis treated with high-flow, high-humidity nasal cannula therapy. Pediatr Crit Care Med. 2012;13(6):e343–9.
•• McKiernan C, Chua LC, Visintainer PF, Allen H. High flow nasal cannula therapy in infants with bronchiolitis. J Pediatr. 2010;156(4):634–8. This study demonstrated that HFNC reduced intubation rate in the PICU by reducing respiratory rate and work of breathing and by providing a comfortable and well-tolerated means of providing non-invasive ventilation
Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, et al. A randomized trial of high flow therapy in infants with bronchiolitis. N Engl J Med. 2018;378:1121–31.
Coletti KD, Bagdure DN, Walker LK, Remy KE, Custer JW. High-flow nasal cannula utilization in pediatric critical care. Respir Care. 2017;62(8):1023–9.
Manley BJ, et al. High-flow nasal cannula in very preterm infants after extubation. N Engl J Med. 2013;369.15:1425–33. Yoder
Collins CL, Holberton JR, Barfield C, Davis PG. A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants. J Pediatr. 2013;162(5):949–54.
Spentzas T, Minarik M, Patters AB, Vinson B, Stidham G. Children with respiratory distress treated with high-flow nasal cannula. J Intensive Care Med. 2009;24(5):323–8.
Hall GL, Hantos Z, Wildhaber JH, Sly PD. Contribution of nasal pathways to low frequency respiratory impedance in infants. Thorax. 2002;57(5):396–9.
Riese J, et al. Clinical outcomes of bronchiolitis after implementation of a general ward high flow nasal cannula guideline. Hosp Pediatr. 2017;7.4:197–203.
Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):e1474–502.
Collins C, Chan T, Roberts JS, et al. High-flow nasal cannula in bronchiolitis: modeling the economic effects of a ward-based protocol. Hosp Pediatr. 2017 2016–0167.
Beggs S, Wong ZH, Kaul S, Ogden KJ, Walters JAE. High-flow nasal cannula therapy for infants with bronchiolitis. Cochrane Database Syst Rev. 2014;(Issue 1):CD009609. https://doi.org/10.1002/14651858.CD009609.pub2.
Reise J, et al. Effect of a hospital-wide high flow nasal cannula protocol on clinical outcomes and resource utilizations of bronchiolitis patients admitted to the PICU. Hosp Pediatr. 2015;5.12:613–8.
Weiler T, Kamerkar A, Hotz J, Ross P, Newth C, Khemani R. The relationship between high flow nasal cannula flow rate and effort of breathing in children. J Pediatr. 2017;189:66–71.e3.
Keprotes E, Whitehead B, Attia J, et al. High-flow warm humidified oxygen versus standard low-flow nasal cannula for moderate bronchiolitis: an open, phase 4, randomized controlled trial. Lancet. 2017;389:930–9.
Bressen S, Balzani M, Krauss B, Pettenazo A, Zanconato S, Baraldi E. High flow nasal cannula oxygen for bronchiolitis in pediatric ward: a pilot study. Eur J Pediatr. 2013;172:1649–56.
Brink F, Duke T, Evans J. High flow prong oxygen therapy or nasopharyngeal continuous positive airway pressure for children with moderate to severe respiratory distress? Pediatr Crit Care Med. 2013;7(14):e326–31.
Kallapa C, Hufton M, Millen G, Ninan TK. Use of high flow nasal cannula oxygen (HFNCO) in infants with bronchiolitis: a 3 year experience. Arch Dis Child. 2014 Aug;99(8):790–1.
Goh T, Kirby LJ, Schell DN, Egan JR. Humidified high flow nasal cannula oxygen in bronchiolitis reduces need for invasive ventilation but not intensive care admission. J Pediatr Child Health. 2017;53(9):897–902.
Betters KA, Gellespie SE, Miller J, Kotzbauer D, Hebbar KB. High flows nasal cannula use outside the ICU: factors associated with failure. Pediatr Pulmonol. 2017 Jun.;52(6):806–12.
Betters KA, Hebbar KB, McCracken C, Heitz D, Sparacino S, Petrillo T. A novel weaning protocol of high flow nasal cannula in the PICU. Pediatr Crit Care Med. 2017;18(7):e274–80.
•• Milesi C, et al. High flow nasal cannula: recommendations for daily practice in pediatrics. Ann Intensive Care. 2014;4:29. This is a review article that emphasizes that like any new device, use of HFNC requires close monitoring
Samson N, Nadeau C, Vincent L, Cantin D, Praud JP. Effects of nasal continuous positive airway pressure and high flow nasal cannula on sucking, swallowing, and breathing during bottle-feeding in lambs. Front Pediatr. 2018;5:296.
Slain KN, Martinez-Schlumann N, Shein SL, Stormorken A. Nutrition and high-flow nasal cannula respiratory support in children with bronchiolitis. Hosp Pediatr. 2017;7(5):256–62.
Franklin D, et al. Early high flow nasal cannula therapy in bronchiolitis, a prospective randomized control trial (protocol): a Pediatric Acute Respiratory Intervention Study (PARIS). BMC Pediatr. 2015;15:183.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Sonal Kalburgi declares that she has no conflicts of interest. Tina Halley declares that she has no conflicts of interest. Irini N. Kolaitis declares that she has no conflicts of interest. Kristen Hood declares that she has no conflicts of interest. Vineeta Mittal declares that she has no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Hospital Medicine
Rights and permissions
About this article
Cite this article
Kalburgi, S., Halley, T., Kolaitis, I.N. et al. A Review of Heated High-Flow Nasal Cannula in Pediatrics—From Critical Care to Ward Use. Curr Treat Options Peds 4, 319–329 (2018). https://doi.org/10.1007/s40746-018-0128-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40746-018-0128-x