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Characterization of a cohort of storage mite sensitized subjects

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Abstract

Purpose

Storage mites (SM) are ubiquitously found close to human habitation and are a source of allergic reactions ranging from allergic rhinitis and asthma to anaphylactic reactions.

Methods

Data on 3997 patients with suspected allergic rhinitis were included. We performed correlation of intradermal testing and specific IgE-test results using Cohen’s kappa and univariate logistic regression to evaluate the probability of symptoms and the point of time symptoms were reported. In some patients nasal provocation was performed to prove allergic rhinitis.

Results

Patients with storage mite sensitization show a high degree of cross reactivity between different storage mite species. Cross reactivity of storage mite species with house dust mites (HDM) was found in 56% and is only slightly higher than that of other common allergens such as grasses (45%) or birch (42%). A correlation of intradermal testing and specific IgE testing could not be found. The most common symptoms of sensitized subjects were nasal obstruction and hyposmia and symptoms were dependent on presence of chronic sinusitis. Nasal provocation was positive in 16 to 33% of subjects tested.

Conclusions

SM are a common sensitization in the study population and should be included in standard skin prick test arrays. Cross sensitization to house dust mites is limited and nasal symptoms are most frequent. Nasal provocation testing is necessary to secure clinical diagnosis of allergy and further research is needed to evaluate the clinical relevance of the high sensitization rates found for intradermal testing.

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References

  1. Arlian LG, Morgan MS, Vyszenski-Moher DL, Sharra D. Cross-reactivity between storage and dust mites and between mites and shrimp. Exp Appl Acarol. 2009;47:159–72.

    Article  Google Scholar 

  2. Cotter M, Siebers R, Pike A, Fitzharris P, Crane J. Storage mites in flour samples in Wellington, New Zealand. J Investig Allergol Clin Immunol. 2011;21:410–1.

    CAS  PubMed  Google Scholar 

  3. Hage-Hamsten M van, Johansson E. Clinical and immunologic aspects of storage mite allergy. Allergy 1998;53(48 Suppl):49–53

    Article  Google Scholar 

  4. Son M, Jeong KY, Kim BJ, Lim KJ, Lee JH, Park JW. IgE reactivity to Acarus siro extract in Korean dust mite allergic patients. Exp Appl Acarol. 2014;63:57–64.

    Article  CAS  Google Scholar 

  5. van Hage-Hamsten M, Machado L, Barros MT, Johansson SG. Comparison of clinical significance and allergenic cross-reactivity of storage mites Blomia kulagini and Lepidoglyphus destructor in Sweden and Brazil. Allergy. 1990;45(6):409–17. https://doi.org/10.1111/j.1398-9995.1990.tb01091.x.

    Article  PubMed  Google Scholar 

  6. Sanchez-Borges M, Fernandez-Caldas E. Hidden allergens and oral mite anaphylaxis: the pancake syndrome revisited. Curr Opin Allergy Clin Immunol. 2015;15:337–43.

    Article  CAS  Google Scholar 

  7. Ebner C, Feldner H, Ebner H, Kraft D. Sensitization to storage mites in house dust mite (Dermatophagoides pteronyssinus) allergic patients. Comparison of a rural and an urban population. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. IEEE Trans Med Imaging. 1994;24:347:52.

    Google Scholar 

  8. Jakubas-Zawalska J, Asman M, Solarz K. Sensitization to the storage mites Lepidoglyphus destructor and Tyrophagus putrescentiae (Acari, Sarcoptiformes, Astigmatina) in a suburban population in Southern Poland. Ann Parasitol. 2017;63:183–8.

    PubMed  Google Scholar 

  9. van der Heide S, Niemeijer NR, Hovenga H, de Monchy JG, Dubois AE, Kauffman HF. Prevalence of sensitization to the storage mites Acarus siro, Tyrophagus putrescentiae, and Lepidoglyphus destructor in allergic patients with different degrees of sensitization to the house-dust mite Dermatophagoides pteronyssinus. Allergy. 1998;53:426–30.

    Article  Google Scholar 

  10. Revsbech P, Andersen G. Storage mite allergy among grain elevator workers. Allergy. 1987;42:423–9.

    Article  CAS  Google Scholar 

  11. Spiewak R, Gora A, Dutkiewicz J. Work-related skin symptoms and type I allergy among eastern-Polish farmers growing hops and other crops. Ann Agric Environ Med. 2001;8:51–6.

    CAS  PubMed  Google Scholar 

  12. Armentia A, Martinez A, Castrodeza R, Martinez J, Jimeno A, Mendez J, et al. Occupational allergic disease in cereal workers by stored grain pests. J Asthma. 1997;34:369–78.

    Article  CAS  Google Scholar 

  13. Akdemir C, Gurdal H. House dust mite in Kutahya, Turkey.]. Turkiye parazitolojii dergisi. IEEE Trans Med Imaging. 2005;29:110:5.

    Google Scholar 

  14. Marx JJ Jr., Twiggs JT, Ault BJ, Merchant JA, Fernandez-Caldas E. Inhaled aeroallergen and storage mite reactivity in a Wisconsin farmer nested case-control study. Am Rev Respir Dis. 1993;147:354–8.

    Article  Google Scholar 

  15. Johansson E, Johansson SG, Van Hage-Hamsten M. Allergenic characterization of Acarus siro and Tyrophagus putrescentiae and their crossreactivity with Lepidoglyphus destructor and Dermatophagoides pteronyssinus. Clin Exp Allergy. 1994;24:743–51.

    Article  CAS  Google Scholar 

  16. Morales M, Iraola V, Leonor JR, Bartra J, Rodriguez F, Boquete M, et al. Different sensitization to storage mites depending on the co-exposure to house dust mites. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 2015;114:36–42 e1

    Article  CAS  Google Scholar 

  17. Musken H, Fernandez-Caldas E, Maranon F, Franz JT, Masuch G, Bergmann KC. In vivo and in vitro sensitization to domestic mites in German urban and rural allergic patients. J Investig Allergol Clin Immunol. 2002;12:177–81.

    PubMed  Google Scholar 

  18. Palacios Pelaez R, Martinez-Garate A, Perez OA. Study of the possible crossed reactivity between D. pteronyssinus and non pyroglyphide acarus. 1. Skin tests and FAST inhibition. Allergologia et immunopathologia. Perez. 1992;20:161–4.

    CAS  Google Scholar 

  19. Airaksinen L, Tuomi T, Vanhanen M, Voutilainen R, Toskala E. Use of nasal provocation test in the diagnostics of occupational rhinitis. Rhinology. 2007;45:40–6.

    PubMed  Google Scholar 

  20. Sanchez-Machin I, Gonzalez PPR, Iglesias-Souto J, Iraola V, Matheu V. Asthma and rhinitis by storage mites. Allergy. 2011;66:1615–6.

    Article  CAS  Google Scholar 

  21. King MJ, Tamulis T, Lockey RF. Prick puncture skin tests and serum specific IgE as predictors of nasal challenge response to dermatophagoides pteronyssinus in older adults. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 2008;101:12–7

    Article  Google Scholar 

  22. Haxel BR, Huppertz T, Boessert P, Bast F, Fruth K. Correlation of skin test results and specific immunoglobulin E blood levels with nasal provocation testing for house-dust mite allergies. Am J Rhinol Allergy. 2016;30:60–4.

    Article  Google Scholar 

  23. Haxel BR. Relevance of nasal provocation testing in house dust mite allergy. HNO. 2017;65:811–7.

    Article  CAS  Google Scholar 

  24. Kirerleri E, Guler N, Tamay Z, Ones U. Evaluation of the nasal provocation test for its necessity in the diagnosis of nasal allergy to house dust mite. Asian Pac J Allergy Immunol. 2006;24:117–21.

    CAS  PubMed  Google Scholar 

  25. Johansson E, Borga A, Johansson SG, Van Hage-Hamsten M. Immunoblot multi-allergen inhibition studies of allergenic cross-reactivity of the dust mites Lepidoglyphus destructor and Dermatophagoides pteronyssinus. Clin Exp Allergy. 1991;21:511–8.

    Article  CAS  Google Scholar 

  26. Ventas P, Carreira J, Polo F. Purification and characterization of Lep d I, a major allergen from the mite Lepidoglyphus destructor. Clin Exp Allergy. 1992;22:454–60.

    Article  CAS  Google Scholar 

  27. Eriksson TL, Johansson E, Whitley P, Schmidt M, Elsayed S, van Hage-Hamsten M. Cloning and characterisation of a group II allergen from the dust mite Tyrophagus putrescentiae. Eur J Biochem. 1998;251:443–7.

    Article  CAS  Google Scholar 

  28. Eriksson TL, Whitley P, Johansson E, van Hage-Hamsten M, Gafvelin G. Identification and characterisation of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins. Int Arch Allergy Immunol. 1999;119:275–81.

    Article  CAS  Google Scholar 

  29. Schultze-Werninghaus G. A new questionaire in the diagnosis of allergic lung disease suitable for evaluation by computer (author’s transl). Prax Klin Pneumol. 1977;31:642–52.

    CAS  PubMed  Google Scholar 

  30. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.

    Article  CAS  Google Scholar 

  31. Akdemir C, Soyucen E. Sensitization of children to storage mites in Kutahya. Turkey Korean J Parasitol. 2009;47:387–91.

    Article  Google Scholar 

  32. Griffin P, Ford AW, Alterman L, Thompson J, Parkinson C, Blainey AD, et al. Allergenic and antigenic relationship between three species of storage mite and the house dust mite, Dermatophagoides pteronyssinus. J Allergy Clin Immunol. 1989;84:108–17.

    Article  CAS  Google Scholar 

  33. Arias-Irigoyen J, Lombardero M, Arteaga C, Carpizo JA, Barber D. Limited IgE cross-reactivity between Dermatophagoides pteronyssinus and Glycyphagus domesticus in patients naturally exposed to both mite species. J Allergy Clin Immunol. 2007;120:98–104.

    Article  CAS  Google Scholar 

  34. Zhang C, Li J, Lai X, Zheng Y, Gjesing B, Spangfort MD, et al. House dust mite and storage mite IgE reactivity in allergic patients from Guangzhou, China. Asian Pac J Allergy Immunol. 2012;30:294–300.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center, Johannes Gutenberg University, Langenbeckstraße 1, 55131, Mainz, Germany

    Tilman Huppertz MD, S. Becker & Boris R. Haxel

  2. Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany

    Irene Schmidtmann

  3. Department of Otorhinolaryngology, Head and Neck Surgery, AMEOS Klinikum Haldensleben, Haldensleben, Germany

    Boris R. Haxel

Authors
  1. Tilman Huppertz MD
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  2. Irene Schmidtmann
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Correspondence to Tilman Huppertz MD.

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Conflict of interest

T. Huppertz, I. Schmidtmann, S. Becker and B.R. Haxel declare that they have no competing interests.

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Huppertz, T., Schmidtmann, I., Becker, S. et al. Characterization of a cohort of storage mite sensitized subjects. Allergo J Int 29, 1–8 (2020). https://doi.org/10.1007/s40629-019-00108-3

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