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Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease

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Abstract

This study explored the potential relationship between levels of high-sensitivity C-reactive protein (hs-CRP) in plasma and freezing of gait (FOG) in Parkinson's disease (PD) in China. A total of 72 healthy subjects, 62 PD patients with FOG, and 83 PD patients without FOG from our center were enrolled in this prospective study. Patients with FOG showed significantly higher hs-CRP levels than controls, but patients without FOG did not. Binary logistic regression analysis identified levels of hs-CRP in plasma to be an independent risk factor for FOG among the patients in our cohort (OR 6.371, 95% CI 2.589–15.678, p < 0.001). In fact, a cut-off level of 0.935 mg/L distinguished patients with or without FOG [area under the ROC curve (AUC) = 0.908, sensitivity 87.1%, specificity 89.2%]. Our study suggests that high levels of hs-CRP in plasma are associated with the occurrence of FOG in PD. The pooled data combined with a previous study carried out in Spain also indicate a positive association between plasma hs-CRP levels and FOG in PD. However, more research is still needed to verify the plasma hs-CRP as a potential biomarker of FOG.

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Acknowledgements

We thank the patients with Parkinson's disease and the healthy control group for their participation in our study.

Funding

This research was supported by Yunnan Province Clinical Research Center for Neurological Disease(202002AA100204), National Natural Science Foundation of China [grant numbers: 81960242], Applied Basic Research Foundation of Yunnan Province[grant numbers: 202101AY070001-115], Yunnan Province Clinical Research Center for Geriatric Disease [grant number: 202102AA310069].

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Author notes

  1. Jie Liu, Weifang Yin and Chuanbin Zhou contributed equally to this work.

Authors and Affiliations

  1. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People’s Republic of China

    Jie Liu, Weifang Yin, Chuanbin Zhou, Yangfan Zhu, Meijuan Gu, Bin Liu, Hui Ren & Xinglong Yang

  2. Yunnan Province Clinical Research Center for Gerontology, Kunming, 650032, Yunnan, People’s Republic of China

    Yangfan Zhu, Meijuan Gu, Bin Liu, Hui Ren & Xinglong Yang

  3. Department of Neurology, Zhenkang County People’s Hospital, Lincang, 677704, Yunnan, People’s Republic of China

    Jie Liu

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  1. Jie Liu
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Contributions

JL contributed to the acquisition of the data, statistical analysis, and interpretation of the data, and drafted the manuscript. XY contributed to the study concept and design, acquisition of the data, statistical analysis, and critical revision of the manuscript for important intellectual content. WY, CZ, YZ, MG, BL and HR contributed to the acquisition of the data and clinical assessment.

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Correspondence to Xinglong Yang.

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All procedures performed in studies involving human participants were in accordance with the ethical standards declaration and its later amendments or comparable ethical standards.

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Written informed consent was obtained from all patients and their families for their anonymized clinical data to be published for research purposes.

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Liu, J., Yin, W., Zhou, C. et al. Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease. Aging Clin Exp Res 34, 1865–1872 (2022). https://doi.org/10.1007/s40520-022-02134-8

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