Abstract
This article aims to provide an overview of the different nutritional markers and the available methodologies for the physical assessment of nutrition status in hemodialysis patients, with special emphasis on early detection of protein energy wasting (PEW). Nutrition status assessment is made on the basis of anamnesis, physical examination, evaluation of nutrient intake, and on a selection of various screening/diagnostic methodologies. These methodologies can be subjective, e.g. the Subjective Global Assessment score (SGA), or objective in nature (e.g. bioimpedance analysis). In addition, certain biochemical tests may be employed (e.g. albumin, pre-albumin). The various subjective-based and objective methodologies provide different insights for the assessment of PEW, particularly regarding their propensity to differentiate between the important body composition compartments—fluid overload, fat mass and muscle mass. This review of currently available methods showed that no single approach and no single marker is able to detect alterations in nutrition status in a timely fashion and to follow such changes over time. The most clinically relevant approach presently appears to be the combination of the SGA method with the bioimpedance spectroscopy technique with physiological model and, additionally, laboratory tests for the detection of micro-nutrient deficiency.
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References
Ikizler TA (2008) Nutrition, inflammation and chronic kidney disease. Curr Opin Nephrol Hypertens 17:162–167
Pupim LB, Caglar K, Hakim RM, Shyr Y, Ikizler TA (2004) Uremic malnutrition is a predictor of death independent of inflammatory status. Kidney Int 66:2054–2060
Mak RH, Cheung W (2006) Energy homeostasis and cachexia in chronic kidney disease. Pediatr Nephrol 21:1807–1814
Lindholm B, Heimburger O, Stenvinkel P (2002) What are the causes of protein-energy malnutrition in chronic renal insufficiency? Am J Kidney Dis 39:422–425
Pecoits-Filho R, Lindholm B, Stenvinkel P (2002) The malnutrition, inflammation, and atherosclerosis (MIA) syndrome—the heart of the matter. Nephrol Dial Transplant 17(Suppl 11):28–31
Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD (2003) Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis 42:864–881
Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Trevino-Becerra A, Wanner C (2008) A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73:391–398
Kimmel PL, Phillips TM, Simmens SJ, Peterson RA, Weihs KL, Alleyne S, Cruz I, Yanovski JA, Veis JH (1998) Immunologic function and survival in hemodialysis patients. Kidney Int 54:236–244
Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C (1999) Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 55:648–658
Borrego Utiel FJ, Segura TP, Perez del Barrio MP, Sanchez Perales MC, Garcia Cortes MJ, Serrano AP, Biechy Baldan MM, Liebana CA (2011) How do disorders related to hospitalisation influence haemodialysis patients’ nutrition? Nefrologia 31:471–483
Ikizler TA, Wingard RL, Harvell J, Shyr Y, Hakim RM (1999) Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int 55:1945–1951
Fouque D, Vennegoor M, Ter WP, Wanner C, Basci A, Canaud B, Haage P, Konner K, Kooman J, Martin-Malo A, Pedrini L, Pizzarelli F, Tattersall J, Tordoir J, Vanholder R (2007) EBPG guideline on nutrition. Nephrol Dial Transplant 22(Suppl 2):ii45–ii87
Canaud B, Granger VA, Molinari N, Chenine L, Leray-Moragues H, Rodriguez A, Chalabi L, Morena M, Cristol JP (2014) Creatinine index as a surrogate of lean body mass derived from urea Kt/V, pre-dialysis serum levels and anthropometric characteristics of haemodialysis patients. PLoS One 9:e93286
Donadio C, Halim AB, Caprio F, Grassi G, Khedr B, Mazzantini M (2008) Single- and multi-frequency bioelectrical impedance analyses to analyse body composition in maintenance haemodialysis patients: comparison with dual-energy X-ray absorptiometry. Physiol Meas 29:S517–S524
Wieskotten S, Heinke S, Wabel P, Moissl U, Becker J, Pirlich M, Keymling M, Isermann R (2008) Bioimpedance-based identification of malnutrition using fuzzy logic. Physiol Meas 29:639–654
Cohn SH, Vaswani AN, Yasumura S, Yuen K, Ellis KJ (1985) Assessment of cellular mass and lean body mass by noninvasive nuclear techniques. J Lab Clin Med 105:305–311
Gomez-Besteiro MI, Santiago-Perez MI, Alonso-Hernandez A, Valdes-Canedo F, Rebollo-Alvarez P (2004) Validity and reliability of the SF-36 questionnaire in patients on the waiting list for a kidney transplant and transplant patients. Am J Nephrol 24:346–351
Pupim LB, Kent P, Caglar K, Shyr Y, Hakim RM, Ikizler TA (2002) Improvement in nutritional parameters after initiation of chronic hemodialysis. Am J Kidney Dis 40:143–151
Johansen KL, Kaysen GA, Young BS, Hung AM, Da SM, Chertow GM (2003) Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients. Am J Clin Nutr 77:842–846
Raffaitin C, Lasseur C, Chauveau P, Barthe N, Gin H, Combe C, Rigalleau V (2007) Nutritional status in patients with diabetes and chronic kidney disease: a prospective study. Am J Clin Nutr 85:96–101
Chamney PW, Wabel P, Moissl UM, Muller MJ, Bosy-Westphal A, Korth O, Fuller NJ (2007) A whole-body model to distinguish excess fluid from the hydration of major body tissues. Am J Clin Nutr 85:80–89
Barbosa-Silva MC (2008) Subjective and objective nutritional assessment methods: what do they really assess? Curr Opin Clin Nutr Metab Care 11:248–254
Meireles MS, Wazlawik E, Bastos JL, Garcia MF (2012) Comparison between nutritional risk tools and parameters derived from bioelectrical impedance analysis with subjective global assessment. J Acad Nutr Diet 112:1543–1549
Green SM, Watson R (2006) Nutritional screening and assessment tools for older adults: literature review. J Adv Nurs 54:477–490
Mathew S, Abraham G, Vijayan M, Thandavan T, Mathew M, Veerappan I, Revathy L, Alex ME (2015) Body composition monitoring and nutrition in maintenance hemodialysis and CAPD patients-a multicenter longitudinal study. Ren Fail 37:66–72
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M (2010) Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423
Vagianos K, Bector S, McConnell J, Bernstein CN (2007) Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enteral Nutr 31:311–319
Pham NV, Cox-Reijven PL, Wodzig WK, Greve JW, Soeters PB (2007) SGA and measures for muscle mass and strength in surgical Vietnamese patients. Nutrition 23:283–291
Nascimento MM, Qureshi AR, Stenvinkel P, Pecoits-Filho R, Heimburger O, Cederholm T, Lindholm B, Barany P (2004) Malnutrition and inflammation are associated with impaired pulmonary function in patients with chronic kidney disease. Nephrol Dial Transplant 19:1823–1828
Leal VO, Mafra D, Fouque D, Anjos LA (2011) Use of handgrip strength in the assessment of the muscle function of chronic kidney disease patients on dialysis: a systematic review. Nephrol Dial Transplant 26:1354–1360
Schlussel MM, Anjos LA, Kac G (2008) Hand grip strenght test and its use in nutrtitional assessment. Rev Nutr 21:233–235
Stenver DI, Gotfredsen A, Hilsted J, Nielsen B (1995) Body composition in hemodialysis patients measured by dual-energy X-ray absorptiometry. Am J Nephrol 15:105–110
Ishimura E, Okuno S, Kim M, Yamamoto T, Izumotani T, Otoshi T, Shoji T, Inaba M, Nishizawa Y (2001) Increasing body fat mass in the first year of hemodialysis. J Am Soc Nephrol 12:1921–1926
Fuller NJ, Jebb SA, Laskey MA, Coward WA, Elia M (1992) Four-component model for the assessment of body composition in humans: comparison with alternative methods, and evaluation of the density and hydration of fat-free mass. Clin Sci (Lond) 82:687–693
Maggiore Q, Nigrelli S, Ciccarelli C, Grimaldi C, Rossi GA, Michelassi C (1996) Nutritional and prognostic correlates of bioimpedance indexes in hemodialysis patients. Kidney Int 50:2103–2108
Guida B, De NL, Pecoraro P, Trio R, Di PF, Iodice C, Bellizzi V, Memoli B (2001) Abnormalities of bioimpedance measures in overweight and obese hemodialyzed patients. Int J Obes Relat Metab Disord 25:265–272
Guida B, Trio R, Nastasi A, Laccetti R, Pesola D, Torraca S, Memoli B, Cianciaruso B (2004) Body composition and cardiovascular risk factors in pretransplant hemodialysis patients. Clin Nutr 23:363–372
Presta E, Segal KR, Gutin B, Harrison GG, Van Itallie TB (1983) Comparison in man of total body electrical conductivity and lean body mass derived from body density: validation of a new body composition method. Metabolism 32:524–527
Wabel P, Chamney P, Moissl U, Jirka T (2009) Importance of whole-body bioimpedance spectroscopy for the management of fluid balance. Blood Purif 27:75–80
Garagarza C, Joao-Matias P, Sousa-Guerreiro C, Amaral T, Aires I, Ferreira C, Jorge C, Gil C, Ferreira A (2013) Nutritional status and overhydration: can bioimpedance spectroscopy be useful in haemodialysis patients? Nefrologia 33:667–674
Rosenberger J, Kissova V, Majernikova M, Straussova Z, Boldizsar J (2014) Body composition monitor assessing malnutrition in the hemodialysis population independently predicts mortality. J Ren Nutr 24:172–176
Broers NJ, Usvyat LA, Marcelli D, Bayh I, Scatizzi L, Canaud B, van der Sande FM, Kotanko P, Moissl U, Kooman JP (2014) Season affects body composition and estimation of fluid overload in haemodialysis patients: variations in body composition; a survey from the European MONDO database. Nephrol Dial Transplant. doi:10.1093/ndt/gfu367 (published online December 9, 2014)
Marcelli D, Di BA, Ciotola A, Grassmann A, Canaud B (2014) Subjective global assessment scores have poor correlation with serum albumin in obese hemodialysis patients by Eric D. Erb, Rosa K. Hand, and Alison L. Steiber. J Ren Nutr 24:432–433
Friedman AN, Fadem SZ (2010) Reassessment of albumin as a nutritional marker in kidney disease. J Am Soc Nephrol 21:223–230
Fuhrman MP (2002) The albumin-nutrition connection: separating myth from fact. Nutrition 18:199–200
Spiekerman AM (1995) Nutritional assessment (protein nutriture). Anal Chem 67:429R–436R
Hellberg M, Wiberg EM, Simonsen O, Hoglund P, Clyne N (2014) Small distal muscles and balance predict survival in end-stage renal disease. Nephron Clin Pract 126:116–123
Segal KR, Gutin B, Presta E, Wang J (1985) Van Itallie TB (1985) Estimation of human body composition by electrical impedance methods: a comparative study. J Appl Physiol 58:1565–1571
Lukaski HC (1990) Applications of bioelectrical impedance analysis: a critical review. Basic Life Sci 55:365–374
Piccoli A, Rossi B, Pillon L, Bucciante G (1994) A new method for monitoring body fluid variation by bioimpedance analysis: the RXc graph. Kidney Int 46:534–539
Cole K, Cole RH (1941) Dispersion and absorption in dielectrics. I. Alternating current characteristics. J Chem Phys 9:341–351
Hanai T (1960) Theory of the dielectric dispersion due to the interfacial polarization and its application to emulsions. Kolloid-Zeitschrift 171:23–31
Carter M, Morris AT, Zhu F, Zaluska W, Levin NW (2005) Effect of body mass index (BMI) on estimation of extracellular volume (ECV) in hemodialysis (HD) patients using segmental and whole body bioimpedance analysis. Physiol Meas 26:S93–S99
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All authors are employees of Fresenius Medical Care and may hold stock in the company.
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Marcelli, D., Wabel, P., Wieskotten, S. et al. Physical methods for evaluating the nutrition status of hemodialysis patients. J Nephrol 28, 523–530 (2015). https://doi.org/10.1007/s40620-015-0189-x
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DOI: https://doi.org/10.1007/s40620-015-0189-x