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Possible association between circulating CTRP3 and knee osteoarthritis in postmenopausal women

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Abstract

Background

Osteoarthritis (OA) is considered as one of the most common cause of chronic pain and functional disabilities in the elderly.

Aim

To examine serum levels of complement-C1q TNF-related protein 3 (CTRP3) in postmenopausal women with knee OA.

Methods

A population-based cross-sectional study was performed in women who complained of chronic knee pain. All subjects were followed by clinical and weight-bearing bilateral anteroposterior radiographical examinations. The Kellgren and Lawrence (K&L) score was used for knee OA classification. Two groups of postmenopausal women were chosen to investigate CTRP3 as an OA marker who had the K&L score ≥ 3 as a case group and K&L ≤ 1 as a control group. Serum levels of CTRP3 were measured in two groups.

Results

According to K&L classification, 36 subjects with knee OA and 54 age-matched without or mild OA were selected. After adjusting the obtained data for taking NSAID drugs, the concentration of Ln CTRP3 in serum of patients with OA was lower compared to control group [mean ± SE, (0.39 ± 0.05 ng/ml vs. 0.48 ± 0.03 ng/ml, respectively, p = 0.04)].

Discussion

There is a possible role for CTRP3 as an anti-inflammatory mediator in knee OA in postmenopausal women.

Conclusions

Our results indicate an association between CTRP3 and knee OA. However, a much more robust study is required to draw that circulating CTRP3 could be a clinical marker for osteoarthritis.

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Acknowledgements

We thank Neighborhood (Mahalle)’s Houses, Tehran, Iran for allowing us to conduct this study.

Funding

The authors received no financial support.

Author information

Authors and Affiliations

  1. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute of Tehran University of Medical Sciences, Tehran, Iran

    Zhila Maghbooli & Seyed Ali Asghar Malekhosseini

  2. MS Research Center, Neuroscience Institute of Tehran University of Medical Sciences, Tehran, Iran

    Zhila Maghbooli

  3. Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, Boston, MA, USA

    Arash Hossein-nezhad

  4. Endocrinology and Metabolism Clinical Sciences Center, Endocrinology and Metabolism Clinical Sciences Institute of Tehran University of Medical Sciences, Tehran, Iran

    Ghazal Khoshechin & Elham Adabi

  5. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Gelare Niketeghad & Shahrokh Moradi

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  1. Zhila Maghbooli
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Correspondence to Zhila Maghbooli or Arash Hossein-nezhad.

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The authors announce that there was no conflict of interests in relation with this study.

Statement of human and animal rights

The study was approved by the Ethics Committee of the EMRI (IR.Tums.EMRI.REC.1395.00130).

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A written informed consent was obtained from all participants

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Maghbooli, Z., Hossein-nezhad, A., Khoshechin, G. et al. Possible association between circulating CTRP3 and knee osteoarthritis in postmenopausal women. Aging Clin Exp Res 31, 927–934 (2019). https://doi.org/10.1007/s40520-018-1035-5

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  • DOI: https://doi.org/10.1007/s40520-018-1035-5

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