Skip to main content

Advertisement

Log in

Arterial stiffness and left ventricular performance in elderly patients with persistent atrial fibrillation

  • Short Communication
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Background

The prevalence of atrial fibrillation (AF) and arterial stiffness (AS) increases with age.

Aims

To evaluate if AS is correlated to longitudinal strain (LS), a marker of left ventricular (LV) function, in elderly AF patients with preserved ejection fraction (EF) undergoing external cardioversion.

Methods

AS was measured using the cardio-ankle vascular index (CAVI), LS was calculated from echocardiographic data of three consecutive cardiac cycles.

Results

We enrolled 38 patients (age 76 ± 8 years; men 60.5%; EF 65 ± 7%). LS and CAVI were, respectively, − 17.7 ± 3.7% and 9.7 ± 1.3. Multivariate analysis showed that LV performance was inversely related to height (p < 0.001) and to the presence of AF-related symptoms (p = 0.008). LS grew with increasing values of CAVI (p = 0.038).

Conclusions

In elderly AF patients with preserved systolic function, LV performance is directly associated with AS. This link could influence atrium remodeling and the incidence of arrhythmia relapse.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Kirchhof P, Benussi S, Kotecha D et al (2016) 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 37:2893–2962. https://doi.org/10.1093/eurheartj/ehw210

    Article  Google Scholar 

  2. Fumagalli S, Tarantini F, Guarducci L et al (2010) Atrial fibrillation is a possible marker of frailty in hospitalized patients: results of the GIFA study. Aging Clin Exp Res 22:129–133. https://doi.org/10.3275/6592

    Article  CAS  PubMed  Google Scholar 

  3. Cavalcante JL, Lima JA, Redheuil A et al (2011) Aortic stiffness: current understanding and future directions. J Am Coll Cardiol 57:1511–1522. https://doi.org/10.1016/j.jacc.2010.12.017

    Article  PubMed  Google Scholar 

  4. Januzzi JL Jr, Chandrashekhar Y (2017) Strain echocardiography: the new gold standard for imaging ventricular function? J Am Coll Cardiol 70:955–957. https://doi.org/10.1016/j.jacc.2017.07.717

    Article  PubMed  Google Scholar 

  5. Hunt SA, Abraham WT, Chin MH et al (2009) 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol 53:e1–e90. https://doi.org/10.1016/j.jacc.2008.11.013

    Article  PubMed  Google Scholar 

  6. Fumagalli S, Boni N, Padeletti M et al (2006) Determinants of thoracic electrical impedance in external electrical cardioversion of atrial fibrillation. Am J Cardiol 98:82–87. https://doi.org/10.1016/j.amjcard.2006.01.065

    Article  PubMed  Google Scholar 

  7. Fumagalli S, Gabbai D, Nreu B et al (2014) Age, left atrial dimension and arterial stiffness after external cardioversion of atrial fibrillation. A vascular component in arrhythmia maintenance? Results from a preliminary study. Aging Clin Exp Res 26:327–330. https://doi.org/10.1007/s40520-013-0173-z

    Article  PubMed  Google Scholar 

  8. Shirai K, Hiruta N, Song M et al (2011) Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives. J Atheroscler Thromb 18:924–938

    Article  Google Scholar 

  9. Gorcsan J III, Tanaka H (2011) Echocardiographic assessment of myocardial strain. J Am Coll Cardiol 58:1401–1413. https://doi.org/10.1016/j.jacc.2011.06.038

    Article  PubMed  Google Scholar 

  10. Kuznetsova T, Herbots L, Richart T et al (2008) Left ventricular strain and strain rate in a general population. Eur Heart J 29:2014–2023. https://doi.org/10.1093/eurheartj/ehn280

    Article  PubMed  Google Scholar 

  11. Reckefuss N, Butz T, Horstkotte D et al (2011) Evaluation of longitudinal and radial left ventricular function by two-dimensional speckle-tracking echocardiography in a large cohort of normal probands. Int J Cardiovasc Imaging 27:515–526. https://doi.org/10.1007/s10554-010-9716-y

    Article  PubMed  Google Scholar 

  12. Ye Z, Coutinho T, Pellikka PA et al (2015) Associations of alterations in pulsatile arterial load with left ventricular longitudinal strain. Am J Hypertens 28:1325–1331. https://doi.org/10.1093/ajh/hpv039

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bell V, McCabe EL, Larson MG et al (2017) Relations between aortic stiffness and left ventricular mechanical function in the community. J Am Heart Assoc. https://doi.org/10.1161/JAHA.116.004903

    Article  PubMed  PubMed Central  Google Scholar 

  14. Fumagalli S, Giannini I, Pupo S et al (2016) Atrial fibrillation after electrical cardioversion in elderly patients: a role for arterial stiffness? Results from a preliminary study. Aging Clin Exp Res 28:1273–1277. https://doi.org/10.1007/s40520-016-0620-8

    Article  PubMed  PubMed Central  Google Scholar 

  15. Mitchell GF, Vasan RS, Keyes MJ et al (2007) Pulse pressure and risk of new-onset atrial fibrillation. JAMA 297:709–715. https://doi.org/10.1001/jama.297.7.709

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Stefano Pedri, EE, and Angelo Sortezza, EE, by ESAOTE SpA (Italy), and Mrs. Yumiko Kato, by Fukuda Denshi (Japan), for their unconditioned help to the research project.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefano Fumagalli.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Human rights

All procedures were performed in accordance with the principles of the Declaration of Helsinki and approved by the appropriate institutional review committee.

Informed consent

All subjects gave their informed consent to participate in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fumagalli, S., Migliorini, M., Pupo, S. et al. Arterial stiffness and left ventricular performance in elderly patients with persistent atrial fibrillation. Aging Clin Exp Res 30, 1403–1408 (2018). https://doi.org/10.1007/s40520-018-0935-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40520-018-0935-8

Keywords

Navigation