Skip to main content
Log in

The New US Heart Allocation Scheme: Impact on Waitlist and Post-Transplant Survival

  • Thoracic Transplantation (J Patel and AM Holm, Section Editors)
  • Published:
Current Transplantation Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

In October 2018, the Organ Procurement and Transplantation Network (OPTN) revised the donor heart allocation system in an attempt to prioritize those patients with highest clinical urgency, reduce waitlist morality, and improve geographic equity in organ allocation. Our goal was to review the changes in the heart allocation policy and its impact on transplant characteristics and outcomes.

Recent Findings

After the new 2018 donor heart allocation system became effective, there has been a trend toward increased use of temporary mechanical circulatory support. Also, initial reports suggested reduced post-transplant survival, although the initial analysis was limited by short follow-up and small sample size. Recent reports however illustrate survival outcomes similar to those of the previous allocation system.

Summary

The new donor heart allocation policy has been associated with a change in management strategies for bridging patients to transplantation, with increased utilization of temporary mechanical circulatory support, with still uncertain effects on post-transplant survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Schlendorf KH, Zalawadiya S, Shah AS, Wigger M, Chung CY, Smith S, et al. Early outcomes using hepatitis C-positive donors for cardiac transplantation in the era of effective direct-acting anti-viral therapies. J Heart Lung Transplant. 2018;37:763–9.

    Article  Google Scholar 

  2. Mudge GH, Goldstein S, Addonizio LJ, Caplan A, Mancini D, Levine TB, et al. 24th Bethesda conference: cardiac transplantation. Task Force 3: recipient guidelines/prioritization. J Am Coll Cardiol. 1993;22:21–31.

    Article  CAS  Google Scholar 

  3. Singh TP, Almond C, Givertz MM, Piercey G, Gauvreau K. Improved survival in heart transplant recipients in the United States: racial differences in era effect. Circ Heart Fail. 2011;4:153–60.

    Article  Google Scholar 

  4. Givertz MM. Heart allocation in the United States: intended and unintended consequences. Circ Heart Fail. 2012;5:140–3.

    Article  Google Scholar 

  5. Stevenson LW, Kormos RL, Young JB, Kirklin JK, Hunt SA. Major advantages and critical challenge for the proposed United States heart allocation system. J Heart Lung Transplant. 2016;35:547–9.

    Article  Google Scholar 

  6. Hussong S. Administrative developments: DHHS issues organ allocation final rule. J Law Med Ethics. 1999;27:380–2.

    Article  CAS  Google Scholar 

  7. OPTN Final Rule: allocation of organs. 42 CFR Part 121.8.

  8. Committee OTT. Four-month monitoring of heart allocation proposal to modify the heart allocation system. 2019.

    Google Scholar 

  9. • Cogswell R, John R, Estep JD, Duval S, Tedford RJ, Pagani FD, et al. An early investigation of outcomes with the new 2018 donor heart allocation system in the United States. J Heart Lung Transplant. 2020;39:1–4 This study was the first analysis of early outcomes with the new donor allocation system change and highlighted the possibility of decreased post-transplant survival.

    Article  Google Scholar 

  10. • Jawitz OK, Fudim M, Raman V, Bryner BS, DeVore AD, Mentz RJ, et al. Reassessing recipient mortality under the new heart allocation system: an updated UNOS registry analysis. JACC Heart Fail. 2020; This study provided longer follow-up to assess outcomes with the new donor allocation system, and demonstrated that post-transplant survival in the new system was comparable to post-transplant survival in the previous allocation system.

  11. Goff RR, Uccellini K, Lindblad K, Hall S, Davies R, Farr M, et al. A change of heart: preliminary results of the US 2018 adult heart allocation revision. Am J Transplant. 2020.

  12. Varshney AS, Berg DD, Katz JN, Baird-Zars VM, Bohula EA, Carnicelli AP, Chaudhry SP, Guo J, Lawler PR, Nativi-Nicolau J, Sinha SS, Teuteberg JJ, van Diepen S, Morrow DA and Critical Care Cardiology Trials Network I. Use of temporary mechanical circulatory support for management of cardiogenic shock before and after the United Network for Organ Sharing donor heart allocation system changes. JAMA Cardiol. 2020.

  13. Teuteberg JJ, Cleveland JC Jr, Cowger J, Higgins RS, Goldstein DJ, Keebler M, et al. The Society of Thoracic Surgeons Intermacs 2019 annual report: the changing landscape of devices and indications. Ann Thorac Surg. 2020;109:649–60.

    Article  Google Scholar 

  14. Hanff TC, Harhay MO, Kimmel SE, Birati EY, Acker MA. Update to an early investigation of outcomes with the new 2018 donor heart allocation system in the United States. J Heart Lung Transplant. 2020;39:725–6.

    Article  Google Scholar 

  15. Davies RR, Goff RR, Lease ED, Daly RC, Hall S. Commentary in reply to Cogswell et al.: An early investigation of outcomes with the new 2018 donor heart allocation system in the United States. J Heart Lung Transplant. 2020.

  16. Kilic A, Hickey G, Mathier MA, Kormos RL, Sultan I, Gleason TG, et al. Outcomes of the first 1300 adult heart transplants in the United States after the allocation policy change. Circulation. 2020;141:1662–4.

    Article  Google Scholar 

  17. Clinical trial to evaluate the safety and effectiveness of the portable Organ Care System (OCS™) heart for resuscitation, preservation and assessment of hearts from donors after circulatory death (DCD Heart Trial). ClinicalTrialsgov Identifier: NCT03831048.

  18. Stevenson LW. Crisis awaiting heart transplantation: sinking the lifeboat. JAMA Intern Med. 2015;175:1406–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Melissa A. Lyle.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Thoracic Transplantation

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lyle, M.A., Vega, J.D. The New US Heart Allocation Scheme: Impact on Waitlist and Post-Transplant Survival. Curr Transpl Rep 7, 340–345 (2020). https://doi.org/10.1007/s40472-020-00301-2

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40472-020-00301-2

Keywords

Navigation