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Total synthesis and biological evaluation of Wewakazole

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Abstract

The total synthesis of Wewakazole was achieved on a gram scale, unambiguously confirming its structure. Three different substituted oxazoles present in this natural product were prepared efficiently. Biological evaluation indicated that Wewakazole significantly inhibited cancer cell proliferation in a dose-dependent manner.

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Authors and Affiliations

  1. The Fourth People’s Hospital of Shenzhen, Shenzhen, 518033, P. R. China

    Bohua Long & Zhengzhi Wu

  2. Shenzhen Institute of Geriatrics, Shenzhen, 518020, P. R. China

    Bohua Long & Zhengzhi Wu

  3. The Second People’s Hospital of Shenzhen, Shenzhen, 518035, P. R. China

    Bohua Long & Zhengzhi Wu

  4. Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, P. R. China

    Jingzhao Zhang, Xueyan Wang & Xudong Tang

Authors
  1. Bohua Long
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  2. Jingzhao Zhang
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  3. Xueyan Wang
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  4. Xudong Tang
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  5. Zhengzhi Wu
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Corresponding author

Correspondence to Bohua Long.

Additional information

Support by the Health and Family Planning Commission of Shenzhen Municipality, China(No.201601053) and the Basic Research Project of Shenzhen Science and Technology Plan, China(No.JCYJ20160428110124165).

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Long, B., Zhang, J., Wang, X. et al. Total synthesis and biological evaluation of Wewakazole. Chem. Res. Chin. Univ. 33, 890–894 (2017). https://doi.org/10.1007/s40242-017-7129-3

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  • DOI: https://doi.org/10.1007/s40242-017-7129-3

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