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Fish oil administration combined with resistance exercise training improves strength, resting metabolic rate, and inflammation in older adults

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Abstract

Background

While fish oil (FO) has attracted great attention due to their health-enhancing properties, its potential to enhance benefits from resistance exercise training (RET) has not been fully elucidated yet.

Aims

The aim of this study was to investigate effects of FO administration during 12 weeks of programmed RET on muscular strength, resting metabolic rate (RMR), and systemic inflammation in healthy older adults.

Methods

Twenty-eight healthy older adults were randomly assigned to three experimental groups: sedentary control (CON), resistance exercise training (RET), or RET combined with FO (RET-FO). A one-repetition (1RM) of maximum muscle strength, RMR, substrate oxidation, and blood inflammatory biomarkers were assessed before and after the intervention. Statistical significance was set at p ≤ 0.05.

Results

1RM muscle strength was significantly increased in RET and RET-FO while substantially decreased in CON. RMR greatly increased in RET and RET-FO with no change in CON. RET-FO exhibited significantly increased fatty acid oxidation, but no change was found in CON and RET. Systemic interleukin 6 (IL-6) and C-reactive protein (CRP) were significantly decreased from baseline in RET-FO while no change was observed in CON and RET.

Conclusion

Our data indicate chronic RET reversed aging-induced loss of muscle strength and improved RMR, while FO administration combined with RET appears to enhance fat metabolism and mildly reduce some indicators of systemic inflammation.

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Acknowledgements

Appreciation is extended to the undergraduate assistants in Biochemistry and Molecular Exercise Physiology Lab in New Mexico State University for exercise training and data collection; Rebecca Mehlin, Gilbert Sigala, Joshua Krause, Lexie Fitch, and Josi Gabaldon. This research was supported by New Mexico State University.

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Authors and Affiliations

  1. Department of Kinesiology, New Mexico State University, Las Cruces, NM, 88003, USA

    Sang-Rok Lee & Dean Directo

  2. Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Andy V. Khamoui

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  1. Sang-Rok Lee
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Contributions

SL conceived and designed research and conducted experiments. SL and DD analyzed data. SL wrote manuscript. DD and AK reviewed and edited manuscript. All authors read and approved the manuscript.

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Correspondence to Sang-Rok Lee.

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The authors declare no conflicts of interest associated with this manuscript.

Ethical approval

This study was approved by the New Mexico State University Institutional Review Board for Human Subjects. All the research procedures has been conducted in accordance with the Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all participants prior to being admitted to the study.

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Lee, SR., Directo, D. & Khamoui, A.V. Fish oil administration combined with resistance exercise training improves strength, resting metabolic rate, and inflammation in older adults. Aging Clin Exp Res 34, 3073–3081 (2022). https://doi.org/10.1007/s40520-022-02250-5

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  • DOI: https://doi.org/10.1007/s40520-022-02250-5

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