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The effect of protein-enriched snacks on serum albumin concentration in non-selected haemodialysis patients

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Journal of Nephrology Aims and scope Submit manuscript

Abstract

Objective

Serum albumin level is not only one of the protein-energy wasting criteria but also a powerful marker of mortality in patients on haemodialysis (HD) treatment. The study aimed to assess the effect of a protein-enriched snack given during HD treatment on serum albumin level.

Design and methods

This prospective, single-centre, observational, non-randomized 16-month study was sub-divided into four 4-month periods. Patients on hemodialysis for more than three months and receiving a regular standard snack (8.8 g of protein) during the HD session were included and assigned during four four-month periods to receive either the standard snack or a protein-enriched snack (28.7 g). Patients were not selected based on nutritional criteria.

Results

Sixty-six patients completed the study. Serum albumin levels significantly increased, from 3.43 ± 0.28 g/dl in the first period (standard snack) to 3.62 ± 0.32 g/dl (p < 0.0001) in the second period (enriched snack). In the third period (standard snack), albumin levels remained stable (3.61 ± 0.35 g/dl). After the fourth period (enriched snack), serum albumin levels further increased significantly (3.69 ± 0.30 g/dl; p = 0.05 and p = 0.007, respectively). Weight and normalized protein nitrogen appearance remained stable during the 16-month study period.

Conclusions

This study suggests that the intake of a protein-enriched snack during HD treatment, independently from baseline serum albumin level, could significantly increase their serum albumin levels. Serum albumin level is a powerful predictor of mortality; therefore, this simple and effective action could be of real interest to improve patients’ outcomes.

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Acknowledgements

To Cecile Bonhomme and Lactalis group for their conceptual and material contribution to this study.

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Authors and Affiliations

  1. Nephrology and Dialysis Centre, Nephrocare Tassin Charcot, 7 Avenue Marechal Foch, 69110, Sainte-Foy-Les-Lyon, France

    Patrik Deleaval, Jean Guillaume, Anne-Lise Bernollin, Christie Lorriaux, Jean-Marc Hurot, Brice Major, Manolie Mehdi & Charles Chazot

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  1. Patrik Deleaval
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  2. Jean Guillaume
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  3. Anne-Lise Bernollin
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  4. Christie Lorriaux
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  7. Manolie Mehdi
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  8. Charles Chazot
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Contributions

DP: Conception and design; data analysis and interpretation; provision of study patients; manuscript writing; final approval of manuscript. JG: Conception and design; data analysis and interpretation; provision of study patients; manuscript writing; final approval of manuscript. BA-L: Conception and design; data analysis and interpretation; final approval of manuscript. LC: Conception and design; provision of study patients; final approval of manuscript. HJ-M: Conception and design; provision of study patients; final approval of manuscript. MB: Conception and design; provision of study patients; final approval of manuscript. MM: Conception and design; provision of study patients; final approval of manuscript. CC: Conception and design; data analysis and interpretation; provision of study patients; manuscript writing; final approval of manuscript. All authors read and approved the final manuscript.

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Correspondence to Patrik Deleaval.

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Deleaval, P., Guillaume, J., Bernollin, AL. et al. The effect of protein-enriched snacks on serum albumin concentration in non-selected haemodialysis patients. J Nephrol 34, 1291–1299 (2021). https://doi.org/10.1007/s40620-020-00887-x

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  • DOI: https://doi.org/10.1007/s40620-020-00887-x

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