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Promise of Normothermia

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Abstract

Purpose of this Review

Normothermic ex vivo machine perfusion (NMP) is a novel preservation modality that has been investigated as a tool to preserve and protect organs from extended criteria donors (ECDs). This review summarizes the latest clinical and experimental progress in this field and tries to answer questions such as what are the future implications of NMP, what are its therapeutic potentials, and what are the limitations associated with this technology?

Recent Findings

New emerging data from clinical trials with NMP devices have demonstrated the safety and feasibility of this technology as well as its ability to preserve allograft function during the preservation period.

Summary

NMP provides potential solutions to limitations associated with the standard cold preservation modality. It maintains the allografts in a physiological state, prevents depletion of cellular energy sources, enables resuscitation and assessment of the ECD organ, and opens the door for future ex vivo therapeutic interventions. Hence, it should increase donor pool and positively impact transplant outcomes.

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Abbreviations

NMP:

Normothermic ex vivo perfusion

IRI:

Ischemia reperfusion injury

CSP:

Cold static preservation

MSCs:

Mesenchymal stem cells

ECD:

Extended criteria donors

DCD:

Donation after cardiac death

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Authors and Affiliations

  1. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    Babak Banan

  2. Department of Surgery, Washington University School of Medicine, S. Euclid Ave, Campus, Box 8109, St. Louis, MO, 63110, USA

    William Chapman

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  1. Babak Banan
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  2. William Chapman
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Correspondence to William Chapman.

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Babak Banan declares no conflict of interest. William Chapman reports personal fees from Pathfinder Therapeutics, personal fees from Novartis Pharmaceuticals outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Banan, B., Chapman, W. Promise of Normothermia. Curr Transpl Rep 4, 42–51 (2017). https://doi.org/10.1007/s40472-017-0137-x

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