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Exploration of the Growing Therapeutic Potentials of Quercetin in Ovarian Cancer Management

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Abstract

Purpose of Review

This review aims to offer a comprehensive insight and a recent update into the etiology and pathophysiology of ovarian cancer, a recent update on the usage of quercetin for ovarian cancer management.

Recent Findings

Over the last few decades, an alarming increase in global rates of ovarian cancer has been observed, resulting in increased pressure on the healthcare system. In order to effectively address the situation, there is a need to explore alternatives to currently dominant treatment regimes. The usage of phytoconstituents, such as polyphenols as anti-cancer agents, has emerged as a promising alternative. Quercetin, a widely distributed dietary flavonol, possesses potent antioxidant, anti-inflammatory, and cytoprotective properties, and has been used in the amelioration of a variety of metabolic disorders. In addition to effectively managing various types of cancer, it has been seen to pose lowered side effects and improve the overall quality of life of patients.

Summary

Literature search of quercetin showed remarkable properties like antioxidant, anti-cancer, anti-apoptotic, anti-inflammatory, and bioavailability-enhancing abilities that fit its appropriate use in pathological conditions. However, being a product of natural origin, bioavailability and optimal delivery may prove to be challenging to achieving the desired therapeutic efficacy. This review, in turn, furthers our understanding of the applications of quercetin in cancer management and the identification of challenges and future perspectives, to enable the maximization of therapeutic efficacy.

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Acknowledgements

The authors are thankful to Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS for providing the infrastructural facilities and support.

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Authors and Affiliations

  1. Department of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, Vile Parle (West), Mumbai, 400 056, Maharashtra, India

    Dhruv Sanjay Gupta, Vaishnavi Gadi & Ginpreet Kaur

  2. Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, MB Road, New Delhi, 110017, India

    Madhu Gupta

  3. University Center for Research & Development (UCRD), Biotechnology Engineering & Food Technology, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India

    Ajay Kumar

  4. Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133 207, India

    Hardeep Singh Tuli

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  1. Dhruv Sanjay Gupta
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  3. Ginpreet Kaur
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  4. Madhu Gupta
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Contributions

GK visualized the presented idea, contributed to manuscript writing and supervised the project. DSG, VG and AK contributed to literature searches and preparing the manuscript draft. AK, MG and HST revised and approved the manuscript.

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Correspondence to Ginpreet Kaur.

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Gupta, D.S., Gadi, V., Kaur, G. et al. Exploration of the Growing Therapeutic Potentials of Quercetin in Ovarian Cancer Management. Curr. Pharmacol. Rep. 9, 455–467 (2023). https://doi.org/10.1007/s40495-023-00343-x

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