Abstract
Background
To date, no evidence exists in the literature as to the effects of inhaled corticosteroids (ICs) on salivary composition in patients with bronchial asthma.
Objective
The aim of this study was to assess the effect of ICs on salival composition.
Methods
Adult patients attending an outpatient respiratory clinic who were classified into two groups (controls and patients with bronchial asthma receiving ICs), were recruited in this cross-sectional study. For each participant, data of clinical records, baseline history of asthma, and regular IC dose were recorded. A sample of stimulated saliva was collected and processed for investigation of mucin 5B (MUC5B), lipoxygenase (LPO), total antioxidant capacity, and 8-hydroxydeoxyguanosine (8-OHdG) levels.
Results
Overall, 103 patients (49 controls and 54 patients receiving regular treatment with ICs) were recruited. No differences in comorbidities or smoking habits were observed. Patients treated with high-doses of ICs showed lower levels of salival MUC5B compared with those treated with medium IC doses or those not treated with ICs (1.60 vs. 2.20 vs. 2.53 ng/mL; p = 0.042).
Conclusion
In patients with asthma, treatment with high-doses of ICs is associated with reduced levels of salivary MUC5B. This effect can explain some of the effects of ICs on oral health.
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Acknowledgments
The authors would like to thank Mrs. Huda Khaldy from the Immunoanalysis and Radiobiochemistry Unit, University of Granada, who made the determination of salivary compounds possible.
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Funding
This study was funded by Fundación Respira 255|2012 and FIS Project PI10/00932 of the Spanish Ministry of Science and Innovation, Health Institute Carlos III, in the hallmark of Research Group CTS-654 ‘Investigación Farmacológica en Odontología’ from Junta de Andalucía (Spain).
Conflict of interest
Bernardino Alcázar Navarrete reports receiving personal fees from Novartis AG, Boehringer-Ingelheim, GlaxoSmithKline, Almirall, and Astra-Zeneca, as well as grants and personal fees from Menarini, outside the submitted work. Pedro José Romero Palacios, Antonio Aguilar-Salvatierra, Javier Guardia, and Gerardo Gómez-Moreno have no conflicts of interest to disclose.
Ethical approval
This study was performed in accordance with the Declaration of Helsinki 1964 and its amendments. The study protocol, patient information and informed consent form were reviewed and approved by the responsible Ethics Committee of the Faculty of Medicine and Dentistry, University of Granada, Granada, Spain.
Informed consent
Informed consent was obtained from all individual participants in this study.
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Navarrete, B.A., Palacios, P.J.R., Aguilar-Salvatierra, A. et al. Effect of Inhaled Corticosteroids on Salival Composition: A Cross-Sectional Study in Patients with Bronchial Asthma. Clin Drug Investig 35, 569–574 (2015). https://doi.org/10.1007/s40261-015-0313-7
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DOI: https://doi.org/10.1007/s40261-015-0313-7