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Facile synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl) acetamide derivatives

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Chemical Research in Chinese Universities Aims and scope

Abstract

A facile and highly efficient method has been developed for the synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl)acetamide derivatives by regioselective Friedel-Crafts alkylation of the N-aryl-2-hydroxy-2-(1H-indol-3-yl) acetamide derivatives with various indoles catalyzed by 2 mol/L H2SO4 at room temperature in a short reaction time, the yield was up to 94%.

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Authors and Affiliations

  1. Key Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China

    Yan Zhou, Renjun Li, Xiaolong Wang & Yong Wu

  2. Department of Medicinal Chemistry and Key Laboratory of Drug Targeting of Education Ministry of China, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China

    Ling He

  3. West China Hospital, Sichuan University, Chengdu, 610041, P. R. China

    Mei Guan

Authors
  1. Yan Zhou
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  2. Renjun Li
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  3. Xiaolong Wang
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  4. Ling He
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  5. Mei Guan
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  6. Yong Wu
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Corresponding author

Correspondence to Yong Wu.

Additional information

Supported by the National Natural Science Foundation of China(No.81573286).

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Zhou, Y., Li, R., Wang, X. et al. Facile synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl) acetamide derivatives. Chem. Res. Chin. Univ. 32, 959–966 (2016). https://doi.org/10.1007/s40242-016-6233-0

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  • DOI: https://doi.org/10.1007/s40242-016-6233-0

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