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Autoallergy in atopic dermatitis

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Abstract

The term autoallergy denotes autoimmunity accompanying an atopic disease, with antigen-specific IgE as a hallmark. This phenomenon is discussed to contribute to a chronification of the disease and to shape the immune response in chronic atopic dermatitis (AD). In this review, we highlight recent insights into the autoallergic inflammation in AD. Different mechanisms underlying the allergenicity of autoallergens are discussed at the moment: intrinsic functions modulating the immune system as well as molecular mimicry may influence the allergenic potential of these proteins. Finally, the role of specific T cells is discussed.

Cite this as: Hradetzky S, Werfel T, Roesner LM. Autoallergy in atopic dermatitis. Allergo J Int 2015; 24:16–22 DOI: 10.1007/s40629-015-0037-5

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Abbreviations

AD:

Atopic dermatitis

cDNA:

Complementary deoxyribonucleic acid

CIA:

Collegium Internationale Allergologicum

DAMP:

Danger-associated molecular pattern

Fc:

Fragment crystallizable

hTrx:

Human thioredoxin

IFN:

Interferon

IgE:

Immunglobulin E

IL:

Interleukin

ILC:

Innate lymphoid cell

IUIS:

International Union of Immunological Societies

ML:

MD-2-related lipid recognition

MnSOD:

Manganese superoxide dismutase

NAC:

Nascent protein associated complex

PAMP:

Pathogen-associated molecular patterns

PAR:

Protease-activated receptors

PBMC:

Peripheral blood mononuclear cells

TEMRA:

CD45RA re-expressing effector/memory T cell

Th:

T helper cell

TLR:

Toll-like receptor

Trx:

Thioredoxin

TSLP:

Thymic stromal lymphopoietin

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Authors and Affiliations

  1. Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany

    Susanne Hradetzky, Thomas Werfel &  Lennart M. Rösner

  2. Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany

    Lennart M. Rösner

Authors
  1. Susanne Hradetzky
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  2. Thomas Werfel
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  3. Lennart M. Rösner
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Correspondence to Lennart M. Rösner.

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Hradetzky, S., Werfel, T. & Rösner, L.M. Autoallergy in atopic dermatitis. Allergo J Int 24, 16–22 (2015). https://doi.org/10.1007/s40629-015-0037-5

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