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Population-level Patterns of Prostate Cancer Occurrence: Disparities in Virginia

  • Molecular Biology of Cell Death and Aging (N Razdan and N Muhammad, Section Editors)
  • Published:
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Abstract

Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths among men in the USA. In Virginia, which is a representative, ethnically diverse state of more than 8 million people that was established nearly 400 years ago, prostate cancer has the highest rate of new detection for any type of cancer. All men are at risk of developing prostate cancer regardless of demographics, but some men have an increased mortality risk due to cancer metastasis. Notably, one in five African American men will be diagnosed with prostate cancer in their lifetime and they have the highest prostate cancer mortality rate of any ethnic group in the USA, including Virginia. A person’s genetic profile and family history are important biological determinants of prostate cancer risk, but modifiable environmental factors (e.g., pollution) appear to be correlated with patterns of disease prevalence and risk. In this review, we examine current perspectives on population-level spatial patterns of prostate cancer in Virginia. For context, recent, publicly available data from the Centers for Disease Control and Prevention are highlighted and presented in spatial format. In addition, we explore possible co-morbidities of prostate cancer that may have demographic underpinnings highlighted in recent health disparity studies.

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Acknowledgements

We thank Dr. Luisel Ricks-Santi for assistance with obtaining publicly available registry data used in the assembly of this manuscript, as well as for conceptual input during the planning phases of this project.

Funding

Funding support was provided in part by the National Institute on Minority Health and Health Disparities (Award-U54MD008621, Subaward-190004 to EAL) and the National Science Foundation (HRD-1911928 to EAL; HRD-2000211 to CAB).

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Authors and Affiliations

  1. Department of Biological Sciences, Hampton University, Hampton, VA, USA

    Tunde M. Adebola, Herman W. W. Fennell, Michael D. Druitt, Carolina A. Bonin, Victoria A. Jenifer & Eric A. Lewallen

  2. Department of Biochemistry, University of Vermont, Burlington, VT, USA

    Andre J. van Wijnen

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  1. Tunde M. Adebola
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  2. Herman W. W. Fennell
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  3. Michael D. Druitt
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  4. Carolina A. Bonin
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  7. Eric A. Lewallen
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Correspondence to Carolina A. Bonin, Andre J. van Wijnen or Eric A. Lewallen.

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Ethics Approval

This review article included spatial analyses of data that are publicly available through the Centers for Disease Control and Prevention. The Institutional Review Board (IRB) at Hampton University determined that this project falls under “exempt category 4” and not subject to further ethical approval.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Author AJvW is the editor-in-chief, and authors CBL and EAL are section editors, of Current Molecular Biology Reports.

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Adebola, T.M., Fennell, H.W.W., Druitt, M.D. et al. Population-level Patterns of Prostate Cancer Occurrence: Disparities in Virginia. Curr Mol Bio Rep 8, 1–8 (2022). https://doi.org/10.1007/s40610-022-00147-w

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