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Aerobic alcohol ammoxidation catalyzed by copper(I)/amino acid: a scalable protocol to nitriles

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Abstract

A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles is developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide(CuI) as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates, even the substrates bearing oxidation-sensitive groups such as MeS—, alkenyl and —NH2 can also work well. In addition, the protocol is readily scaled up to more than 20 g and the product can be obtained just through filtration or distillation without conventional column chromatography.

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Authors and Affiliations

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China

    Guofu Zhang, Guihua Zhang, Jie Lei, Shasha Li, Shengjun Xu, Chengrong Ding & Shang Shan

Authors
  1. Guofu Zhang
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  2. Guihua Zhang
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  3. Jie Lei
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  4. Shasha Li
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  5. Shengjun Xu
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  6. Chengrong Ding
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  7. Shang Shan
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Corresponding authors

Correspondence to Chengrong Ding or Shang Shan.

Additional information

Supported by the National Natural Science Foundation of China(No.20702051) and the Natural Science Foundation of Zhejiang Province, China(No.LY13B020017).

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Zhang, G., Zhang, G., Lei, J. et al. Aerobic alcohol ammoxidation catalyzed by copper(I)/amino acid: a scalable protocol to nitriles. Chem. Res. Chin. Univ. 32, 586–593 (2016). https://doi.org/10.1007/s40242-016-6067-9

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  • DOI: https://doi.org/10.1007/s40242-016-6067-9

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