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Kidney transplantation in ANCA-associated vasculitis

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Abstract

The kidney is commonly affected in patients with ANCA-associated vasculitis (AAV), causing end-stage renal disease (ESRD) in 20–40% of cases. Kidney transplantation is the treatment of choice for eligible patients with ESRD due to AAV. This review provides a summary of patient and graft outcome after kidney transplantation in AAV patients, the risk of relapse and the optimal time of transplantation. We also address the rare event of de novo ANCA-associated vasculitis after kidney transplantation and the treatment options.

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Abbreviations

AAV:

Anti-neutrophil cytoplasmic antibody-associated vasculitis

ANCA:

Anti-neutrophil cytoplasmic antibody

EGPA:

Eosinophilic granulomatosis with polyangiitis

ESRD:

End-stage renal disease

GPA:

Granulomatosis with polyangiitis

MPA:

Microscopic polyangiitis

MPO:

Myeloperoxidase

PR3:

Proteinase 3

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Authors and Affiliations

  1. Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

    Michael S. Sagmeister

  2. Nephrology Division, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München - Campus Großhadern, Munich, Germany

    Melissa Grigorescu & Ulf Schönermarck

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  1. Michael S. Sagmeister
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Sagmeister, M.S., Grigorescu, M. & Schönermarck, U. Kidney transplantation in ANCA-associated vasculitis. J Nephrol 32, 919–926 (2019). https://doi.org/10.1007/s40620-019-00642-x

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