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Mitochondrial communication in the context of aging

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Abstract

Mitochondria constantly contribute to the cell homeostasis and this, during the lifespan of a cell, takes its toll. Indeed, the functional decline of mitochondria appears correlated to the aging of the cell. The initial idea was that excessive production of reactive oxygen species (ROS) by functionally compromised mitochondria was the causal link between the decline of the organelle functions and cellular aging. However, in recent years accumulating evidence suggests that the contribution of mitochondria to cellular aging goes beyond ROS production. In this short review, we discuss how intracellular signalling, specifically the cAMP-signalling cascade, is involved in the regulation of mitochondrial functions and potentially in the processes that link mitochondrial status to cellular aging.

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Funding

This work was supported by the National Research Council of Italy (CNR), Research Project “Aging: molecular and technological innovations for improving the health of the elderly population” (Prot. MIUR 2867 25.11.2011).

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Authors and Affiliations

  1. Department of Molecular Medicine, University of Pavia, 27100, Pavia, Italy

    Konstantinos Lefkimmiatis

  2. Veneto Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129, Padova, Italy

    Konstantinos Lefkimmiatis, Francesca Grisan, Liliana F. Iannucci, Nicoletta C. Surdo, Tullio Pozzan & Giulietta Di Benedetto

  3. Neuroscience Institute, National Research Council of Italy (CNR), 35121, Padova, Italy

    Francesca Grisan, Tullio Pozzan & Giulietta Di Benedetto

  4. Department of Biomedical Sciences, University of Padova, 35121, Padova, Italy

    Tullio Pozzan

  5. Department of Biology, University of Padova, 35121, Padova, Italy

    Liliana F. Iannucci

Authors
  1. Konstantinos Lefkimmiatis
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  2. Francesca Grisan
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  3. Liliana F. Iannucci
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  4. Nicoletta C. Surdo
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  5. Tullio Pozzan
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  6. Giulietta Di Benedetto
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Corresponding authors

Correspondence to Tullio Pozzan or Giulietta Di Benedetto.

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In the original work by the authors all applicable international, national, and/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.

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Lefkimmiatis, K., Grisan, F., Iannucci, L.F. et al. Mitochondrial communication in the context of aging. Aging Clin Exp Res 33, 1367–1370 (2021). https://doi.org/10.1007/s40520-019-01451-9

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  • DOI: https://doi.org/10.1007/s40520-019-01451-9

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