Abstract
The Mannich reaction of various 5-substituted and N-acyl substituted chiral hydantoins with a series of aldimines smoothly occurred with full stereochemical control. These Mannich adducts have been cleaved by alcoholysis to afford several synthetically useful chiral building blocks like β-amino esters and β-lactams in good yields and in enantiopure form.
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Supported by the National Natural Science Foundation of China(No.21342002).
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Chen, F., Lu, C., Nie, J. et al. Scope and limitations of optical pure hydantoins as chiral auxiliaries in asymmetric Mannich reactions. Chem. Res. Chin. Univ. 32, 219–225 (2016). https://doi.org/10.1007/s40242-016-5273-9
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DOI: https://doi.org/10.1007/s40242-016-5273-9