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The influence of hypertension management on frailty prevention among older persons aged 65 and over: a systematic review

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Abstract

Background

Frailty and hypertension are interrelated, but it remains unclear whether this relationship is modified by antihypertensive drugs.

Methods and results

A systematic review of PubMed and Web of Science databases was performed to review the influence of hypertension management on preventing the occurrence or progression of frailty in older people aged 65 and over. Studies providing information on this association regardless of the study setting, or definition of hypertension and frailty were included. Among the initial 2298 articles identified, 7 were included in the review. Three observational studies assessed the association between frailty and hypertension. Two of them reported no relationship between Aldosterone Antagonists use and frailty prevention. No relationship between BP and incidence frailty after adjustment for hypertension treatment was observed in two other articles. An indirect relationship was reported in the RCTs included. Higher AT11RaAb levels (control group), can lead to a generalized weakness/frailty risk shown by a decrease in grip strength (r = –0.57, p < 0.005) and walking speed (r = – 0.47, p < 0.005). No significant differences between int-hypertensive intervention and control were observed in frailty status after a 12-weeks follow-up after applying three different frailty measurement tools in the other RCT.

Conclusions

Based on the results of this systematic review we conclude that BP and frailty occur together but whether the treatment with anti-hypertensive drugs modifies this relationship remains unclear and needs to be further investigated.

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Acknowledgements

Members of the Gerontopole Brussels Study group:

Ivan Bautmans (FRIA, VUB) ivan.bautmans@vub.be;

Dominque Verté (Belgian Ageing Studies BAST, VUB) dominique.verte@vub.be;

Ingo Beyer (Geriatric Medicine department, UZ Brussel) ingo.beyer@uzbrussel.be;

Mirko Petrovic (ReFrail, UGent) mirko.petrovic@ugent.be;

Nico De Witte (Belgian Ageing Studies BAST, VUB) nico.de.witte@vub.be;

Tinie Kardol (Leerstoel Bevordering Active Ageing, VUB) mjmkardol@hotmail.com;

Gina Rossi (Clinical and Lifespan Psychology KLEP, VUB) grossi@vub.be;

Peter Clarys (Physical Activity and Nutrition PANU, VUB) pclarys@vub.be;

Aldo Scafoglieri (Experimental Anatomy EXAN, VUB) aldo.scafoglieri@vub.be;

Erik Cattrysse (Experimental Anatomy EXAN, VUB) ecattrys@vub.be;

Paul de Hert (Fundamental Rights and Constitutionalism Research group FRC, VUB) paul.de.hert@vub.be;

Bart Jansen (Department of Electronics and Informatics ETRO, VUB) bart.jansen@vub.be

Funding

This study was funded by an “Interdisciplinary Research Program” grant from the research council of the Vrije Universiteit Brussel (VUB).

Author information

Author notes

  1. Orgesa Qipoa and Aziz Debain are joint first author. Orgesa Qipoa and Aziz Debain have contributed equally to this work.

Authors and Affiliations

  1. Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium

    Orgesa Qipo, Aziz Debain & Ivan Bautmans

  2. Department of Geriatrics, Universitair Ziekenhuis Brussels (UZBrussels), Laarbeeklaan 101, B-1090, Brussels, Belgium

    Ivan Bautmans

Authors
  1. Orgesa Qipo
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  2. Aziz Debain
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  3. Ivan Bautmans
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Consortia

on behalf of the Gerontopole Brussels Study Group

  • Ivan Bautmans
  • , Dominque Verté
  • , Ingo Beyer
  • , Mirko Petrovic
  • , Nico De Witte
  • , Tinie Kardol
  • , Gina Rossi
  • , Peter Clarys
  • , Aldo Scafoglieri
  • , Erik Cattrysse
  • , Paul de Hert
  •  & Bart Jansen

Contributions

Ivan BAUTMANS conceived the review idea, acquired the funding and contribute to the review protocol, selection of the articles, interpretation of the data, and writing and editing of the manuscript. Orgesa QIPO and Aziz DEBAIN performed the literature search, article selection, quality assessment, data extraction and prepared the original draft of the manuscript.

Corresponding author

Correspondence to Ivan Bautmans.

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Qipo, O., Debain, A., Bautmans, I. et al. The influence of hypertension management on frailty prevention among older persons aged 65 and over: a systematic review. Aging Clin Exp Res 34, 2645–2657 (2022). https://doi.org/10.1007/s40520-022-02247-0

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  • DOI: https://doi.org/10.1007/s40520-022-02247-0

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