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Quality-of-Life Research in Acne Vulgaris: Current Status and Future Directions

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Abstract

Acne patients may have significant quality-of-life (QoL) impairment, therefore assessment of health-related QoL (HRQoL) in acne patients is recommended by several national and international guidelines as an integral part of acne management. The inclusion of QoL assessment in core outcome sets is now a popular idea. Several acne-specific QoL questionnaires are available but none cover all topics presented in other instruments. The impact of acne on different aspects of QoL may vary between patients from different age groups. The European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes has initiated a study on the relevance of the different QoL topics in acne patients. Detailed recommendations on treatment goals and changes of treatment approaches based on a validated banding system and a minimal clinically important difference in HRQoL questionnaires (such as the Dermatology Life Quality Index) may be an important and promising approach.

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References

  1. Ring J. Quality of life—an essential parameter for dermatology. J Eur Acad Dermatol Venereol. 2017;31(4):573.

    Article  CAS  PubMed  Google Scholar 

  2. Finlay AY. Quimp: a word meaning “quality of life impairment”. Acta Derm Venereol. 2017;97(4):546–7.

    Article  PubMed  Google Scholar 

  3. Chernyshov PV, Linder MD, Pustišek N, Manolache L, Szepietowski JC, Tomas-Aragones L, et al. Quimp (quality of life impairment): an addition to the quality of life lexicon. J Eur Acad Dermatol Venereol. 2018;32(5):e181–2.

    Article  CAS  PubMed  Google Scholar 

  4. Chernyshov PV, Zouboulis CC, Tomas-Aragones L, et al. Quality of life measurement in acne. Position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa. J Eur Acad Dermatol Venereol. 2018;32:194–208.

    Article  CAS  PubMed  Google Scholar 

  5. Chernyshov P. Dermatological quality of life instruments in children. G Ital Dermatol Venereol. 2013;148:277–85.

    CAS  PubMed  Google Scholar 

  6. Nast A, Dréno B, Bettoli V, et al. European evidence-based (S3) guideline for the treatment of acne—update 2016—short version. J Eur Acad Dermatol Venereol. 2016;30:1261–8.

    Article  CAS  PubMed  Google Scholar 

  7. Finlay AY, Salek MS, Abeni D, et al. Why quality of life measurement is important in dermatology clinical practice: an expert-based opinion statement by the EADV Task Force on Quality of Life. J Eur Acad Dermatol Venereol. 2017;31:424–31.

    Article  CAS  PubMed  Google Scholar 

  8. Chernyshov PV, Tomas-Aragones L, Manolache L, Svensson A, Marron SE, Evers AWM, et al. Which acne treatment has the best influence on health-related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes. J Eur Acad Dermatol Venereol. 2018;32(9):1410–9.

    Article  CAS  PubMed  Google Scholar 

  9. Rzany B. Too many instruments for measuring Quality of Life in atopic dermatitis. J Eur Acad Dermatol Venereol. 2017;31(4):574.

    Article  CAS  PubMed  Google Scholar 

  10. Kottner J, Jacobi L, Hahnel E, Alam M, Balzer K, Beeckman D, et al. Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative. Br J Dermatol. 2018;178(4):e279–85.

    Article  CAS  PubMed  Google Scholar 

  11. Layton AM, Eady EA, Thiboutot DM, Tan J, Acne Core Outcomes Research Network (ACORN) Outcomes Identification Group. Identifying what to measure in acne clinical trials: first steps towards development of a core outcome set. J Invest Dermatol. 2017;137(8):1784–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Motley RJ, Finlay AY. How much disability is caused by acne? Clin Exp Dermatol. 1989;14:194–8.

    Article  CAS  PubMed  Google Scholar 

  13. Motley RJ, Finlay AY. Practical use of a disability index in the routine management of acne. Clin Exp Dermatol. 1992;17:1–3.

    Article  CAS  PubMed  Google Scholar 

  14. Girman CJ, Hartmaier S, Thiboutot D, Johnson J, Barber B, DeMuro-Mercon C, et al. Evaluating health-related quality of life in patients with facial acne: development of a self-administered questionnaire for clinical trials. Qual Life Res. 1996;5:481–90.

    Article  CAS  PubMed  Google Scholar 

  15. Martin AR, Lookingbill DP, Botek A, Light J, Thiboutot D, Girman CJ. Health-related quality of life among patients with facial acne: assessment of a new acne-specific questionnaire. Clin Exp Dermatol. 2001;26:380–5.

    Article  CAS  PubMed  Google Scholar 

  16. Tan J, Fung K, Khan S. Condensation and validation of a 4-item index of the acne-QoL. Qual Life Res. 2006;15:1203–10.

    Article  PubMed  Google Scholar 

  17. Gupta MA, Johnson AM, Gupta AK. The development of an Acne Quality of Life scale: reliability, validity, and relation to subjective acne severity in mild to moderate acne vulgaris. Acta Derm Venereol. 1998;78:451–6.

    Article  CAS  PubMed  Google Scholar 

  18. Rapp SR, Feldman SR, Graham G, Fleischer AB, Brenes G, Dailey M. The Acne Quality of Life Index (Acne-QOLI): development and validation of a brief instrument. Am J Clin Dermatol. 2006;7:185–92.

    Article  PubMed  Google Scholar 

  19. Layton AM, Seukeran D, Cunliffe WJ. Scarred for life? Dermatology. 1997;195(Suppl 1):15–21 (discussion 38–40).

    Article  PubMed  Google Scholar 

  20. Alexis A, Daniels SR, Johnson N, Pompilus F, Burgess SM, Harper JC. Development of a new patient-reported outcome measure for facial acne: the Acne Symptom and Impact Scale (ASIS). J Drugs Dermatol. 2014;13:333–40.

    PubMed  Google Scholar 

  21. McLellan C, Frey MP, Thiboutot D, Layton A, Chren MM, Tan J. Development of a comprehensive quality-of-life measure for facial and torso acne. J Cutan Med Surg. 2018;22(3):304–11.

    Article  PubMed  Google Scholar 

  22. Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI): a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19(3):210–6.

    Article  CAS  PubMed  Google Scholar 

  23. Lewis V, Finlay AY. 10 years experience of the dermatology Life Quality Index (DLQI). J Investig Dermatol Symp Proc. 2004;9(2):169–80.

    Article  PubMed  Google Scholar 

  24. Basra MK, Salek MS, Camilleri L, Sturkey R, Finlay AY. Determining the minimal clinically important difference and responsiveness of the Dermatology Life Quality Index (DLQI): further data. Dermatology. 2015;230:27–33.

    Article  CAS  PubMed  Google Scholar 

  25. Chren MM, Lasek RJ, Flocke SA, Zyzanski SJ. Improved discriminative and evaluative capability of a refined version of Skindex, a quality-of-life instrument for patients with skin diseases. Arch Dermatol. 1997;133:1433–40.

    Article  CAS  PubMed  Google Scholar 

  26. Chren MM. The Skindex instruments to measure the effects of skin disease on quality of life. Dermatol Clin. 2011;30(2):231–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Lewis-Jones MS, Finlay AY. The Children’s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132:942–9.

    Article  CAS  PubMed  Google Scholar 

  28. Waters A, Sandhu D, Beattie P, Ezughah F, Lewis-Jones S. Severity stratification of Children’s Dermatology Life Quality Index (CDLQI) scores. Br J Dermatol. 2010;163:121.

    Google Scholar 

  29. Finlay AY, Basra MKA. DLQI and CDLQI scores should not be combined. Br J Dermatol. 2012;167:453–4.

    Article  CAS  PubMed  Google Scholar 

  30. Basra MK, Sue-Ho R, Finlay AY. The Family Dermatology Life Quality Index: measuring the secondary impact of skin disease. Br J Dermatol. 2007;156(3):528–38.

    Article  CAS  PubMed  Google Scholar 

  31. Chernyshov PV, Kaliuzhna LD, Reznikova AA, Basra MK. Comparison of the impairment of family quality of life assessed by disease-specific and dermatology-specific instruments in children with atopic dermatitis. J Eur Acad Dermatol Venereol. 2015;29(6):1221–4.

    Article  CAS  PubMed  Google Scholar 

  32. Chernyshov P, de Korte J, Tomas-Aragones L, Lewis-Jones S, EADV Quality of Life Task Force. EADV Taskforce’s recommendations on measurement of health-related quality of life in paediatric dermatology. J Eur Acad Dermatol Venereol. 2015;29(12):2306–16.

    Article  CAS  PubMed  Google Scholar 

  33. Finlay AY. Broader concepts of quality of life measurement, encompassing validation. J Eur Acad Dermatol Venereol. 2017;31:1254–9.

    Article  CAS  PubMed  Google Scholar 

  34. Griffiths CEM, Augustin M, Naldi L, et al. Patient-dermatologist agreement in psoriasis severity, symptoms and satisfaction: results from a real-world multinational survey. J Eur Acad Dermatol Venereol. 2018;32(9):1523–9.

    Article  CAS  PubMed  Google Scholar 

  35. Walker N, Lewis-Jones MS. Quality of life and acne in Scottish adolescent schoolchildren: use of the Children’s Dermatology Life Quality Index (CDLQI) and the Cardiff Acne Disability Index (CADI). J Eur Acad Dermatol Venereol. 2006;20:45–50.

    Article  CAS  PubMed  Google Scholar 

  36. Tasoula E, Gregoriou S, Chalikias J, Lazarou D, Danopoulou I, Katsambas A, et al. The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece. Results of a population survey. An Bras Dermatol. 2012;87(6):862–9.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Jankovic S, Vukicevic J, Djordjevic S, Jankovic J, Marinkovic J. Quality of life among schoolchildren with acne: results of a cross-sectional study. Indian J Dermatol Venereol Leprol. 2012;78:454–8.

    Article  PubMed  Google Scholar 

  38. Fabbrocini G, Cacciapuoti S, Monfrecola G. A qualitative investigation of the impact of acne on Health-Related Quality of Life (HRQL): development of a Conceptual Model. Dermatol Ther (Heidelb). 2018;8(1):85–99.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Chernyshov PV. Stigmatization and self-perception in children with atopic dermatitis. Clin Cosmet Investig Dermatol. 2016;9:159–66.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Pochynok T, Chernyshov IP, Asayevich N, Sushko S, Kopylova V, Chernyshov PV. Quality of life of school and university students with acne. Acta Dermatovenerol Croat. 2018;26(2):139–45.

    PubMed  Google Scholar 

  41. Chernyshov PV, Petrenko A, Kopylova V. What health-related quality of life factors influence the decision of patients with acne to visit a dermatologist? J Clin Aesthet Dermatol. 2018;11(7):21–5.

    PubMed  PubMed Central  Google Scholar 

  42. Chernyshov PV. Gender differences in health-related and family quality of life in young children with atopic dermatitis. Int J Dermatol. 2012;51(3):290–4.

    Article  PubMed  Google Scholar 

  43. Chernyshov PV, Ho RC, Monti F, Jirakova A, Velitchko SS, Hercogova J, et al. Gender differences in self-assessed health-related quality of life in children with atopic dermatitis. J Clin Aesthet Dermatol. 2016;9(8):19–24.

    PubMed  PubMed Central  Google Scholar 

  44. Chernyshov PV. The evolution of quality of life assessment and use in dermatology. Dermatology. 2019. https://doi.org/10.1159/000496923.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, Royo Villanova Hospital, Aragon Psychodermatology Research Group (GAI + PD), Avda. San Gregorio, 30, 50015, Saragossa, Spain

    Servando E. Marron

  2. Department of Dermatology and Venereology, National Medical University, Bulvar Shevchenko 13, Kiev, 01601, Ukraine

    Pavel V. Chernyshov

  3. Department of Psychology, University of Zaragoza, C/Pedro Cerbuna 12, 50009, Saragossa, Spain

    Lucia Tomas-Aragones

Authors
  1. Servando E. Marron
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  2. Pavel V. Chernyshov
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  3. Lucia Tomas-Aragones
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Correspondence to Servando E. Marron.

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No funding was received for the preparation of this manuscript.

Conflicts of interest

Servando Marron, Pavel Chernyshov and Lucia Tomas-Aragones have no conflicts of interest to declare.

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Marron, S.E., Chernyshov, P.V. & Tomas-Aragones, L. Quality-of-Life Research in Acne Vulgaris: Current Status and Future Directions. Am J Clin Dermatol 20, 527–538 (2019). https://doi.org/10.1007/s40257-019-00438-6

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  • DOI: https://doi.org/10.1007/s40257-019-00438-6

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