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Severe Disease in Children with Parechovirus-A Infection

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Abstract

Purpose of Review

Parechovirus-A (PeV-A) is an important emerging virus. Clinical manifestations of pediatric PeV-A infection vary by genotype and range from mild acute illness to severe disease. This review discusses the global epidemiological profile of pediatric PeV-A infection and the relationship of PeV-A genotype to severe disease in neonates and young infants.

Recent Findings

In neonates and young infants the most important PeV-A3–associated conditions are sepsis and meningoencephalitis, which have been reported in many countries. The high morbidity of encephalitis due to PeV-A3 is a serious concern. Although rare, severe PeV-A–associated diseases due to other genotypes have also been reported in children. The pandemic of coronavirus disease 2019 significantly affected PeV-A3 detection.

Summary

PeV-A, especially PeV-A3, is an important emerging virus that causes severe disease in children. PeV-A genotyping will improve our understanding of the epidemiology of PeV-A and the relationship of PeV-A genotype with severe disease. Specific antiviral therapies are needed to treat severe diseases caused by PeV-A.

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Data Availability

The data and materials are available from the corresponding author upon reasonable request.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Aizawa Y, Izumita R, Saitoh A. Human parechovirus type 3 infection: An emerging infection in neonates and young infants. J Infect Chemother. 2017;23:419–26.

    Article  PubMed  Google Scholar 

  2. Harvala H, Robertson I, Chieochansin T, McWilliam Leitch EC, Templeton K, Simmonds P. Specific association of human parechovirus type 3 with sepsis and fever in young infants, as identified by direct typing of cerebrospinal fluid samples. J Infect Dis. 2009;199:1753–60.

    Article  CAS  PubMed  Google Scholar 

  3. Wigand R, Sabin AB. Properties of ECHO types 22, 23 and 24 viruses. Arch Gesamte Virusforsch. 1961;11:224–47.

    Article  CAS  PubMed  Google Scholar 

  4. Hyypia T, Horsnell C, Maaronen M, Khan M, Kalkkinen N, Auvinen P, et al. A distinct picornavirus group identified by sequence analysis. Proc Natl Acad Sci U S A. 1992;89:8847–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ghazi F, Hughes PJ, Hyypiä T, Stanway G. Molecular analysis of human parechovirus type 2 (formerly echovirus 23). J Gen Virol. 1998;79(Pt 11):2641–50.

    Article  CAS  PubMed  Google Scholar 

  6. Ito M, Yamashita T, Tsuzuki H, Takeda N, Sakae K. Isolation and identification of a novel human parechovirus. J Gen Virol. 2004;85:391–8.

    Article  CAS  PubMed  Google Scholar 

  7. Boivin G, Abed Y, Boucher FD. Human parechovirus 3 and neonatal infections. Emerg Infect Dis. 2005;11:103–5.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Schuffenecker I, Javouhey E, Gillet Y, Kugener B, Billaud G, Floret D, et al. Human parechovirus infections, Lyon, France, 2008-10: evidence for severe cases. J Clin Virol. 2012;54:337–41.

    Article  PubMed  Google Scholar 

  9. Selvarangan R, Nzabi M, Selvaraju SB, Ketter P, Carpenter C, Harrison CJ. Human parechovirus 3 causing sepsis-like illness in children from midwestern United States. Pediatr Infect Dis J. 2011;30:238–42.

    Article  PubMed  Google Scholar 

  10. Renaud C, Kuypers J, Ficken E, Cent A, Corey L, Englund JA. Introduction of a novel parechovirus RT-PCR clinical test in a regional medical center. J Clin Virol. 2011;51:50–3.

    Article  PubMed  Google Scholar 

  11. Walters B, Penaranda S, Nix WA, Oberste MS, Todd KM, Katz BZ, et al. Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area. J Clin Virol. 2011;52:187–91.

    Article  CAS  PubMed  Google Scholar 

  12. Felsenstein S, Yang S, Eubanks N, Sobrera E, Grimm JP, Aldrovandi G. Human parechovirus central nervous system infections in southern California children. Pediatr Infect Dis J. 2014;33:e87–91.

    Article  PubMed  Google Scholar 

  13. Midgley CM, Jackson MA, Selvarangan R, Franklin P, Holzschuh EL, Lloyd J, et al. Severe Parechovirus 3 Infections in Young Infants-Kansas and Missouri, 2014. J Pediatric Infect Dis Soc. 2018;7:104–12.

    Article  PubMed  Google Scholar 

  14. Sasidharan A, Banerjee D, Harrison CJ, Selvarangan R. Emergence of Parechovirus A3 as the Leading Cause of Central Nervous System Infection, Surpassing Any Single Enterovirus Type, in Children in Kansas City, Missouri, USA, from 2007 to 2016. J Clin Microbiol. 2021;59.

  15. Lee BR, Sasidharan A, Harrison CJ, Selvarangan R. Disruption of seasonal enterovirus and parechovirus detections in the CSF and plasma of children during the COVID-19 pandemic. J Clin Virol. 2023;160:105381. A recent study demonstrating an impact of COVID-19 on the detection of enterovirus and parechovirus from children in the US.

  16. Tao L, Humphries RM, Banerjee R, Gaston DC. Re-emergence of Parechovirus: 2017-2022 National Trends of Detection in Cerebrospinal Fluid. Open Forum Infect Dis. 2023;10:ofad112. A recent study demonstrating reemergence of parechovirus in CSF detected by multiplex PCR in the US.

  17. Harvala H, McLeish N, Kondracka J, McIntyre CL, McWilliam Leitch EC, Templeton K, et al. Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in edinburgh: HPeV type 3 identified as the most common picornavirus type. J Med Virol. 2011;83:889–96.

    Article  PubMed  Google Scholar 

  18. Skram MK, Skanke LH, Krokstad S, Nordbo SA, Nietsch L, Dollner H. Severe parechovirus infection in Norwegian infants. Pediatr Infect Dis J. 2014;33:1222–5.

    Article  PubMed  Google Scholar 

  19. de Jong EP, van den Beuken MGA, van Elzakker EPM, Wolthers KC, Sprij AJ, Lopriore E, et al. Epidemiology of Sepsis-like Illness in Young Infants: Major Role of Enterovirus and Human Parechovirus. Pediatr Infect Dis J. 2018;37:113–8.

    Article  PubMed  Google Scholar 

  20. Cabrerizo M, Díaz-Cerio M, Muñoz-Almagro C, Rabella N, Tarragó D, Romero MP, et al. Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain. J Med Virol. 2017;89:435–42.

    Article  CAS  PubMed  Google Scholar 

  21. Linhares MI, Brett A, Correia L, Pereira H, Correia C, Oleastro M, et al. Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal. Acta Med Port. 2021;34:664–8.

    Article  PubMed  Google Scholar 

  22. Elling R, Böttcher S, du Bois F, Müller A, Prifert C, Weissbrich B, et al. Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018. Emerg Infect Dis. 2019;25:1384–8.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Han TH, Chung JY, You SJ, Youn JL, Shim GH. Human parechovirus-3 infection in children. South Korea. J Clin Virol. 2013;58:194–9.

    Article  PubMed  Google Scholar 

  24. Aizawa Y, Watanabe K, Oishi T, Hirano H, Hasegawa I, Saitoh A. Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3. Emerg Infect Dis. 2015;21:1966–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Cumming G, Khatami A, McMullan BJ, Musto J, Leung K, Nguyen O, et al. Parechovirus Genotype 3 Outbreak among Infants, New South Wales, Australia, 2013-2014. Emerg Infect Dis. 2015;21:1144–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Nelson TM, Vuillermin P, Hodge J, Druce J, Williams DT, Jasrotia R, et al. An outbreak of severe infections among Australian infants caused by a novel recombinant strain of human parechovirus type 3. Sci Rep. 2017;7:44423.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Bialasiewicz S, May M, Tozer S, Day R, Bernard A, Zaugg J, et al. Novel Human Parechovirus 3 Diversity, Recombination, and Clinical Impact Across 7 Years: An Australian Story. J Infect Dis. 2023;227:278–87.

    Article  PubMed  Google Scholar 

  28. van der Sanden S, de Bruin E, Vennema H, Swanink C, Koopmans M, van der Avoort H. Prevalence of human parechovirus in the Netherlands in 2000 to 2007. J Clin Microbiol. 2008;46:2884–9.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Watanabe K, Hirokawa C, Tazawa T. Seropositivity and epidemiology of human parechovirus types 1, 3, and 6 in Japan. Epidemiol Infect. 2016;144:3451–60.

    Article  CAS  PubMed  Google Scholar 

  30. Aizawa Y, Kasamatsu T, Nagasawa K, Watanabe K, Saitoh A. Molecular Evolution and Epidemiology of Parechovirus-A3 in Japan, 1997-2019. J Infect Dis. 2023;227:288-294. A recent study demonstrating molecular evolution and epidemiology of PeV-A3 in Japan for the last 2 decades.

  31. Tao L, Fill MA, Banerjee R, Humphries RM. Notes from the Field: Cluster of Parechovirus Central Nervous System Infections in Young Infants - Tennessee, 2022. MMWR Morb Mortal Wkly Rep. 2022;71:977–8.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Olijve L, Jennings L, Walls T. Human Parechovirus: an Increasingly Recognized Cause of Sepsis-Like Illness in Young Infants. Clin Microbiol Rev. 2018;31.

  33. Sharp J, Bell J, Harrison CJ, Nix WA, Oberste MS, Selvarangan R. Human parechovirus in respiratory specimens from children in Kansas City, Missouri. J Clin Microbiol. 2012;50(12):4111–3.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Izumita R, Deuchi K, Aizawa Y, et al. Intrafamilial transmission of parechovirus A and enteroviruses in neonates and young infants. J Pediatric Infect Dis Soc. 2019;8(6):501–6.

    Article  PubMed  Google Scholar 

  35. Westerhuis BM, Jonker SC, Mattao S, Benschop KS, Wolthers KC. Growth characteristics of human parechovirus 1 to 6 on different cell lines and cross- neutralization of human parechovirus antibodies: a comparison of the cytopathic effect and real time PCR. Virol J. 2013;10:146.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Klatte JM, Harrison CJ, Pate B, Queen MA, Neuhart J, Jackson MA, et al. Maternal parechovirus A (PeV-A) shedding, serostatus, and the risk of central nervous system PeV-A infections in infants. J Clin Virol. 2021;142:104939.

    Article  PubMed  Google Scholar 

  37. Karelehto E, Wildenbeest JG, Benschop KSM, Koen G, Rebers S, Bouma-de Jongh S, et al. Human Parechovirus 1, 3 and 4 Neutralizing Antibodies in Dutch Mothers and Infants and Their Role in Protection Against Disease. Pediatr Infect Dis J. 2018;37:1304–8.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Tanaka S, Aoki Y, Matoba Y, Yahagi K, Itagaki T, Matsuzaki Y, et al. Seroepidemiology of human parechovirus types 1, 3, and 6 in Yamagata, Japan, in 2014. Microbiol Immunol. 2016;60:854–8.

    Article  CAS  PubMed  Google Scholar 

  39. Karelehto E, Brouwer L, Benschop K, Kok J, Basile K, McMullan B, et al. Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States. Emerg Infect Dis. 2019;25:148–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Shimizu H, Hashimoto K, Sato M, Sato A, Maeda H, Kyozuka H, et al. Association Between Neutralizing Antibody Titers against Parechovirus A3 in Maternal and Cord Blood Pairs and Perinatal Factors. J Pediatric Infect Dis Soc. 2020;9:320–5.

    Article  CAS  PubMed  Google Scholar 

  41. Mizuta K, Komabayashi K, Aoki Y, Itagaki T, Ikeda T. Seroprevalence of parechovirus A1, A3 and A4 antibodies in Yamagata, Japan, between 1976 and 2017. J Med Microbiol. 2020;69:1381–7.

    Article  PubMed  Google Scholar 

  42. Izumita R, Aizawa Y, Watanabe K, Saitoh A. Persistence of High Neutralizing Antibody Titers After Neonatal and Early Infantile Infection with Parechovirus-A3. Pediatr Infect Dis J. 2019;38:e159–61.

    Article  PubMed  Google Scholar 

  43. Kadambari S, Harvala H, Simmonds P, Pollard AJ, Sadarangani M. Strategies to improve detection and management of human parechovirus infection in young infants. Lancet Infect Dis. 2019;19:e51–8.

    Article  PubMed  Google Scholar 

  44. Aizawa Y, Suzuki Y, Watanabe K, Oishi T, Saitoh A. Clinical utility of serum samples for human parechovirus type 3 infection in neonates and young infants: The 2014 epidemic in Japan. J Infect. 2016;72:223–32.

    Article  PubMed  Google Scholar 

  45. Khatami A, McMullan BJ, Webber M, Stewart P, Francis S, Timmers KJ, et al. Sepsis-like disease in infants due to human parechovirus type 3 during an outbreak in Australia. Clin Infect Dis. 2015;60:228–36.

    Article  PubMed  Google Scholar 

  46. Bangalore H, Ahmed J, Bible J, Menson EN, Durward A, Tong CY. Abdominal distension: an important feature in human parechovirus infection. Pediatr Infect Dis J. 2011;30:260–2.

    Article  PubMed  Google Scholar 

  47. Watanabe T, Takahashi M, Shoji K, Yamada K, Yamada W, Tanaka H, et al. Human parechovirus-3 infection mimicking Hirschsprung-associated enterocolitis. Journal of Pediatric Surgery Case Reports. 2014;2:58–60.

    Article  Google Scholar 

  48. Shoji K, Komuro H, Miyata I, Miyairi I, Saitoh A. Dermatologic manifestations of human parechovirus type 3 infection in neonates and infants. Pediatr Infect Dis J. 2013;32:233–6.

    Article  PubMed  Google Scholar 

  49. Shoji K, Komuro H, Kobayashi Y, Shike T, Funaki T, Katsuta T, et al. An infant with human parechovirus type 3 infection with a distinctive rash on the extremities. Pediatr Dermatol. 2014;31:258–9.

    Article  PubMed  Google Scholar 

  50. Ristagno EH, Marshall GS. Mittens and Booties Syndrome: A Unique Manifestation of Human Parechovirus Infection in Infants. Pediatr Infect Dis J. 2019;38:e223–5.

    Article  PubMed  Google Scholar 

  51. Nirei J, Aizawa Y, Okazaki M, Kobayashi A, Onozuka J, Numata O, et al. Human parechovirus type 3 infection: Cause of apnea in infants born prematurely. Pediatr Int. 2016;58:400–2.

    Article  CAS  PubMed  Google Scholar 

  52. Jaaskelainen AJ, Kolehmainen P, Kallio-Kokko H, Nieminen T, Koskiniemi M, Tauriainen S, et al. First two cases of neonatal human parechovirus 4 infection with manifestation of suspected sepsis Finland. J Clin Virol. 2013;58:328–30.

    Article  PubMed  Google Scholar 

  53. Piralla A, Perniciaro S, Ossola S, Giardina F, De Carli A, Bossi A, et al. Human parechovirus type 5 neurological infection in a neonate with a favourable outcome: A case report. Int J Infect Dis. 2019;89:175–8.

    Article  PubMed  Google Scholar 

  54. Chamings A, Liew KC, Reid E, Athan E, Raditsis A, Vuillermin P, et al. An Emerging Human Parechovirus Type 5 Causing Sepsis-Like Illness in Infants in Australia. Viruses. 2019;11.

  55. Kolehmainen P, Jaaskelainen A, Blomqvist S, Kallio-Kokko H, Nuolivirta K, Helminen M, et al. Human parechovirus type 3 and 4 associated with severe infections in young children. Pediatr Infect Dis J. 2014;33:1109–13.

    Article  PubMed  Google Scholar 

  56. Wolthers KC, Benschop KS, Schinkel J, Molenkamp R, Bergevoet RM, Spijkerman IJ, et al. Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children. Clin Infect Dis. 2008;47:358–63.

    Article  PubMed  Google Scholar 

  57. Ghanem-Zoubi N, Shiner M, Shulman LM, Sofer D, Wolf D, Marva E, et al. Human parechovirus type 3 central nervous system infections in Israeli infants. J Clin Virol. 2013;58:205–10.

    Article  CAS  PubMed  Google Scholar 

  58. Arai S, Yamanaka T, Kasai M, Fukuyama T, Aizawa Y, Matsui K, et al. Parechovirus-A3 encephalitis presenting with focal seizure mimicking herpes simplex virus infection. J Infect Chemother. 2020;26:736–40.

    Article  CAS  PubMed  Google Scholar 

  59. Verboon-Maciolek MA, Groenendaal F, Hahn CD, Hellmann J, van Loon AM, Boivin G, et al. Human parechovirus causes encephalitis with white matter injury in neonates. Ann Neurol. 2008;64:266–73.

    Article  PubMed  Google Scholar 

  60. Britton PN, Dale RC, Nissen MD, Crawford N, Elliott E, Macartney K, et al. Parechovirus Encephalitis and Neurodevelopmental Outcomes. Pediatrics. 2016;137:e20152848.

    Article  PubMed  Google Scholar 

  61. DeArias AL, McAllister L, Bamford NS. Neonatal Human Parechovirus Encephalitis: A Case of Rapid and Fatal Gliosis. Pediatr Neurol. 2023;140:1–2.

    Article  PubMed  Google Scholar 

  62. van Zwol AL, Lequin M, Aarts-Tesselaar C, van der Eijk AA, Driessen GA, de Hoog M, et al. Fatal neonatal parechovirus encephalitis. BMJ Case Rep. 2009;2009.

  63. Bissel SJ, Auer RN, Chiang CH, Kofler J, Murdoch GH, Nix WA, et al. Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy. J Neuropathol Exp Neurol. 2015;74:767–77.

    Article  PubMed  Google Scholar 

  64. Sedmak G, Nix WA, Jentzen J, Haupt TE, Davis JP, Bhattacharyya S, et al. Infant deaths associated with human parechovirus infection in Wisconsin. Clin Infect Dis. 2010;50:357–61.

    Article  PubMed  Google Scholar 

  65. Hayashi Y, Odagiri T, Echizenya T, Dewa K, Muraki Y. Isolation of human parechovirus type 3 from an infant with sudden death. Pediatr Int. 2022;64:e15305.

    Article  PubMed  Google Scholar 

  66. Yuzurihara SS, Ao K, Hara T, Tanaka F, Mori M, Kikuchi N, et al. Human parechovirus-3 infection in nine neonates and infants presenting symptoms of hemophagocytic lymphohistiocytosis. J Infect Chemother. 2013;19:144–8.

    Article  PubMed  Google Scholar 

  67. Nimura K, Maruyama Y, Aizawa Y, Saitoh A, Nakazawa Y. Changes in laboratory findings in Parechovirus-A infection in nine neonates and infants. Pediatr Int. 2020;62:755–8.

    Article  PubMed  Google Scholar 

  68. Hara S, Kawada J, Kawano Y, Yamashita T, Minagawa H, Okumura N, et al. Hyperferritinemia in neonatal and infantile human parechovirus-3 infection in comparison with other infectious diseases. J Infect Chemother. 2014;20:15–9.

    Article  CAS  PubMed  Google Scholar 

  69. Casas-Alba D, Martinez-Monseny A, Monfort L, Munoz-Almagro C, Cabrerizo M, Deya A, et al. Extreme Hyperferritinemia in Dizygotic Twins With Human Parechovirus-3 Infection. Pediatr Infect Dis J. 2016;35:1366–8.

    Article  PubMed  Google Scholar 

  70. Aviner S, Sofer D, Shulman LM, Bibi H, Weitzman S. Hemophagocytic lymphohistiocytosis associated with parechovirus 3 infection. J Pediatr Hematol Oncol. 2014;36:e251–3.

    Article  PubMed  Google Scholar 

  71. Wildenbeest JG, Wolthers KC, Straver B, Pajkrt D. Successful IVIG treatment of human parechovirus-associated dilated cardiomyopathy in an infant. Pediatrics. 2013;132:e243–7.

    Article  PubMed  Google Scholar 

  72. Maki S, Aizawa Y, Ito Y, Suda M, Saitoh A. Acute heart failure due to dilated cardiomyopathy exacerbated by systemic parechovirus A1 infection in an infant. Int J Infect Dis. 2021;104:273–5.

    Article  PubMed  Google Scholar 

  73. Mardekian SK, Fortuna D, Nix A, Bhatti T, Wiley CA, Flanders A, et al. Severe human parechovirus type 3 myocarditis and encephalitis in an adolescent with hypogammaglobulinemia. Int J Infect Dis. 2015;36:6–8.

    Article  PubMed  Google Scholar 

  74. Bigelow AM, Scott JP, Hong JC, Cronin DC, Vitola BE, Fons RA, et al. Human Parechovirus as a Cause of Isolated Pediatric Acute Liver Failure. Pediatr. 2016;138.

  75. Levorson RE, Jantausch BA, Wiedermann BL, Spiegel HM, Campos JM. Human parechovirus-3 infection: emerging pathogen in neonatal sepsis. Pediatr Infect Dis J. 2009;28:545–7.

    Article  PubMed  Google Scholar 

  76. K AM, C D, C A. “Twin” viruses. J Clin Virol. 2009;44:vi, I.

  77. Watanabe K, Oie M, Higuchi M, Nishikawa M, Fujii M. Isolation and characterization of novel human parechovirus from clinical samples. Emerg Infect Dis. 2007;13:889–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Black S, Bradley C, Lai FY, Shenoy S, Bandi S, Allen DJ, et al. Comparing the Clinical Severity of Disease Caused by Enteroviruses and Human Parechoviruses in Neonates and Infants. Pediatr Infect Dis J. 2019;38:e36–8.

    Article  PubMed  Google Scholar 

  79. Izumita R, Aizawa Y, Habuka R, Watanabe K, Otsuka T, Kitamura N, et al. Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants. J Clin Virol. 2020;124:104256.

    Article  CAS  PubMed  Google Scholar 

  80. Suzuki Y, Aizawa Y, Izumita R, Habuka R, Watanabe K, Saitoh A. PCR detection rates for serum and cerebrospinal fluid from neonates and young infants infected with human parechovirus 3 and enteroviruses. J Clin Virol. 2021;135:104736.

    Article  CAS  PubMed  Google Scholar 

  81. Britton PN, Walker K, McMullan B, Galea C, Burrell R, Morgan B, et al. Early Life Parechovirus Infection Neurodevelopmental Outcomes at 3 Years: A Cohort Study. J Pediatr. 2020;219:111–7. e111

  82. Joseph L, May M, Thomas M, Smerdon C, Tozer S, Bialasiewicz S, et al. Human Parechovirus 3 in Infants: Expanding Our Knowledge of Adverse Outcomes. Pediatr Infect Dis J. 2019;38:1–5.

    Article  PubMed  Google Scholar 

  83. de Ceano-Vivas M, García ML, Velázquez A, Martín Del Valle F, Menasalvas A, Cilla A, et al. Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System. Front Pediatr. 2021;9:719119. A recent paper demonstrating poor neurolodevelopmental outcomes of PeV-A and enterovirus CNS infection in neonates and young infants.

  84. Britton PN, Khandaker G, Khatami A, Teutsch S, Francis S, McMullan BJ, et al. High prevalence of developmental concern amongst infants at 12 months following hospitalised parechovirus infection. J Paediatr Child Health. 2018;54:289–95.

    Article  PubMed  Google Scholar 

  85. van Hinsbergh TMT, Elbers RG, Hans Ket JCF, van Furth AM, Obihara CC. Neurological and neurodevelopmental outcomes after human parechovirus CNS infection in neonates and young children: a systematic review and meta-analysis. Lancet Child Adolesc Health. 2020;4:592-605. A recent paper reviewing neurological and developmental outcomes of PeV-A encephalitis in neonates and young infants.

  86. Wildenbeest JG, Harvala H, Pajkrt D, Wolthers KC. The need for treatment against human parechoviruses: how, why and when? Expert Rev Anti Infect Ther. 2010;8:1417–29.

    Article  PubMed  Google Scholar 

  87. Watanabe K, Oka T, Takagi H, Anisimov S, Yamashita SI, Katsuragi Y, et al. Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry. Nat Commun. 2023;14:1817. A recent paper identifying myeloid associated differentiation marker as a novel cell curface protein for the entry of PeV-A.

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Funding

This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science [Number 21KK0166] to AS and a JSPS KAKENHI Grant [Number JP23K14969] to YA.

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  1. Jun Tachikawa and Yuta Aizawa have contributed equally to this work.

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  1. Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan

    Jun Tachikawa, Yuta Aizawa & Akihiko Saitoh

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JT, YA wrote the manuscript draft and AS revised the manuscript. JT created the figure. All authors reviewed and approved the final version of the manuscript.

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Correspondence to Akihiko Saitoh.

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Tachikawa, J., Aizawa, Y. & Saitoh, A. Severe Disease in Children with Parechovirus-A Infection. Curr Clin Micro Rpt 10, 75–84 (2023). https://doi.org/10.1007/s40588-023-00197-3

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