Abstract
Interaction between AmB and cell membrane is influenced by different metal cations. In the presence of K+, Na+ or Ca2+ ions, the surface pressure-area isotherms and the elastic modulus of an amphotericin-dipalmitoyl-phosphatidylcholine(AmB-DPPC) mixed monolayer were discussed. And the excess free energy and entropies of mixing were calculated according to the surface pressure-area isotherms. The phase transition of the mixed monolayer needed a higher concentration of AmB in the sequence Na+>pure buffer>K+>Ca2+. When the molar fraction of AmB(x AmB) was 0.5, the molecular interaction changed from attraction to repulsion and the mixed monolayer turned to ordered state from disorder state under the induction of K+ or Ca2+ ions at all surface pressure in our experiment. At high surface pressure, the disorder of monolayer enhanced in the presence of Na+ ions at x AmB>0.1. At different molar ratios of AmB, the influences of these metal cations were discrepant. These cations may influence AmB molecules to form pores on the monolayer. It is helpful to understand the reduction of AmB’s toxicity as theoretical reference.
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References
Martin J. F., Annu. Rev. Microbiol, 1977, 31, 13
Dynarowicz-Latka P., Minoes J., Conde O., Casas M., Iribarnegaray E., Appl. Surf. Sci., 2005, 246, 334
Janoff A. S., Boni L. T., Popescu M. C., Minchey S. R., Cullis P. R., Madden T. D., Taraschi T., Gruner S. M., Shyamsunder E., Tate M. W., Proc. Natl. Acad. Sci. USA, 1988, 85, 6122
Brajtburg J., Powderly W. G., Kobayashi G. S., Medoff G., Antimicrob. Agents Chemother., 1990, 34, 182
Clark A. M., Ed.: Ferandes P., the Need for New Antifungal Drugs, in New Approaches to Antifungal Drugs, Birkhauser, Boston, 1992, 1
Becucci L., Innocenti M., Bellandi S., Guidelli R., Electrochimica Acta, 2013, 112, 719
Dekruijf B., Demel R. A., Biochim. Biophys. Acta., 1974, 339, 57
Lampen J. O., Arrow P. M., Safferman R. S., J. Bacteriol., 1960, 80, 200
Ganrrignes J. C., Ricco-Lattes I., Perez E., Lattes A., Langmuir, 1998, 14, 5968
Holtz R., Filkenstein A., J. Gen. Physiol., 1970, 56, 125
Ermishkin L. N., Kasumov Kh-M., Potzeluyev V. M., Nature, 1976, 262, 698
Andreoli T. E., Ann. N. Y. Acad. Sci., 1974, 235, 448
Hac-Wydro K., Dynarowicz-Latka P., Grzybowska J., Borowski E., Colloids Surf. B Biointerfaces, 2005, 46, 7
Gruda I., Nadeau P., Brajtburg J., Medoff G., Biochim. Biophys. Acta, 1980, 602, 260
Katsu T., Okada S., Imamura T., Komagoe K., Masuda K., Inoue T., Nakao S., Anal. Sci., 2008, 24, 1551
Kasai Y., Matsumori N., Umegawa Y., Matsuoka S., Ueno H., Ikeuchi H., Oishi T., Murata M., Chemistyr., 2008, 14, 1178
Hartsel S. C., Benz S. K., Peterson R. P., White B. S., Biochem., 1991, 30, 77
Brajtburg J., Bolard J., Clin. Microbiol. Rev., 1996, 9, 512
Turcu R., Patterson M. J., Omar S., Pediatr. Nephrol., 2009, 24, 497
Brajtburg J., Medoff G., Kobayashi G., Elberg S., Antimicrob. Agents Chemother., 1980, 18, 593
Gagos M., Arczewska M., J. Phys. Chem. B, 2011, 115, 3185
Gagos M., Arczewska M., Gruszecki W. I., J. Phys. Chem. B, 2011
Han X., Hao C. C., Sun R. G., Acta Biophysica Sinica, 2007, 23(6), 448
Li Y., Liu Z. C., Journal of Biomedical Engineering, 2011, 2(2), 296
Levy M. N., Stanton B. A., Koeppen B. M., Translators: Mei Y. N., Wang J. J., Berne and Levy Principles of Physiology, Higher Education Press, Beijing, China, 2008, 63–443
Zhang J. F., Huminal Phsiology, Higher Education Press, Beijing, 2008, 57
Zakanda F. N., Laurent P., Paquot M., Lelo G. M., Deleu M., Thin Solid Films, 2011, 520, 344
Nakahara H., Nakamura S., Okahashi Y., Kitaguchi D., Kawabata N., Sakamoto S., Shibata O., Colloids Surf. B Biointerfaces, 2013, 102, 472
Panda A. K., Wojciechowski P., Nag S., Possmayer F., Petersen N. O., J. Disp. Sci. Technol., 2009, 30, 1255
Jurak M., Chem. Phys. Lipids, 2014, 183, 60
Costin L. S., Barnes G. T., J.Colloid Interface Sci., 1975, 51, 106
Birdi K. S., Lipid and Biopolymer Monolayers at Liquid Interfaces, Plenum Press, New York, 1989
Goodrich F. C., Ed.: Schulman J. H., Proceedings of the Second International Congress of Surface Activity, Vol.1, Butterworth, London. 1957, 85
Tancrede P., Munger G., Leblanc R. M., Biochimica et Biophysica Acta(BBA)-Biomembranes, 1982, 689, 45
Hao C. C., Zhang L., Sun R. G., Zhang J., He G. X., Yang J., Chem. J. Chinese Universities, 2013, 34(10), 2340
Gzyl-Malcher B., Handzlik J., Klekowska E., Bioelectrochem., 2012, 87, 96
Dynarowicz-Latka P., Kita K., Adv. Colloid Interface Sci., 1999, 79, 1
Sykora J. C., Neely W. C., Vodyanoy V., J. Colloid Interface Sci., 2004, 276, 60
Hac-Wydro K., Dynarowicz-Latka P., Grzybowska J., Borowski E., Biophys. Chem., 2005, 116, 77
Gagos M., Arczewska M., Biochim. Biophys. Acta, 2010, 1798, 2124
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Supported by the Foundamental Research Funds for the Central Universities, China(No.GK201504004).
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Wang, J., Sun, R. & Li, J. Influence of K+, Na+ or Ca2+ ions on the interaction between AmB and saturated phospholipids by Langmuir technique. Chem. Res. Chin. Univ. 32, 242–247 (2016). https://doi.org/10.1007/s40242-016-5410-5
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DOI: https://doi.org/10.1007/s40242-016-5410-5