Abstract
Purpose
The aim of the present systematic review was to provide an overview on the different positron emission tomography (PET) hypoxia radiotracers in the clinical setting of lung cancer.
Methods
We performed a comprehensive literature review on the role of PET hypoxia imaging in lung cancer using the electronic databases PubMed and Scopus to select English written language articles on humans from January 2007 to February 2017. The following keywords have been used: “hypoxia” or “hypoxic” and “PET” and “lung cancer”. Reviews, clinical reports, and editorial articles were excluded.
Results
Originally, we considered 76 manuscripts, coming to a selection of 37 original articles. In particular, the selected original articles included the following PET radiotracer categories: nitroimidazole compounds, glucose analogue and bis(thiosemicarbazone) complexes. PET radiotracers, particularly nitroimidazole compounds, are the most suitable method to directly identify the presence of hypoxia in lung cancer.
Conclusions
Based on the literature review, the definition of the role of clinical application of PET hypoxia radiotracers has been provided reporting that in vivo hypoxia imaging is needed for effective treatment selection, individual treatment planning, and treatment monitoring in oncology.
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This work was supported by the Italian Ministry of Health, Ricerca Finalizzata GR-2009-1575612.
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EI: Project development, literature search and review, content planning, manuscript writing and editing, final approval of the version to be published. PM: Content planning, manuscript writing and editing, final approval of the version to be published. MV: Literature search and final approval of the version to be published. FF: Critical revision of literature, manuscript editing and final approval of the version to be published. CM: Manuscript editing and final approval of the version to be published. VB: Critical revision of literature, manuscript editing and final approval of the version to be published. RMM: Critical revision of literature, manuscript editing and final approval of the version to be published. LG: Final approval of the version to be published. MP: Project development, content planning, manuscript writing and editing, final approval of the version to be published.
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E Incerti, P. Mapelli, M. Vuozzo, F. Fallanca, C. Monterisi, V. Bettinardi, R.M. Moresco, L. Gianolli, M. Picchio declare that they have no conflict of interest.
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Patient of Fig. 2 signed an informed consent prior to study participation, according to the Declaration of Helsinki and the protocol was approved by the local Ethical Committee (EudraCT Number: 2011-002647-98).
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Incerti, E., Mapelli, P., Vuozzo, M. et al. Clinical PET imaging of tumour hypoxia in lung cancer. Clin Transl Imaging 5, 427–445 (2017). https://doi.org/10.1007/s40336-017-0243-x
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DOI: https://doi.org/10.1007/s40336-017-0243-x