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Relationship Between Calcium Channel Blockers Therapy and Cognitive Function Improvement in Cognitive Decline Patients with Cerebrovascular Disease

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Abstract

Introduction

Amlodipine belongs to a class of calcium channel blockers that relax blood vessels to allow easier flow of blood. Higher blood pressure (BP) is associated with cerebrovascular disease and is an important contributor to cognitive decline and dementia.

Aim

This study aimed to evaluate the effect of 24 weeks of S-amlodipine besylate therapy on cognitive function in patients with hypertension and cerebrovascular disease.

Methods

The data were obtained from a study of post-market surveillance of S-amlodipine besylate.

Results

A total of 545 subjects (mean age 67 ± 9.68 years) with hypertension and ischemic cerebrovascular disease were enrolled. Patients with a baseline Mini-Mental State Examination (MMSE) score above 26 were assigned to the cognitive normal (CN) (n = 294) group, and those with MMSE score less than 26 were in the cognitive decline (CD) (n = 251) group. After 24 weeks of treatment with S-amlodipine besylate 5 mg, MMSE and Global Deterioration Scale (GDS) were evaluated again. Changes in MMSE were compared in the target BP reached (TBPR) and non-reached (NTBPR) groups and for CN and CD groups. Treatment with 5 mg of S-amlodipine besylate for 24 weeks improved MMSE and GDS scores (p < 0.001). The CD group showed improvement in MMSE score regardless of whether target BP was obtained (TBPR: p < 0.001, NTBPR: p < 0.01). However, the CN classification was not significant for either TBPR or NTBPR groups.

Conclusions

S-amlodipine besylate improved cognition of the CD group with hypertension and cerebrovascular disease regardless of obtaining target BP.

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Data Availability

The data used in this study are available from the corresponding author upon reasonable request.

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Acknowledgements

We would like to thank Editage (www.editage.co.kr) for English language editing.

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Authors and Affiliations

  1. Department of Neurology, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, Korea

    Ho Tae Jeong, Kwang-Yeol Park & Young Chul Youn

  2. Department of Clinical Laboratory Science, Dongnam Health University, Suwon, 16328, Korea

    Hyun-Ho Sung

  3. Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang-si, 10444, Korea

    Jun Hong Lee

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  1. Ho Tae Jeong
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All authors contributed significantly to the conceptualization and writing of this manuscript.

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Correspondence to Young Chul Youn.

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Jeong, H.T., Sung, HH., Lee, J.H. et al. Relationship Between Calcium Channel Blockers Therapy and Cognitive Function Improvement in Cognitive Decline Patients with Cerebrovascular Disease. High Blood Press Cardiovasc Prev 29, 595–600 (2022). https://doi.org/10.1007/s40292-022-00538-1

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  • DOI: https://doi.org/10.1007/s40292-022-00538-1

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