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Mitochondrion-anchoring AIEgen with Large Stokes Shift for Imaging-guided Photodynamic Therapy

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Abstract

Photosensitizers that can target and accumulate in mitochondria are expected to achieve good therapeutic effects in photodynamic therapy, as mitochondria are the energy generation factory in cells. Herein, we designed and synthesized a novel mitochondrion-targeting photosensitizer TPC-Py with aggregation-induced emission characteristics for image-guided photodynamic therapy. TPC-Py possessed an efficient production of 1O2, with a quantum yield of 11.65%, upon mild white light irradiation (6 mW/cm2). TPC-Py exhibited good biocompatibility under dark condition, but showed remarkable cytotoxicity towards human cervical carcinoma(HeLa) cells with a half maximal inhibitory concentration(IC50) of 3.2 µmol/L when exposed to white light irradiation(14.4 J/cm2). In addition, the Stokes shift of TPC-Py was as high as 150 nm, so that it could prevent self-absorption and increase the signal-to-noise ratio of fluorescence imaging. The excellent performance of TPC-Py makes it a promising candidate in imaging-guided clinical PDT for cancer in the near future.

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References

  1. Zhou L., Ge X., Zhou J., Wei S., Shen J., RSC Adv., 2015, 5, 2794

    Article  CAS  Google Scholar 

  2. Castano A. P., Demidova T. N., Hamblin M. R., Photodiagn. Photodyn, 2004, 1, 279

    Article  CAS  Google Scholar 

  3. Foote C. S., Photochem. Photobiol., 1991, 54, 659

    Article  CAS  Google Scholar 

  4. Triesscheijn M., Baas P., Schellens J. H., Stewart F. A., Oncologist, 2006, 11, 1034

    Article  CAS  Google Scholar 

  5. Th F., Kasper K., Z. Phys. Chem., 1954, 1, 275

    Article  Google Scholar 

  6. Luo J., Xie Z., Lam J. W., Cheng L., Chen H., Qiu C., Kwok H. S., Zhan X., Liu Y., Zhu D., Tang B. Z., Chem. Commun., 2001, 1740

  7. Ren Y., Lam J. W., Dong Y., Tang B. Z., Wong K. S., J. Phys. Chem. B, 2005, 109, 1135

    Article  CAS  Google Scholar 

  8. Würthner F., Angew. Chem. Int. Ed., 2020, 59, 14192

    Article  Google Scholar 

  9. Alifu N., Dong X. B., Li D. Y., Sun X. H., Zebibula A., Zhang D. Q., Zhang G. X., Qian J., Mater. Chem. Front, 2017, 1, 1746

    Article  CAS  Google Scholar 

  10. Geng J. L., Li K., Ding D., Zhang X. H., Qin W., Liu J. Z., Tang B. Z., Liu B., Small, 2012, 8, 3655

    Article  CAS  Google Scholar 

  11. Gao Y., Wang X., He X., He Z., Yang X., Tian S., Meng F., Ding D., Luo L., Tang B. Z., Adv. Funct. Mater., 2019, 29, 1902673

    Article  Google Scholar 

  12. He Z., Gao Y., Zhang H., Wang X., Meng F., Luo L., Tang B. Z., Chem. Commun., 2020, 56, 7785

    Article  CAS  Google Scholar 

  13. Zhu C., Kwok R. T. K., Lam J. W. Y., Tang B. Z., ACS Appl. Bio. Mater., 2018, 1, 1768

    Article  CAS  Google Scholar 

  14. Ochsner M., J. Photochem. Photobiol. B: Biol., 1997, 39, 1

    Article  CAS  Google Scholar 

  15. Feng G., Liu J., Zhang C. J., Liu B., ACS Appl. Mater. Interfaces, 2018, 10, 11546

    Article  CAS  Google Scholar 

  16. Zielonka J., Joseph J., Sikora A., Hardy M., Ouari O., Vasquez-Vivar J., Cheng G., Lopez M., Kalyanaraman B., Chem. Rev., 2017, 117, 10043

    Article  CAS  Google Scholar 

  17. Gui C., Zhao E., Kwok R. T. K., Leung A. C. S., Lam J. W. Y., Jiang M., Deng H., Cai Y., Zhang W., Su H., Tang B. Z., Chem. Sci., 2017, 8, 1822

    Article  CAS  Google Scholar 

  18. Qu Y., Jin B., Liu Y., Wu Y., Yang L., Wu J., Hua J., Tetrahedron Lett., 2013, 54, 4942

    Article  CAS  Google Scholar 

  19. Zhang R., Feng G., Zhang C. J., Cai X., Cheng X., Liu B., Anal. Chem., 2016, 88, 4841

    Article  CAS  Google Scholar 

  20. Xu S., Yuan Y., Cai X., Zhang C.-J., Hu F., Liang J., Zhang G., Zhang D., Liu B., Chem. Sci., 2015, 6, 5824

    Article  CAS  Google Scholar 

  21. Feng G., Liu B., Small, 2016, 12, 6528

    Article  CAS  Google Scholar 

  22. Gu B., Wu W., Xu G., Feng G., Yin F., Chong P. H. J., Qu J., Yong K. T., Liu B., Adv. Mater., 2017, 29, 1701076

    Article  Google Scholar 

  23. Jiang M., Gu X., Lam J. W. Y., Zhang Y., Kwok R. T. K., Wong K. S., Tang B. Z., Chem. Sci., 2017, 8, 5440

    Article  CAS  Google Scholar 

  24. Grabowski Z. R., Rotkiewicz K., Rettig W., Chem. Rev., 2003, 103, 3899

    Article  Google Scholar 

  25. Reichardt C., Chem. Rev., 1994, 94, 2319

    Article  CAS  Google Scholar 

  26. Zheng Z., Zhang T. F., Liu H. X., Chen Y. C., Kwok R. T. K., Ma C., Zhang P. F., Sung H. H. Y., Williams I. D., Lam J. W. Y., Wong K. S., Tang B. Z., ACS Nano, 2018, 12, 8145

    Article  CAS  Google Scholar 

  27. Wang D., Su H., Kwok R. T. K., Hu X., Zou H., Luo Q., Lee M. M. S., Xu W., Lam J. W. Y., Tang B. Z., Chem. Sci., 2018, 9, 3685

    Article  CAS  Google Scholar 

  28. Cheng Y., Li G., Liu Y., Shi Y., Gao G., Wu D., Lan J., You J., J. Am. Chem. Soc., 2016, 138, 4730

    Article  CAS  Google Scholar 

  29. Chen X., Zhong Z., Xu Z., Chen L., Wang Y., Free Radical Res., 2010, 44, 587

    Article  CAS  Google Scholar 

  30. Wardman P., Free Radical Biol. Med., 2007, 43, 995

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China(Nos.22077038, 21702070), the Postdoctoral Research Foundation of China(No.2017M612461) and the Huazhong University Startup Fund of China.

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Authors and Affiliations

  1. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

    Fang Fang, Yuting Gao & Liang Luo

  2. Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

    Liang Luo

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  1. Fang Fang
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  2. Yuting Gao
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  3. Liang Luo
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Correspondence to Liang Luo.

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Fang, F., Gao, Y. & Luo, L. Mitochondrion-anchoring AIEgen with Large Stokes Shift for Imaging-guided Photodynamic Therapy. Chem. Res. Chin. Univ. 37, 137–142 (2021). https://doi.org/10.1007/s40242-021-0379-0

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  • DOI: https://doi.org/10.1007/s40242-021-0379-0

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