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Traditional Chinese Medicine in Multiple Sclerosis: Theory and Practice

  • Neuropharmacology (R Pi, Section Editor)
  • Published:
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Abstract

Purpose of review

Multiple sclerosis (MS) is a disease with complex etiology and pathophysiology. Approved drugs for MS treatment are only partly effective, and some of them show obvious side effects and resistance. In this review, we will discuss the philosophy and advantages of traditional Chinese medicine (TCM) as a complementary and alternative therapy for MS treatment. The purpose of this review is to provide novel insights and directions for MS management.

Recent Findings

TCM is an empirical medical system which has established its own unique method of diagnosis and therapy for over thousands of years. The concept of holism and yin-yang balance are its core theories. From TCM perspective, syndrome differentiation, deficiency tonification, stasis removal, and detoxication are the four main principles of MS treatment. Clinical trials have shown that TCM is effective to alleviate symptoms, prevent recurrence, and delay disease progression in MS patients. Experimental evidences also have confirmed the effect of TCM in experimental autoimmune encephalomyelitis (EAE), which is in the multitarget and multicomponent pattern. TCM maximize therapeutic efficacy by facilitating synergistic actions, exhibiting various biological activities including anti-inflammatory, anti-oxidative, immune-regulatory, and neuro-protective effects in MS and EAE. Treatment with TCM alone or combined with western medicine can greatly improve the body’s resistance and reduce side effects of the treatment.

Summary

Integrating TCM with Western medicine have great promise for inspiring new ideas and therapies for prevention and treatment of MS. The appropriate combination can improve efficacy, reduce toxicity, and make the best benefits in MS patients.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance

  1. Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15:545–58. https://doi.org/10.1038/nri3871.

    Article  CAS  PubMed  Google Scholar 

  2. Auricchio F, Scavone C, Cimmaruta D, Di Mauro G, Capuano A, Sportiello L, et al. Drugs approved for the treatment of multiple sclerosis: review of their safety profile. Expert Opin Drug Saf. 2017;16(12):1359–71. https://doi.org/10.1080/14740338.2017.1388371.

    Article  CAS  PubMed  Google Scholar 

  3. Cummings J. Disease modification and neuroprotection in neurodegenerative disorders. Transl Neurodegener. 2017;26(6):25. https://doi.org/10.1186/s40035-017-0096-2.

    Article  CAS  Google Scholar 

  4. Hager S, Dai JZ, Fischer V, Lüthke F, Staudinger A. East meets west: synergy through diversity. Forsch Komplementmed. 2016;23(suppl2):3–7. https://doi.org/10.1159/000444766.

    Article  PubMed  Google Scholar 

  5. Mitsikostas DD, Goodin DS. Comparing the efficacy of disease-modifying therapies in multiple sclerosis. Mult Scler Relat Disord. 2017;18:109–16. https://doi.org/10.1016/j.msard.2017.08.003.

    Article  PubMed  Google Scholar 

  6. Kim S, Chang L, Weinstock-Guttman B, Gandhi S, Jakimovski D, Carl E, et al. Complementary and alternative medicine usage by multiple sclerosis patients: results from a prospective clinical study. J Altern Complement Med. 2018;24:596–602. https://doi.org/10.1089/acm.2017.0268.

    Article  PubMed  Google Scholar 

  7. Wang LX. On treatment of multiple sclerosis from hidden pathogen theory. Journal of Nanjing University of TCM. 2014;30(6):507–10. https://doi.org/10.14148/j.issn.1672-0482.2014.06.003.

    Article  CAS  Google Scholar 

  8. Wang YQ, Wang L. Discussion on the relationship between multiple sclerosis and viscera channels from collateral disease theory. China J Tradit Chin Med Pharm. 2017;32(8):3384–8. ISSN: 1673-1727

    Google Scholar 

  9. •• Neijing H. Yellow Emperor’s Canon of Medicine. Translation by Luo Xiwen at the Chinese Academy of Social Sciences, Beijing, China; 2009. ISBN 978-7-80231-634-8. This book is a classic of internal medicine written during the period 770-221 BC, is still consider the most important pillar of TCM because it established the fundamental TCM theories that remain highly relevant and inspire new therapeutic ideas today.

  10. Scheid V. Hilism, Chinese medicine and systems ideologies: rewriting the past to imagine the future. East Asian Sci Technol Soc. 2014;8(1):107–39. https://doi.org/10.1215/18752160-2407180.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ji YX, Zhou FS. Micro-holism theory in Chinese medicine. Chin J Tradit Chin Med Pharm. 2009;24(3):385–8. ISSN: 1673-1727

    Google Scholar 

  12. Feng Y, Wu Z, Zhou X, Zhou Z, Fan W. Knowledge discovery in traditional Chinese medicine: state of the art and perspectives. Artif Intell Med. 2006;38(3):219–36. https://doi.org/10.1016/j.artmed.2006.07.005.

    Article  PubMed  Google Scholar 

  13. Diaoyuan K, Yongxia S. A brief history of human constitutionology. J Tradit Chin Med. 2006;26(3):230–8.

    PubMed  Google Scholar 

  14. Jiang M, Zhang C, Zheng G, Guo HT, Li L, Yang J, et al. Traditional Chinese medicine Zheng in the era of evidence-based medicine: a literature analysis. Evid Based Complement Alternat Med. 2012;409568:1–9. https://doi.org/10.1155/2012/409568.

    Article  Google Scholar 

  15. Ren DC, Yuan WJ, Luo D. The conceptual basis of and new approaches to traditional Chinese medicine. Stud Philos Sci Technol. 2014;31(4):70–5. ISSN: 1674-7062

    Google Scholar 

  16. Gu S, Pei J. Innovating Chinese herbal medicine: from traditional health practice to scientific drug discovery. Front Pharmacol. 2017;8:381. https://doi.org/10.3389/fphar.2017.00381.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Liu H, Li PF, Liu Y. Correlation of Du Meridian and brain. Clinical Journal of Traditional Chinese Medicine. 2015;27(3):332–5. https://doi.org/10.16448/j.cjtcm.2015.0123.

    Article  Google Scholar 

  18. Gao YT, Pan HW, Wu SB. Gross concept ion of anatomical structure of zang-fu viscera in Huangdi Neijing. Chin J Integr Med. 2006;4(4):339–43.

    Article  Google Scholar 

  19. Liao J, Wang J, Liu Y, Li J, Duan L, Chen G, et al. Modern researches on blood stasis syndrome 1989-2015: a bibliometric analysis. Medicine (Baltimore). 2016;95(49):e5533.

    Article  Google Scholar 

  20. Yixing Qiu YX, Huang JH, Jiang XM, Chen Y, Liu Y, Zeng R, et al. Quantitative and qualitative determination of Liuwei Dihuang preparations by ultra high performance liquid chromatography in dual-wavelength fingerprinting mode and random forest. J Sep Sci. 2015;38:3720–6. https://doi.org/10.1002/jssc.201500560.

    Article  CAS  PubMed  Google Scholar 

  21. Yan L, Zhang P, Li M, Fang Q, Yin LL, Wang YZ, et al. Effect of Bushen formulae on T helper cell 1,17 and regulatory T cell in experimental autoimmune encephalomyelitis mice. Chin J ETMF. 2011;17(3):116–21.

    Google Scholar 

  22. Liu Y, Zhao H, Zhang J, Zhang P, Li M, Qi F, et al. The regulatory effect of Liuwei Dihuang pills on cytokines in mice with experimental autoimmune encephalomyelitis. Am J Chin Med. 2012;40(2):295–308. https://doi.org/10.1142/S0192415X12500231.

    Article  PubMed  Google Scholar 

  23. Kang S, Min H. Ginseng, the ‘immunity boost’: the effects of Panax ginseng on immune system. J Ginseng Res. 2012;36(4):354–68. https://doi.org/10.5142/jgr.2012.36.4.354.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Khakzad MR, Ganji A, Ariabod V, Farahani I. Artemisinin therapeutic efficacy in the experimental model of multiple sclerosis. Immunopharmacol Immunotoxicol. 2017;27:1–6. https://doi.org/10.1080/08923973.2017.1379087.

    Article  CAS  Google Scholar 

  25. Li X, Li TT, Zhang XH, et al. Artemisinin analogue SM934 ameliorates murine experimental autoimmune encephalomyelitis through enhancing the expansion and functions of regulatory T cell. PLoS One. 2013;8(8):e74108. https://doi.org/10.1371/journal.pone.0074108.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Zhu C, Xiong Z, Chen X, Peng F, Hu X, Chen Y, et al. Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells. PLoS One. 7:e351254. https://doi.org/10.1371/journal.pone.0035125.

  27. Thomé R, de Carvalho AC, Alves da Costa T, et al. Artesunate ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte migration to the central nervous system. CNS Neurosci Ther. 2016;22(8):707–14. https://doi.org/10.1111/cns.12561.

    Article  CAS  PubMed  Google Scholar 

  28. Fan HC, Ren XR, Yu JZ, Guo MF, Ji N, Sun YS, et al. Suppression of murine EAE by triptolide is related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25(3):222–5.

    CAS  PubMed  Google Scholar 

  29. Fu YF, Zhu YN, Ni J, Zhong XG, Tang W, Zhou R, et al. (5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation. J Neuroimmunol. 2006;175:142–51. https://doi.org/10.1016/j.jneuroim.2006.03.011.

    Article  CAS  PubMed  Google Scholar 

  30. Wang Y, Mei Y, Feng D, Xu L. Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J Neurosci Res. 2008;86(11):2441–9. https://doi.org/10.1002/jnr.21683.

    Article  CAS  PubMed  Google Scholar 

  31. Zhang J, Zeng YQ, Zhang J, Pan XD, Kang DY, Huang TW, et al. Tripchlorolide ameliorates experimental autoimmune encephalomyelitis by down-regulating ERK1/2-NF-κB and JAK/STAT signaling pathways. J Neurochem. 2015;133:104–12. https://doi.org/10.1111/jnc.13058.

    Article  CAS  PubMed  Google Scholar 

  32. Abdin AA, Hasby EA. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats. Eur J Pharmacol. 2014;742:102–12. https://doi.org/10.1016/j.ejphar.2014.09.001.

    Article  CAS  PubMed  Google Scholar 

  33. Wang Y, Cao L, Xu LM. Celastrol ameliorates EAE induction by suppressing pathogenic T cell responses in the peripheral and central nervous systems. J NeuroImmune Pharmacol. 2015;10(3):506–16. https://doi.org/10.1007/s11481-015-9598-9.

    Article  PubMed  Google Scholar 

  34. He Y, Du M, Gao Y, Liu H, Wang H, Wu X, et al. Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels. PLoS ONE. 2013;8(10):e76495. https://doi.org/10.1371/journal.pone.0076495.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. He YX, Du M, Shi HL, Huang F, Liu HS, Wu H, et al. Astragalosides from Radix astragali benefits experimental autoimmune encephalomyelitis in C57BL/6 mice at multiple levels. BMC Complement Altern Med. 2014;313(14):1–11. https://doi.org/10.1186/1472-6882-14-313.

    Article  CAS  Google Scholar 

  36. Xu J, Huang R, Yang YJ, Jin SJ, Zhang JF. Effects of baicalin on apoptosis in rats with autoimmune encephalomyelitis. Zhongguo Dang Dai Er Ke Za Zhi. 2011;13(8):665–8.

    CAS  PubMed  Google Scholar 

  37. Zhang Y, Li X, Ciric B, et al. Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway. Sci Rep. 2015;5:17407. https://doi.org/10.1038/srep17407.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SMY, et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19:245–54. https://doi.org/10.1007/s10787-010-0062-4.

    Article  CAS  PubMed  Google Scholar 

  39. Li W, Zhang Z, Zhang K, Xue Z, Li Y, Zhang Z, et al. Arctigenin suppress Th17 cells and ameliorates experimental autoimmune encephalomyelitis through AMPK and PPAR-γ/ROR-γt signaling. Mol Neurobiol. 2016;53:5356–66.

    Article  CAS  PubMed  Google Scholar 

  40. Marcus DM, Grollman AP. Botanical medicines--the need for new regulations. N Engl J Med. 2002;347(25):2073–6. https://doi.org/10.1056/NEJMsb022858.

    Article  PubMed  Google Scholar 

  41. Liu XY, Sun Y. Clinical and experimental study on multiple sclerosis with Bushen Gusui tablet. Chinese Journal of Integrated Traditional and Western Medicine. 2001;21:1.

    Google Scholar 

  42. Zhao WN. Integrated traditional and western medicine in treating 36 patients with multiple sclerosis. China J Pharm Econ. 2013;1:55–6. ISSN: 1673-5846

    Google Scholar 

  43. Fan YP, Liu XZ, Wang L, Wang YJ, Liu HY. Effects of Erhuang formula on NK cells and cytokines in peripheral blood of EAE rats. J Beijing Univ Tradit Chin Med. 2007;30(3):165–9. ISSN: 1006-2157

    Google Scholar 

  44. Zhou L, Fan Y-P. Clinical research on erhuangfang for reducing axonal injury and recurrence in multiple sclerosis. Chin J Infor Tradit Chin Med. 2012;19(8):14–6.

    Google Scholar 

  45. Wei Z, Wang MX, Hong MF, Diao SP, Liu AQ, Huang YQ, et al. Icariin exerts estrogen-like activity in ameliorating EAE via mediating estrogen receptor β, modulating HPA function and glucocorticoid receptor expression. Am J Transl Res. 2016;8(4):1910–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Yang T, Zheng Q, Wang S, et al. Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice. BMC Complement Altern Med. 2017;2(17):240. https://doi.org/10.1186/s12906-017-1642-2.

    Article  CAS  Google Scholar 

  47. Wang XQ, Tian QQ, Li YH, Liu JC, Liu CY, Yang CY, et al. Immunoregulatory effect of Buyang Huanwu decoction on experimental autoimmune encephalomyelitis mice. J Chin Immunol. 2017;33:52–8. https://doi.org/10.3969/j.issn.1000-484X.

    Article  Google Scholar 

  48. Tian QQ, Li YH, Yu JZ, Wang XQ, Zhang HZ, Liu JC, et al. Immunoregulatory effect of Buyang-Huanwu decoction on monocyte-macrophages in mice with experimental autoimmune encephalomyelitis. Chin J Pathophysiol. 2017;33(2):200–7. ISSN: 1000-4718

    Google Scholar 

  49. Lin J, Xiao L, Ouyang G, Shen Y, Huo R, Zhou Z, et al. Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis. Cell Immunol. 2012;280(2):158–63. https://doi.org/10.1016/j.cellimm.

    Article  Google Scholar 

  50. Zhao M, Liang GP, Tang MN, Luo SY, Zhang J, Cheng WJ, et al. Total glucosides of paeony induces regulatory CD4+CD25+ T cells by increasing Foxp3 demethylation in lupus CD4+ T cells. Clin Immunol. 2012;143:180–7. https://doi.org/10.1016/j.clim.2012.02.002.

    Article  CAS  PubMed  Google Scholar 

  51. Mao QQ, Ip SP, Xian YF, Hu Z, Che CT. Anti-depressant-like effect of peony: a mini-review. Pharm Biol. 2012;50:72–7. https://doi.org/10.3109/13880209.2011.602696.

    Article  CAS  PubMed  Google Scholar 

  52. • Huang Q, Ma X, Zhu DL, et al. Total glucosides of peony attenuates experimental autoimmune encephalomyelitisin C57BL/6 mice. J Neuroimmunol. 2015;284:67–73. https://doi.org/10.1016/j.jneuroim.2015.05.009. First study so far reported biofunction effect of peony on EAE.

    Article  CAS  PubMed  Google Scholar 

  53. Lo YC, Shih YT, Tseng YT, Hsu HT. Neuroprotective effects of San-Huang-Xie-Xin-Tang in the MPP (C)/MPTP models of Parkinson’s disease in vitro and in vivo. Evid Based Complement Alternat Med. 2012;2012:501032–10. https://doi.org/10.1155/2012/501032.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Shih YT, Chen IJ, Wu YC, Lo YC. San-Huang-Xie-Xin-Tang protects against activated microglia- and 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Evid Based Complement Alternat Med. 2011;2011:429384–11. https://doi.org/10.1093/ecam/nep025.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Lee MJ, Choi JH, Lee SJ, Cho I-H. Oriental medicine Samhwangsasim-Tang alleviates experimental autoimmune encephalomyelitis by suppressing Th1 cell responses and upregulating Treg cell responses. Front Pharmacol. 2017;8:192. https://doi.org/10.3389/fphar.2017.00192.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Ma X, Jiang Y, Wu A, Chen X, Pi R, Liu M, et al. Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. PLoS One. 2010;5:e13489. https://doi.org/10.1371/journal.pone.0013489.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Jiang Y, Wu A, Zhu C, Pi R, Chen S, Liu Y, et al. The protective effect of berberine against neuronal damage by inhibiting matrix metalloproteinase-9 and laminin degradation in experimental autoimmune encephalomyelitis. Neurol Res. 2013;35:360–8. https://doi.org/10.1179/1743132812Y.0000-000158.

    Article  CAS  PubMed  Google Scholar 

  58. Luo J, Chen R, Zeng S, Yu J, Jiang G, Wang L, et al. The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. Biochem Biophys Res Commun. 2017;490(3):927–32. https://doi.org/10.1016/j.bbrc.2017.06.142.

    Article  CAS  PubMed  Google Scholar 

  59. Jarząb A, Grabarska A, Skalicka-Woźniak K, et al. Pharmacological features of osthole. Postepy Hig Med Dosw (Online). 2017;71:411–21.

    Article  Google Scholar 

  60. Li YM, Jia M, Li HQ, Zhang ND, Wen X, Rahman K, et al. Cnidium monnieri: a review of traditional uses, phytochemical and Ethnopharmacological properties. Am J Chin Med. 2015;43:835–77. https://doi.org/10.1142/S0192415X15500500.

    Article  CAS  PubMed  Google Scholar 

  61. • Chen X, Pi R, Zou Y, et al. Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin. Eur J Pharmacol. 2010;629:40–6. https://doi.org/10.1016/j.ejphar.2009.12.008. First study so far reported biofunction effect of osthole on EAE.

    Article  CAS  PubMed  Google Scholar 

  62. Gao Z, Wen Q, Xia Y, Yang J, Gao P, Zhang N, et al. Osthole augments therapeutic efficiency of neural stem cells-based therapy in experimental autoimmune encephalomyelitis. J Pharmacol Sci. 2014;124:54–65.

    Article  CAS  PubMed  Google Scholar 

  63. Barbierato M, Facci L, Marinelli C, Zusso M, Argentini C, Skaper SD, et al. Co-ultramicronized Palmitoylethanolami/Luteolin promotes the maturation of oligodendrocyte precursor cells. Sci Rep. 2015;5:16676. https://doi.org/10.1038/srep16676.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Ginwala R, McTish E, Raman C, et al. Apigenin, a natural flavonoid, attenuates EAE severity through the modulation of dendritic cell and other immune cell functions. J Neuroimmune Pharmacol. 2016;11:36–47. https://doi.org/10.1007/s11481-015-9617-x.

    Article  PubMed  Google Scholar 

  65. Zhang ML, Zhang XJ, Kang J, Zhang HJ, Chen XL, Liu N, et al. Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis. Neurosci Lett. 2017;649:100–6. https://doi.org/10.1016/j.neulet.2017.04.005.

    Article  CAS  PubMed  Google Scholar 

  66. Kan QC, Lv P, Zhang XJ, Xu YM, Zhang GX, Zhu L. Matrine protects neuro-axon from CNS inflammation-induced injury. Exp Mol Pathol. 2015;98:124–30. https://doi.org/10.1016/j.yexmp.2015.01.001.

    Article  CAS  PubMed  Google Scholar 

  67. Zhang S, Kan QC, Xu Y, Zhang GX, Zhu L. Inhibitory effect of matrine on blood-brain barrier disruption for the treatment of experimental autoimmune encephalomyelitis. Mediat Inflamm. 2013;736085:1–10. https://doi.org/10.1155/2013/736085.

    Article  CAS  Google Scholar 

  68. Zhao X, Zhang X, Lv Y, Xu Y, Li M, Pan Q, et al. Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis. Immunol Lett. 2016;178:97–104. https://doi.org/10.1016/j.imlet.2016.08.007.

    Article  CAS  PubMed  Google Scholar 

  69. Zhu L, Pan QX, Zhang XJ, Xu YM, Chu YJ, Liu N, et al. Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling. Exp Mol Pathol. 2016;100:337–43. https://doi.org/10.1016/j.yexmp.20-15.12.006.

    Article  CAS  PubMed  Google Scholar 

  70. Liu SQ, Zhang ML, Zhang HJ, et al. Matrine promotes oligodendrocyte development in CNS autoimmunity through the PI3K/Akt signaling pathway. Life Sci. 2017;180:36–41. https://doi.org/10.1016/j.lfs.2017.05.010.

    Article  CAS  PubMed  Google Scholar 

  71. Cai SQ, Wang XA, Shang MY, Xu F, Liu GX. “Efficacy theory” may help to explain characteristic advantages of traditional Chinese medicines. Chin J Chin Mater Med. 2015;40(17):3435–44. https://doi.org/10.4268/cjcmm20151720.

    Article  Google Scholar 

  72. The WHOQOL GROUP. Development of the world health organization WHOQOL-BREF quality of life assessment. Psychol Med. 1998;28:551–8.

    Article  Google Scholar 

  73. Normile D. Asian medicine. The new face of traditional Chinese medicine. Science. 2003;299(5604):188–90. https://doi.org/10.1126/science.299.5604.188.

    Article  CAS  PubMed  Google Scholar 

  74. Brosnan C. Epistemic cultures in complementary medicine: knowledge making in university departments of osteopathy and Chinese medicine. Health Sociol Rev. 2016;25(2):171–86. https://doi.org/10.1080/14461242.2016.1171161.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Wang DL, Calabresec EJ, Liand BL, Lina ZF, Calabreseg V. Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine. Pharmacol Ther. 2018;184:42–50. https://doi.org/10.1016/j.pharmthera.2017.10.013.

    Article  CAS  PubMed  Google Scholar 

  76. Yan EL, Song JL, Liu CN, Hong WX. A research on syndrome element differentiation based on phenomenology and mathematical method. Chin Med. 2017;12:19. https://doi.org/10.1186/s13020-017-0141-1.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Xueseng Q. On human science and modern science and technology [C]. Shanghai: Shanghai Jiao Tong University Press; 1998.

    Google Scholar 

  78. Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, et al. Synergistic effects of Chinese herbal medicine: a comprehensive review of methodology and current research. Front Pharmacol. 2016;7:201. https://doi.org/10.3389/fphar.2016.00201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Yang X. Chinese traditional medicine: the nature and the roadmap to modernization. Smar Health. 2015;1(1):60–4.

    Google Scholar 

  80. Du GH, Wang YH, Zhang R, Tan CB, He XL, Hu JJ, et al. Multi-target and multi-component pattern, a superficial understanding of the action mechanism of traditional Chinese medicine. Modern Tradi Chin Med Mater Med-World Sci Tech. 2009;4:480–4.

    Google Scholar 

  81. Graziose R, Lila MA, Raskin I. Merging traditional chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. Curr Drug Discov Technol. 2010;7(1):2–22. PMCID: PMC3017680

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Wei ZS, Deng XM, Hong MF, Su QX, Liu AQ, Huang YQ, et al. Icariin has synergistic effects with methylprednisolone to ameliorate EAE via modulating HPA function, promoting anti-inflammatory and anti-apoptotic effects. Int J Clin Exp Med. 2015;8(11):20188–97. PMCID: PMC4723776

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Zhou YQ, Mao WQ, Zhang XJ, et al. Preliminary report of effect of shuganjianpigusuifang on relapse of multiple sclerosis. J Integr Tradit Chin West Med. 2013;33:31–2. ISSN: 1672-0415

    CAS  Google Scholar 

  84. Li Z, Xu B, Zhu YH. Clinical observation of shuganjianpigusuifang combined with conventional therapy in treating acute of multiple sclerosis. J Emerg Tradit Chin Med. 2014;23:1627–9.

    Google Scholar 

  85. Duan L. Clinical efficacy of yiqihuoxuehuatan decoction in treating multiple sclerosis. Hebei Med J. 2013;35:460–1.

    Google Scholar 

  86. Zeng HM, Zhang Ming M, Zhang G, Zi XF. A clinical effect observation on the Buyang Huanwu decoction with hormone treatment for multiple sclerosis. Pract Clin Med. 2009;10(10):9–14.

    Google Scholar 

  87. Di L, Xiao-Chun L. New developments in the pharmacodynamics and pharmacokinetics of combination of Chinese medicine and western medicine. Chin J Integr Med. 2017;23(4):312–9. https://doi.org/10.1007/s11655-016-2271-1.

    Article  CAS  Google Scholar 

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Acknowledgments

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding

This work was supported by grants (to X. Chen) from the Israel Science Foundation (ISF)—the National Natural Science Foundation of China (NSFC) joint program (813111290).

Author information

Author notes

  1. Hao Chen and Xiaomeng Ma contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China

    Hao Chen, Xiaomeng Ma, Lei Si, Zhaoyu Chen, Xiuli Lin & Xiaohong Chen

  2. Department of Traditional Chinese Medicine, Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China

    Yuewu Yang

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  1. Hao Chen
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Chen, H., Ma, X., Si, L. et al. Traditional Chinese Medicine in Multiple Sclerosis: Theory and Practice. Curr Pharmacol Rep 4, 436–446 (2018). https://doi.org/10.1007/s40495-018-0158-x

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