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The Dental Drug Delivery System for Prevention of Dental Caries

  • Cariology (J Tagami, Section Editor)
  • Published:
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Abstract

A new therapy for the management of early caries lesions and caries prevention was established for clinical use. This therapy was named the Dental Drug Delivery System (3DS), and its effectiveness was confirmed by clinical evaluations. The 3DS method involves the application of either antimicrobial drugs or fluoride gels, with individual trays at the chair-side and also for home care program. By using the individual trays, only the cariogenic bacteria “Streptococcus mutans” that adheres to the tooth surface is controlled without changing the core composition of oral microflora. Therefore, we recommend the use of this method in dental clinics for caries management. The 3DS method should be used especially by pregnant women and mothers raising small children because children most often receive the S. mutans from their mothers via saliva. Patients with dental implants also should be treated by 3DS in order to prevent peri-implantitis. Perioperative patients and bed-ridden people who find it physically challenging to take care of their teeth would also benefit from the 3DS. Patients with severe halitosis are also candidates for 3DS treatment. The scientific rationale of 3DS and the clinical procedure involved are introduced in this article.

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References

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  1. Newbrun E. Cariology. Boltimore: The Williams & Wilkins Company; 1978. p. 259.

    Google Scholar 

  2. Murata T, Hanada N (submitted) Contribution of chloride channel permease to fluoride resistance in Streptococcus mutans

  3. Catalanotto FA, Shklair IL, Keene HJ. Prevalence and localization of Streptococcus mutans in infants and children. J Am Dent Assoc. 1975;91:606–9.

    Article  CAS  PubMed  Google Scholar 

  4. Caufield PW, Cutter GR, Dasanayake AP. Initial acquisition of mutans streptococci by infants: evidence for a discrete window of infectivity. J Dent Res. 1993;72:37–45.

    Article  CAS  PubMed  Google Scholar 

  5. Takeuchi H, Fukushima K, Senpuku H, Nomura Y, Kaneko N, Yano A, et al. Clinical study of mutans streptococci using 3DS and monoclonal antibodies. Jpn J Infect Dis. 2000;54:34–6.

    Google Scholar 

  6. Tamaki Y, Nomura Y, Takeuchi H, Ida H, Arakawa H, Tsurumoto A, et al. Study of the clinical usefulness of a dental drug system for selective reduction of mutans streptococci using a case series. J Oral Sci. 2006;48:111–6.

    Article  PubMed  Google Scholar 

  7. Tamaki Y, Nomura Y, Katsumura S, Okada A, Yamada H, Tsuge S, et al. Construction of a dental caries prediction model by data mining. J Oral Sci. 2009;51:61–8.

    Article  PubMed  Google Scholar 

  8. Takeuchi H, Senpuku H, Matin K, Kaneko N, Yusa N, Yoshikawa E, et al. New dental drug delivery system for removing mutans streptococci from the oral cavity effect on oral microbial flora. Jpn J Infect Dis. 2000;53:211–2.

    CAS  PubMed  Google Scholar 

  9. Nomura Y, Takeuchi H, Kaneko N, Matin K, Iguchi R, Toyoshima Y, et al. Feasibility of eradication of mutans streptococci from oral cavities. J Oral Sci. 2004;46:179–83.

    Article  PubMed  Google Scholar 

  10. Katsumura S, Nomura Y, Nishikawara F, Nishikawa T, Kumagai T, Sato K, et al. Pilot study of the effect of a new dental drug delivery system for removal of mutans streptococci infection in adults. Asian Pac J Dent. 2013;13:11–8. Randomized controlled trials (RCT) are known as the best method to prove causality. This paper is the first report on RCT of 3DS method.

    CAS  Google Scholar 

  11. Hildebrandt GH. Effect of repeated treatment with sustained-release chlorhexidine mouth guards on salivary levels of mutans streptococci. Caries Res. 1996;30:445–53.

    Article  CAS  PubMed  Google Scholar 

  12. Ostela I, Karhuvaara L, Tenovuo J. Comparative antibacterial effects of chlorhexidine and stannous fluoride-amine fluoride containing dental gels against salivary mutans streptococci. Scand J Dent Res. 1991;99:378–83.

    CAS  PubMed  Google Scholar 

  13. Hildebrandt GH, Pape Jr HR, Syed SA, Gregory WA, Friedman M. Effect of slow-release chlorhexidine mouthguards on the levels of selected salivary bacteria. Caries Res. 1992;26:268–74.

    Article  CAS  PubMed  Google Scholar 

  14. Achong RA, Briskie DM, Hildebrandt GH, Feigal RJ, Loesche WJ. Effect of chlorhexidine varnish mouthguards on the levels of selected oral microorganisms in pediatric patients. Pediatr Dent. 1999;21:169–75.

    CAS  PubMed  Google Scholar 

  15. Emilson CG, Gisselsson H, Birkhed D. Recolonisation pattern of mutans streptococci after suppression by three different modes of chlorhexidine gel application. Eur J Oral Sci. 1999;107:170–5.

    Article  CAS  PubMed  Google Scholar 

  16. Dahlen G. Effect of antimicrobial mouthrinses on salivary microflora in healthy subjects. Scand J Dent Res. 1984;92:38–42.

    CAS  PubMed  Google Scholar 

  17. Ullsfoss BN, Ogaard B, Arends J. Effect of a combined chlorhexidine and NaF mouthrinse an in vivo human caries model. Scand J Dent Res. 1994;102:109–12.

    CAS  PubMed  Google Scholar 

  18. Clark DC, Guest JL. The effectiveness of three different strengths of chlorhexidine mouthrinse. J Can Dent Assoc. 1994;60:711–4.

    CAS  PubMed  Google Scholar 

  19. Schaeken MJ, van der Hoeven JS, Hendriks JC. Effects of varnishes containing chlorhexidine on the human dental plaque flora. J Dent Res. 1989;68:1786–9.

    Article  CAS  PubMed  Google Scholar 

  20. Schaeken MJ, De Haan P. Effects of sustained-release chlorhexidine acetate on the human dental plaque flora. J Dent Res. 1989;68:119–23.

    Article  CAS  PubMed  Google Scholar 

  21. Sandham HJ, Brown J, Chan KH, Phillips HI, Burgess RC, Stokl AJ. Clinical trial in adults of an antimicrobial varnish for study. Scand J Dent Res. 1994;102:109–12.

    Google Scholar 

  22. Baker JL, Sudarsan N, Weinberg Z, et al. Widespread genetic switches and toxicity resistance proteins for fluoride. Science. 2012;335:233–5. Fluoride resistance of S. mutans hypothesized that fluoride riboswitch or another type of fluoride sensor system can exclude the fluoride ion from the cell membrane, thereby developing resistance. This paper is the first report on an existence of fluoride riboswitch.

  23. Mariotti A, Hefti F. Drug for the control of supragingival plaque. In: Craig CR, Stitzel RE, editors. Modern pharmacology with clinical applications. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 504.

    Google Scholar 

  24. Kumar PS, Mason MR, Brooker MR, O’Brien K. Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants. J Clin Periodontol. 2012;39:425–33. Peri-implantitis biofilms were associated with higher level of Streptococcus mutans than healthy teeth and healthy implant biofilms. Biofilms with higher level of Streptococcus mutans could be changed by 3DS method.

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Number 15K15777.

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Correspondence to Nobuhiro Hanada.

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Nobuhiro Hanada reports grants from the Japanese government during the conduct of study.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Cariology

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Hanada, N. The Dental Drug Delivery System for Prevention of Dental Caries. Curr Oral Health Rep 3, 124–128 (2016). https://doi.org/10.1007/s40496-016-0088-9

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  • DOI: https://doi.org/10.1007/s40496-016-0088-9

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