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Asthma and Cleaning: What’s New?

  • Occupational Allergy (S Quirce and J Sastre, Section Editors)
  • Published:
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Abstract

Professional and domestic cleanings are associated with work-related asthma (WRA). Increased risk of asthma has been shown in many epidemiological and surveillance studies, and several case reports describe the relationship between exposure to one or more cleaning agents and WRA. Moreover, exposure to cleaning chemicals could be associated with severe uncontrolled asthma. Cleaning sprays, bleach, ammonia, disinfectants, mixing products, and specific job tasks have been identified as specific causes and/or triggers of asthma or airway respiratory diseases. Their measurements at the workplace could be interesting but hardly feasible. It is still under controversy whether cleaning products are airway irritants or sensitizers. The social consequence of unemployment in this population is one of the most important limitations to the management of occupational in cleaning professionals. The prognosis of the disease depends of removal from exposure, with avoidance of high-risk cleaning products, even at home.

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  1. Torén K, Blanc PD. Asthma caused by occupational exposures is common—a systematic analysis of estimates of the population-attributable fraction. BMC Pulm Med. 2009;9:7.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mäkelä R, Kauppi P, Suuronen K, Tuppurainen M, Hannu T. Occupational asthma in professional cleaning work: a clinical study. Occup Med. 2011;61(2):121–6.

    Article  Google Scholar 

  3. Le Moual N, Varraso R, Siroux V, Dumas O, Nadif R, Pin I, et al. Domestic use of cleaning sprays and asthma activity in females. Eur Respir J. 2012;40(6):1381–9.

    Article  PubMed  Google Scholar 

  4. •Quirce S, Barranco P. Cleaning agents and asthma. J Investig Allergol Clin Immunol. 2010;20(7):542–50. quiz 2p following 550. Interesting review about cleaning agents and asthma

  5. De Matteis S, Cullinan P. Occupational asthma in cleaners: a challenging black box. Vol. 72. 2015.

  6. Vizcaya D, Mirabelli MC, Antó J-M, Orriols R, Burgos F, Arjona L, et al. A workforce-based study of occupational exposures and asthma symptoms in cleaning workers. Occup Env Med. 2011;68(12):914–9.

    Article  Google Scholar 

  7. Bello A, Quinn MM, Perry MJ, Milton DK. Characterization of occupational exposures to cleaning products used for common cleaning tasks-a pilot study of hospital cleaners. Environ Health. 2009;8:11.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Arif AA, Delclos GL. Association between cleaning-related chemicals and work-related asthma and asthma symptoms among healthcare professionals. Occup Environ Med. 2011;oem.2011.064865.

  9. •• Siracusa A, De Blay F, Folletti I, Moscato G, Olivieri M, Quirce S, et al. Asthma and exposure to cleaning products—a European Academy of Allergy and Clinical Immunology task force consensus statement. Allergy. 2013;68(12):1532–45. State of art about asthma and exposure cleaning written by agroup of European experts

  10. Melchior Gerster F, Brenna Hopf N, Pierre Wild P, Vernez D. Airborne exposures to monoethanolamine, glycol ethers, and benzyl alcohol during professional cleaning: a pilot atudy. Ann Occup Hyg. 2014 Aug 1;58(7):846–59.

    PubMed  Google Scholar 

  11. Dumas O, Siroux V, Luu F, Nadif R, Zock J-P, Kauffmann F, et al. Cleaning and asthma characteristics in women. Am J Ind Med. 2014;57(3):303–11.

    Article  PubMed  Google Scholar 

  12. Zock J-P, Plana E, Jarvis D, Antó JM, Kromhout H, Kennedy SM, et al. The use of household cleaning sprays and adult asthma. Am J Respir Crit Care Med. 2007;176(8):735–41.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Vizcaya D, Mirabelli MC, Gimeno D, Antó J-M, Delclos GL, Rivera M, et al. Cleaning products and short-term respiratory effects among female cleaners with asthma. Occup Env Med. 2015;oemed-2013-102,046.

  14. Vincent G, Kopferschmitt-Kubler MC, Mirabel P, Pauli G, Millet M. Sampling and analysis of quaternary ammonium compounds (QACs) traces in indoor atmosphere. Environ Monit Assess. 2007;133(1–3):25–30.

    Article  CAS  PubMed  Google Scholar 

  15. Le Moual N, Jacquemin B, Varraso R, Dumas O, Kauffmann F, Nadif R. Environment and asthma in adults. Presse Medicale Paris Fr 1983. 2013;42(9 Pt 2):e317–33.

    Google Scholar 

  16. Vizcaya D, Mirabelli MC, Orriols R, Antó JM, Barreiro E, Burgos F, et al. Functional and biological characteristics of asthma in cleaning workers. Respir Med. 2013;107(5):673–83.

    Article  PubMed  Google Scholar 

  17. Zhu J, Li H, Korchinski M, Fellin P. Prediction of initial emission rates of 2-butoxyethanol from consumer products using equilibrium headspace concentrations: an application of the vapor pressure and boundary layer (VB) model. Environ Sci Technol. 2005;39(21):8214–9.

    Article  CAS  PubMed  Google Scholar 

  18. Zhu J, Cao XL, Beauchamp R. Determination of 2-butoxyethanol emissions from selected consumer products and its application in assessment of inhalation exposure associated with cleaning tasks. Environ Int. 2001;26(7–8):589–97.

    Article  CAS  PubMed  Google Scholar 

  19. • Kogevinas M, Antó JM, Sunyer J, Tobias A, Kromhout H, Burney P. Occupational asthma in Europe and other industrialised areas: a population-based study. The Lancet. 1999;353(9166):1750–4.Large and interesting European epidemiological study on cleaning and asthma

  20. Kogevinas M, Zock J-P, Jarvis D, Kromhout H, Lillienberg L, Plana E, et al. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet Lond Engl. 2007;370(9584):336–41.

    Article  CAS  Google Scholar 

  21. Dumas O, Laurent E, Bousquet J, Metspalu A, Milani L, Kauffmann F, et al. Occupational irritants and asthma: an Estonian cross-sectional study of 34,000 adults. Eur Respir J. 2014;44(3):647–56.

    Article  PubMed  Google Scholar 

  22. Brun E. The occupational safety and health of cleaning workers EU-OSHA. Luxembourg: Office for Official Publications of the European Communities: European Agency for Safety and Health at Work. 2009.

  23. Siracusa A, Marabini A, Folletti I, Moscato G. Smoking and occupational asthma. Clin Exp Allergy J Br Soc Allergy. Clin Immunol. 2006;36(5):577–84.

    CAS  Google Scholar 

  24. Radon K, Llanqui U, Arce A, Herrera R, Herbig B, Nowak D, et al. Job strain, bullying and violence at work and asthma in Peruvian cleaners-a cross-sectional analysis. J Asthma Off J Assoc Care Asthma. 2016;53(10):1018–25.

    Article  Google Scholar 

  25. Svanes Ø, Skorge TD, Johannessen A, Bertelsen RJ, Bråtveit M, Forsberg B, et al. Respiratory health in cleaners in Northern Europe: is susceptibility established in early life? PloS One. 2015;10(7):e0131959.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Fell AK, Abrahamsen R, Henneberger PK, Svendsen MV, Andersson E, Torén K, et al. Breath-taking jobs: a case-control study of respiratory work disability by occupation in Norway. Occup Environ Med. 2016;73(9):600–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Lipinska-Ojrzanowska AA, Wiszniewska M, Walusiak-Skorupa JM. Work-related asthma among professional cleaning women. Arch Environ Occup Health. 2017;72(1):53–60.

    Article  CAS  PubMed  Google Scholar 

  28. Matulonga B, Rava M, Siroux V, Bernard A, Dumas O, Pin I, et al. Women using bleach for home cleaning are at increased risk of non-allergic asthma. Respir Med. 2016;117:264–71.

    Article  PubMed  Google Scholar 

  29. Quinot C, Dumas O, Henneberger PK, Varraso R, Wiley AS, Speizer FE, et al. Development of a job-task-exposure matrix to assess occupational exposure to disinfectants among US nurses. Occup Environ Med. 2017;74(2):130–7.

    Article  CAS  PubMed  Google Scholar 

  30. Gonzalez M, Jégu J, Kopferschmitt M-C, Donnay C, Hedelin G, Matzinger F, et al. Asthma among workers in healthcare settings: role of disinfection with quaternary ammonium compounds. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2014;44(3):393–406.

    Article  CAS  Google Scholar 

  31. • Dumas O, Wiley AS, Henneberger PK, Speizer FE, Zock J-P, Varraso R, et al. Determinants of disinfectant use among nurses in U.S. healthcare facilities. Am J Ind Med. 2017;60(1):131–40.Large and interesting epidemiological study on nurses and asthma

  32. Dumas O, Wiley AS, Quinot C, Varraso R, Zock J-P, Henneberger PK, et al. Occupational exposure to disinfectants and asthma control in US nurses. Eur Respir J. 2017;50(4).

  33. Dumas O, Varraso R, Zock JP, Henneberger PK, Speizer FE, Wiley AS, et al. Asthma history, job type and job changes among US nurses. Occup Environ Med. 2015;72(7):482–8.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Redlich CA, Herrick CA. Lung/skin connections in occupational lung disease. Curr Opin Allergy Clin Immunol. 2008;8(2):115–9.

    Article  CAS  PubMed  Google Scholar 

  35. Lynde CB, Obadia M, Liss GM, Ribeiro M, Holness DL, Tarlo SM. Cutaneous and respiratory symptoms among professional cleaners. Occup Med. 2009;59(4):249–54.

    Article  Google Scholar 

  36. Maestrelli P, Boschetto P, Fabbri LM, Mapp CE. Mechanisms of occupational asthma. J Allergy Clin Immunol. 2009;123(3):531–42.

    Article  PubMed  Google Scholar 

  37. Malo J-L, Chan-Yeung M. Agents causing occupational asthma. J Allergy Clin Immunol. 2009;123(3):545–50.

    Article  CAS  PubMed  Google Scholar 

  38. Purohit A, Kopferschmitt-Kubler MC, Moreau C, Popin E, Blaumeiser M, Pauli G. Quaternary ammonium compounds and occupational asthma. Int Arch Occup Environ Health. 2000;73(6):423–7.

    Article  CAS  PubMed  Google Scholar 

  39. Larsen ST, Hansen JS, Hansen EW, Clausen PA, Nielsen GD. Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice. Toxicology. 2007;235(1–2):119–29.

    Article  CAS  PubMed  Google Scholar 

  40. Preller L, Doekes G, Heederik D, Vermeulen R, Vogelzang PF, Boleij JS. Disinfectant use as a risk factor for atopic sensitization and symptoms consistent with asthma: an epidemiological study. Eur Respir J. 1996;9(7):1407–13.

    Article  CAS  PubMed  Google Scholar 

  41. Wu Y, You H, Ma P, Li L, Yuan Y, Li J, et al. Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice. PloS One. 2013;8(5):e62827.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Casset A, Marchand C, Purohit A, le Calve S, Uring-Lambert B, Donnay C, et al. Inhaled formaldehyde exposure: effect on bronchial response to mite allergen in sensitized asthma patients. Allergy. 2006;61(11):1344–50.

    Article  CAS  PubMed  Google Scholar 

  43. • Vandenplas O, D’Alpaos V, Evrard G, Jamart J. Incidence of severe asthmatic reactions after challenge exposure to occupational agents. Chest. 2013;143(5):1261–8.Study on specific inhalation challenge in patients with a suspicion of occupational asthma to cleaning products

  44. Zock JP, Kogevinas M, Sunyer J, Jarvis D, Torén K, Antó JM. Asthma characteristics in cleaning workers, workers in other risk jobs and office workers. Eur Respir J. 2002;20(3):679–85.

    Article  CAS  PubMed  Google Scholar 

  45. Medina-Ramón M, Zock JP, Kogevinas M, Sunyer J, Basagaña X, Schwartz J, et al. Short-term respiratory effects of cleaning exposures in female domestic cleaners. Eur Respir J. 2006;27(6):1196–203.

    Article  PubMed  Google Scholar 

  46. Zholos AV. TRP channels in respiratory pathophysiology: the role of oxidative, chemical irritant and temperature stimuli. Curr Neuropharmacol. 2015;13(2):279–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Martin JG, Campbell HR, Iijima H, Gautrin D, Malo J-L, Eidelman DH, et al. Chlorine-induced injury to the airways in mice. Am J Respir Crit Care Med. 2003;168(5):568–74.

    Article  PubMed  Google Scholar 

  48. Corradi M, Gergelova P, Pilato ED, Folesani G, Goldoni M, Andreoli R, et al. Effect of exposure to detergents and other chemicals on biomarkers of pulmonary response in exhaled breath from hospital cleaners: a pilot study. Int Arch Occup Environ Health. 2012;85(4):389–96.

    Article  CAS  PubMed  Google Scholar 

  49. Dumas O, Matran R, Zerimech F, Decoster B, Huyvaert H, Ahmed I, et al. Occupational exposures and fluorescent oxidation products in 723 adults of the EGEA study. Eur Respir J. 2015;46(1):258–61.

    Article  CAS  PubMed  Google Scholar 

  50. Aldakheel FM, Thomas PS, Bourke JE, Matheson MC, Dharmage SC, Lowe AJ. Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate: a systematic review. Allergy. 2016;71(6):741–57.

    Article  CAS  PubMed  Google Scholar 

  51. Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, et al. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three european studies. Environ Health Perspect. 2017;125(2):207–14.

    PubMed  Google Scholar 

  52. Tarlo SM, Balmes J, Balkissoon R, Beach J, Beckett W, Bernstein D, et al. Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement. Chest. 2008;134(3 Suppl):1S–41S.

    Article  CAS  PubMed  Google Scholar 

  53. Ternesten-Hasséus E, Lowhagen O, Millqvist E. Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal study. Environ Health Perspect. 2007;115(3):425–9.

    Article  PubMed  Google Scholar 

  54. Abraham MH, Sánchez-Moreno R, Cometto-Muñiz JE, Cain WS. A quantitative structure—activity analysis on the relative sensitivity of the olfactory and the nasal trigeminal chemosensory systems. Chem Senses. 2007;32(7):711–9.

    Article  CAS  PubMed  Google Scholar 

  55. Johansson A, Millqvist E, Bende M. Relationship of airway sensory hyperreactivity to asthma and psychiatric morbidity. Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol. 2010;105(1):20–3.

    Article  Google Scholar 

  56. • Zock J-P, Vizcaya D, Le Moual N. Update on asthma and cleaners. Curr Opin Allergy Clin Immunol. 2010;10(2):114–20.State of art about asthma and cleaners

  57. Lee S-J, Nam B, Harrison R, Hong O. Acute symptoms associated with chemical exposures and safe work practices among hospital and campus cleaning workers: a pilot study. Am J Ind Med. 2014;57(11):1216–26.

    Article  PubMed  Google Scholar 

  58. Fishwick D, Barber CM, Bradshaw LM, Ayres JG, Barraclough R, Burge S, et al. Standards of care for occupational asthma: an update. Thorax. 2012;67(3):278–80.

    Article  PubMed  Google Scholar 

  59. Baur X, Aasen TB, Burge PS, Heederik D, Henneberger PK, Maestrelli P, et al. The management of work-related asthma guidelines: a broader perspective. Eur Respir Rev. Off J Eur Respir Soc. 2012;21(124):125–39.

    Google Scholar 

  60. • Olivier Vandenplas, Hille Suojalehto, Paul Cullinan. Diagnosing occupational asthma. 2016.State of art about specific inhalation challenge written a group of European experts

  61. • Bellier M, Barnig C, Renaudin JM, Sbinne B, Lefebvre F, Qi S, et al. Importance of specific inhalation challenge in the diagnosis of occupational asthma induced by quaternary ammonium compounds. J Allergy Clin Immunol Pract. 2015;3(5):819–20.Study on specific inhalation challenge in patients with a suspicion of occupational asthma to quaternary ammonium

  62. Sastre J, Madero MF, Fernández-Nieto M, Sastre B, del Pozo V, Potro MG, et al. Airway response to chlorine inhalation (bleach) among cleaning workers with and without bronchial hyperresponsiveness. Am J Ind Med. 2011;54(4):293–9.

    Article  PubMed  Google Scholar 

  63. D’Alessandro A, Kuschner W, Wong H, Boushey HA, Blanc PD. Exaggerated responses to chlorine inhalation among persons with nonspecific airway hyperreactivity. Chest. 1996109(2):331–337.

  64. • Munoz X, Viladrich M, Manso L, del Pozo V, Quirce S, Cruz MJ, et al. Evolution of occupational asthma: does cessation of exposure really improve prognosis? Respir Med. 2014108(9):1363–1370.Sztudy on evolution of occupational asthma

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Correspondence to Frederic de Blay MD.

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Frederic de Blay reports grants from STALLERGENES-GREER, grants from CHIESI, personal fees from ALK, personal fees from MUNDIPHARMA, personal fees from NOVARTIS, during the conduct of the study; other from STALLERGENES-GREER, other from NOVARTIS, other from ALK, other from MUNDIPHARMA, other from MEDAPHARMA, other from BOEHRINGER, other from ASTRAZENECA, outside the submitted work.

Carole Ederle declares that she has no conflict of interest.

Carole Donnay declares that she has no conflict of interest.

Naji Khayath declares that he has no conflict of interest.

Marie Mielcarek declares that she has no conflict of interest.

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Ederle, C., Donnay, C., Khayath, N. et al. Asthma and Cleaning: What’s New?. Curr Treat Options Allergy 5, 29–40 (2018). https://doi.org/10.1007/s40521-018-0153-9

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