Abstract
Background
Poor adherence to prescribed antihypertensive medication is a major contributor to disparities in effective blood pressure control among Hispanics. The purpose of this study was to investigate the association between health literacy level and adherence to antihypertensive medications among Hispanic adults, who self-reported hypertension, controlling for potential covariates of adherence and/or health literacy.
Methods
We conducted a cross-sectional survey of 1355 Hispanic adults, primarily Dominicans, who self-reported hypertension. Antihypertensive medication adherence and health literacy were evaluated along with covariates, including sociodemographic characteristics, depression, anxiety, and sleep disturbance. Linear regression models were created for health literacy, each covariate, and adherence. Factors found to be significantly associated with adherence in the individual regression models at a p value of < 0.20 were included in a hierarchical multiple linear regression model.
Results
Overall, the majority of participants had low adherence levels to antihypertensive medications (88.4%; n = 1026) and inadequate health literacy (84.9%; n = 1151). When controlling for age, sex, birth country, education level, recruitment location, depression, anxiety, and sleep disturbance, having adequate as compared to inadequate health literacy was associated with a higher adherence score (b = 0.378, p = 0.043). The full model explained 13.6% of the variance in medication adherence (p value < 0.001), but the unique contribution of health literacy to the model was minimal (R2 change = 0.003).
Conclusions
Tailored interventions considering health literacy are needed to support medication adherence in order to improve hypertension outcomes of Hispanics. Additional studies are needed to identify and prioritize factors in the development of targeted and effective adherence interventions for Hispanics with hypertension.
Similar content being viewed by others
Change history
29 April 2019
Please note the following correction in the second paragraph of the Results section of this article, in the sentences that read, “Table 2 shows the association of health literacy level, as well as each of the included covariates with adherence.
References
Merai R. CDC grand rounds: a public health approach to detect and control hypertension. MMWR Morb Mortal Wkly Rep. 2016;65:1261–4.
United States Census Bureau. QuickFacts: UNITED STATES [Internet]. 2017 [cited 2018 Jun 1]. Available from: https://www.census.gov/quickfacts/fact/table/US/PST045217. Accessed 14 May 2018.
Colby SL, Ortman JM. Projections of the size and composition of the U.S: 2014–2060 [Internet]. 2015; p. 1–13. Available from: https://census.gov/content/dam/Census/library/publications/2015/demo/p25-1143.pdf. Accessed 14 May 2018
Centers for Disease Control and Prevention, Office of Minority Health and Health Equity. Hispanic Health [Internet]. 2015. Available from: http://www.cdc.gov/vitalsigns/hispanic-health/index.html. Accessed 14 May 2018
Sorlie PD, Allison MA, Avilés-Santa ML, Cai J, Daviglus ML, Howard AG, et al. Prevalence of hypertension, awareness, treatment, and control in the Hispanic Community Health Study/Study of Latinos. Am J Hypertens. 2014;27:793–800.
Gu A, Yue Y, Desai RP, Argulian E. Racial and ethnic differences in antihypertensive medication use and blood pressure control among US adults with hypertension: the National Health and Nutrition Examination Survey, 2003 to 2012. Circ Cardiovasc Qual Outcomes. 2017;10:2105–14.
Ferdinand KC, Nasser SA. Understanding the importance of race/ethnicity in the care of the hypertensive patient. Curr Hypertens Rep. 2015;17:15.
Poon I, Lal LS, Ford ME, Braun UK. Racial/ethnic disparities in medication use among veterans with hypertension and dementia: a national cohort study. Ann Pharmacother. 2009;43:185–93.
Schoenthaler A, De La Calle F, Barrios-Barrios M, Garcia A, Pitaro M, Lum A, et al. A practice-based randomized controlled trial to improve medication adherence among Latinos with hypertension: study protocol for a randomized controlled trial. Trials. 2015;16:290.
Rodriguez CJ, Allison M, Daviglus ML, Isasi CR, Keller C, Leira EC, et al. Status of cardiovascular disease and stroke in Hispanics/Latinos in the United States: a science advisory from the American Heart Association. Circulation. 2014;130:593–625.
Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Himmelfarb CD, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71:e127–248.
Kronish IM, Leventhal H, Horowitz CR. Understanding minority patients’ beliefs about hypertension to reduce gaps in communication between patients and clinicians. J Clin Hypertens (Greenwich). 2012;14:38–44.
Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119:3028–35.
World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003.
Brown MT, Bussell JK. Medication adherence: WHO cares? Mayo Clin Proc. 2011;86:304–14.
Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008;336:1114–7.
Redmond N, Baer HJ, Hicks LS. Health behaviors and racial disparity in blood pressure control in the national health and nutrition examination survey. Hypertension. 2011;57:383–9.
Sudano JJ, Baker DW. Antihypertensive medication use in Hispanic adults: a comparison with black adults and white adults. Med Care. 2001;39:575–87.
Bandi P, Goldmann E, Parikh NS, Farsi P, Boden-Albala B. Age-related differences in antihypertensive medication adherence in Hispanics: a cross-sectional community-based survey in New York City, 2011-2012. Prev Chronic Dis. 2017;14:E57.
Rolnick SJ, Pawloski PA, Hedblom BD, Asche SE, Bruzek RJ. Patient characteristics associated with medication adherence. Clin Med Res. 2013;11:54–65.
Kretchy IA, Owusu-Daaku FT, Danquah SA. Mental health in hypertension: assessing symptoms of anxiety, depression and stress on anti-hypertensive medication adherence. Int J Ment Heal Syst. 2014;8:25–31.
Bautista LE, Vera-Cala LM, Colombo C, Smith P. Symptoms of depression and anxiety and adherence to antihypertensive medication. Am J Hypertens. 2012;25:505–11.
Phillips KD, Moneyham L, Murdaugh C, Boyd MR, Tavakoli A, Jackson K, et al. Sleep disturbance and depression as barriers to adherence. Clin Nurs Res. 2005;14:273–93.
McNaughton CD, Jacobson TA, Kripalani S. Low literacy is associated with uncontrolled blood pressure in primary care patients with hypertension and heart disease. Patient Educ Couns. 2014;96:165–70.
Berkman ND, Sheridan SL, Donahue KE, Halpern DJ, Crotty K. Low health literacy and health outcomes: an updated systematic review. Ann Intern Med. 2011;155:97–107.
Nutbeam D. Health promotion glossary. Health Promot. 1986;1:113–27.
Zhang NJ, Terry A, McHorney CA. Impact of health literacy on medication adherence: a systematic review and meta-analysis. Ann Pharmacother. 2014;48:741–51.
Yoon S, Suero-Tejeda N, Bakken S. A data mining approach for examining predictors of physical activity among urban older adults. J Gerontol Nurs. 2015;41:14–20.
Lee YJ, Boden-Albala B, Jia H, Wilcox A, Bakken S. The association between online health information-seeking behaviors and health behaviors among Hispanics in New York City: a community-based cross-sectional study. J Med Internet Res. 2015;17:e261.
Masterson Creber RM, Fleck E, Liu J, Rothenberg G, Ryan B, Bakken S. Identifying the complexity of multiple risk factors for obesity among urban Latinas. J Immigr Minor Health. 2017;19:275–84.
Sepulveda-Pacsi AL, Bakken S. Correlates of Dominicans’ identification of cancer as a worrisome health problem. J Immigr Minor Health. 2017;19:1227–34.
PROMIS Health Organization. PROMIS® measures are available in languages other than English. [Internet]. [cited 2018 Jun 12]. Available from: http://www.healthmeasures.net/explore-measurement-systems/promis/intro-to-promis/available-translations.
Health Literacy Tool Shed. Newest Vital Sign Spanish Version - NVS-SP [Internet]. 2005 [cited 2018 Jun 12]. Available from: https://healthliteracy.bu.edu/nvs-sp.
Weiss BD, Hart G, McGee DL, D’Estelle S. Health status of illiterate adults: relation between literacy and health status among persons with low literacy skills. J Am Board Fam Pract. 1992;5:257–64.
Pilkonis PA, Choi SW, Reise SP, Stover AM, Riley WT, Cella D, et al. Item banks for measuring emotional distress from the Patient-Reported Outcomes Measurement Information System (PROMIS®): depression, anxiety, and anger. Assessment. 2011;18:263–83.
Yu L, Buysse DJ, Germain A, Moul DE, Stover A, Dodds NE, et al. Development of short forms from the PROMIS™ sleep disturbance and sleep-related impairment item banks. Behav Sleep Med. 2011;10:6–24.
Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens. 2008;10:348–54.
Dunn-Navarra A-M, Stockwell MS, Meyer D, Larson E. Parental health literacy, knowledge and beliefs regarding upper respiratory infections (URI) in an urban Latino immigrant population. J Urban Health. 2012;89:848–60.
Institute of Medicine (US) Forum on the Science of Health Care Quality Improvement and Implementation, Institute of Medicine (US) Roundtable on Health Disparities, Institute of Medicine (US) Roundtable on Health Literacy. Toward Health Equity and Patient-Centeredness: Integrating Health Literacy, Disparities Reduction, and Quality Improvement: Workshop Summary [Internet]. Washington (DC): National Academies Press (US); 2009 [cited 2018 May 26]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK37533/.
Wali H, Hudani Z, Wali S, Mercer K, Grindrod K. A systematic review of interventions to improve medication information for low health literate populations. Res Soc Adm Pharm. 2016;12:830–64.
Tong X, Chu EK, Fang J, Wall HK, Ayala C. Nonadherence to antihypertensive medication among hypertensive adults in the United States─HealthStyles, 2010. J Clin Hypertens (Greenwich). 2016;18:892–900.
Lee GKY, Wang HHX, Liu KQL, Cheung Y, Morisky DE, Wong MCS. Determinants of medication adherence to antihypertensive medications among a Chinese population using Morisky Medication Adherence Scale. PLoS One. 2013;8:e62775.
Kripalani S, Gatti ME, Jacobson TA. Association of age, health literacy, and medication management strategies with cardiovascular medication adherence. Patient Educ Couns. 2010;81:177–81.
Insel K, Morrow D, Brewer B, Figueredo A. Executive function, working memory, and medication adherence among older adults. J Gerontol B Psychol Sci Soc Sci. 2006;61:P102–7.
Levinthal BR, Morrow DG, Tu W, Wu J, Murray MD. Cognition and health literacy in patients with hypertension. J Gen Intern Med. 2008;23:1172–6.
Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011;9:11–23.
Vawter L, Tong X, Gemilyan M, Yoon PW. Barriers to antihypertensive medication adherence among adults--United States, 2005. J Clin Hypertens (Greenwich). 2008;10:922–9.
Chen S-L, Lee W-L, Liang T, Liao I-C. Factors associated with gender differences in medication adherence: a longitudinal study. J Adv Nurs. 2014;70:2031–40.
Granger BB, Ekman I, Granger CB, Ostergren J, Olofsson B, Michelson E, et al. Adherence to medication according to sex and age in the CHARM programme. Eur J Heart Fail. 2009;11:1092–8.
Li W-W, Wallhagen MI, Froelicher ES. Factors predicting blood pressure control in older Chinese immigrants to the United States of America. J Adv Nurs. 2010;66:2202–12.
Grigoryan L, Pavlik VN, Hyman DJ. Predictors of antihypertensive medication adherence in two urban health-care systems. Am J Hypertens. 2012;25:735–8.
Holt E, Joyce C, Dornelles A, Morisky D, Webber LS, Muntner P, et al. Sex differences in barriers to antihypertensive medication adherence: findings from the cohort study of medication adherence among older adults (CoSMO). J Am Geriatr Soc. 2013;61:558–64.
Manias E, Bucknall T, Botti M. Assessment of patient pain in the postoperative context. West J Nurs Res. 2004;26:751–69.
Funding
The Washington Heights/Inwood Informatics Infrastructure for Comparative Effectiveness Research was supported by R01HS019853 and R01HS022961. The analysis and manuscript preparation were supported by the Reducing Health Disparities Through Informatics training grant (T32NR007969) and the Precision in Symptom Self-Management (PriSSM) Center (P30NR016587). Dr. Koleck is also supported by K99NR017651 and Dr. Navarra by K23 NR015970.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflicts of interest.
Ethical Approval
The study received IRB approval from the Columbia University Medical Center’s Institutional Review Board. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed Consent
Informed consent was obtained from all participants included in the study.
Animal Studies
No animal studies were carried out by the authors for this article.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Lor, M., Koleck, T.A., Bakken, S. et al. Association Between Health Literacy and Medication Adherence Among Hispanics with Hypertension. J. Racial and Ethnic Health Disparities 6, 517–524 (2019). https://doi.org/10.1007/s40615-018-00550-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40615-018-00550-z