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Metabolic syndrome and disability in Chinese nonagenarians and centenarians

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Abstract

Background

Little is known about the relationship between metabolic syndrome (MetS) and disability in the oldest old.

Aims

To investigate the possible association between MetS and disability among community-dwelling older adults aged ≥ 90 years.

Methods

This was a secondary analysis of a cross-sectional study. MetS was defined by the International Diabetes Federation Criteria. Activities of daily living (ADL) and instrumental activities of daily living (IADL) disabilities were evaluated using the physical self-maintenance scale and the Lawton–Brody IADL scale, respectively.

Results

We included 725 participants (mean age: 93.8 ± 3.1 years). The prevalence of MetS was 13.0% in women and 9.8% in men, respectively. In women, ADL and IADL disabilities were more prevalent in the MetS group compared with the non-MetS group (ADL: 43.1 vs. 30.6%, p = 0.044; IADL: 73.8 vs. 59.8%, p = 0.030). After adjusting for relevant confounders, participants with MetS was associated with an increased risk of either ADL (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.22–3.45) or IADL disability (OR 2.12, 95% CI 1.31–4.78) compared with those without MetS. In men, similar results were found with respect to the prevalence of ADL or IADL disability and the adjusted ORs, but the results were not statistically significant.

Conclusion

MetS is associated with an increased risk of either ADL or IADL disability in a study population of long-lived adults, especially in women.

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Acknowledgements

The authors are grateful to the staff of the Department of Geriatrics, Dujiangyan Hospital; and all participants (as well as their legal proxies) for their great contributions.

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Authors and Affiliations

  1. The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China

    Ming Yang & Birong Dong

  2. West China School of Medicine, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China

    Hanyue Xu

  3. Outpatient Department, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China

    Ling Yang

  4. The Center of Rehabilitation, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan, China

    Jiaojiao Jiang

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  1. Ming Yang
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Corresponding author

Correspondence to Ming Yang.

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Conflict of interest

None of the authors has any conflict of interest related to this work.

Human and animal rights

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any study with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all the participants in this study or their legal proxies.

Funding

The PLAD study was supported by Discipline Construction Foundation of Sichuan University, grants from the project of Science and Technology Bureau of Sichuan, Province (2006Z09-006-4), and Construction Fund for Subjects of West China, Hospital of Sichuan University (XK05001). Additional funding for this secondary analysis came from the Sichuan Provincial Science and Technology Department (2016JY0058). The sponsors had no role in the design, methods, data collection, analysis, and preparation of this work.

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Yang, M., Xu, H., Yang, L. et al. Metabolic syndrome and disability in Chinese nonagenarians and centenarians. Aging Clin Exp Res 30, 943–949 (2018). https://doi.org/10.1007/s40520-017-0877-6

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  • DOI: https://doi.org/10.1007/s40520-017-0877-6

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