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Intrinsic capacity and 5-year late-life functional ability trajectories of Chinese older population using ICOPE tool: the Rugao Longevity and Ageing Study

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Abstract

Background and aims

Knowledge of how intrinsic capacity (IC) shape functional ability (FA) trajectories in later life remains unclear. We investigated the changes in IC and their impact on 5-years FA trajectories in the Chinese older population.

Methods

A total of 1640 older adults from the Rugao Longitudinal Ageing Study were included and analyzed. FA was assessed by The Lawton Instrumental Activities of Daily Living Scale (IADLs). We used cognition, psychology, locomotion, sensory capacity, and vitality to capture the multiple domains of IC according to the ICOPE method. The IC was derived retrospectively from variables collected before this was described by WHO.

Results

At baseline, a higher IC was associated with higher IADLs (β = 0.98, 95% CI 0.90, 1.06, P < 0.001). Individuals with declines in IC between wave1 and wave2 experienced a faster decline in IADLs over time (β = − 0.28, 95% CI − 0.40, − 0.16, P < 0.001) after considering covariates. One or more impairment IC scores at baseline strongly predicted death (HR = 1.20, 95% CI 1.11, 1.30, P < 0.001). In addition, according to the IC scores at baseline, we stratify IC in low, middle, and high, compared with those in the high IC score, those in the low were associated with a 2.56-fold (95% CI 1.64, 4.01, P < 0.001) higher risk of mortality, after adjustment for variables.

Conclusion

Changes in IC shape FA trajectories. IC impairment is associated with an increased risk of death. Assessing intrinsic capacity would facilitate early identification of older adults at high risk of adverse outcomes and prompt targeted interventions.

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Data availability

The RLAS data are available upon request, following validation of a research proposal, from xiaofengwang@fudan.edu.cn.

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Acknowledgements

The authors acknowledge all participants involved in the present study from the RuLAS. They acknowledge the support from the government of Rugao, the Public Health Bureau of Jiang’an Township and Rugao city, the Bureau of Civil Affairs, the Rugao People’s Hospital, and Human Phenome Institute, Fudan University, Shanghai, China.

Funding

This work was financially supported by grants from the National Key R&D Program of China (2018YFC2000400, 2018YFC2002000), the National Natural Science Foundation of China (81670465,81600577), Shanghai Municipal Science and Technology Major Project (2017SHZDZX01), National Science Foundation of China (32288101), and CAMS Innovation Fund for Medical Sciences (2019-I2M-5-066).

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Authors and Affiliations

  1. MOE Key Laboratory of Contemporary Anthropology and School of Life Science and Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    Na Zhang, Jiu-Cun Wang & Xiao-Feng Wang

  2. Zhangjiang Fudan International Innovation Centre, Human Phenome Institute, Fudan University, Shanghai, China

    Hui Zhang, Meng-Zhen Sun, Jiu-Cun Wang & Xiao-Feng Wang

  3. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 201203, China

    Xiao-Feng Wang

  4. Rugao People’s Hospital, Rugao, Jiangsu, China

    Yin-Sheng Zhu, Guo-Ping Shi & Zheng-Dong Wang

  5. Department of Epidemiology, Human Phenome Institute, Fudan University, Shanghai, China

    Xiao-Feng Wang

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  1. Na Zhang
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Contributions

NZ, J-CW, and X-FW designed the research; NZ, HZ, M-ZS, Y-SZ, G-PS and WZ-D conducted the research; NZ and HZ analyzed the data and performed the tactical analyses; NZ and X-FW wrote the paper; NZ and X-FW had primary responsibility for the final content; and all the authors read and approved the final manuscript.

Corresponding authors

Correspondence to Jiu-Cun Wang or Xiao-Feng Wang.

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Conflict of interest

The authors declare that they have no relevant financial interests.

Ethical approval

This study was approved by the Human Ethics Committee of the School of Life Sciences of Fudan University. Informed consent was obtained from each participant.

Informed consent

Written informed consent was obtained from all participants or their guardians prior to the study.

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Zhang, N., Zhang, H., Sun, MZ. et al. Intrinsic capacity and 5-year late-life functional ability trajectories of Chinese older population using ICOPE tool: the Rugao Longevity and Ageing Study. Aging Clin Exp Res 35, 2061–2068 (2023). https://doi.org/10.1007/s40520-023-02489-6

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  • DOI: https://doi.org/10.1007/s40520-023-02489-6

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