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The global scientific publications on gut microbiota in type 2 diabetes; a bibliometric, Scientometric, and descriptive analysis

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Journal of Diabetes & Metabolic Disorders Aims and scope Submit manuscript

Abstract

Background

Modifying gut dysbiosis has achieved great success in managing type 2 diabetes mellitus (T2DM) and also T2DM affected the gut microbial composition.

Objectives

To determine the research trend of scientific publications on the relationship between gut microbiota and T2DM through a bibliometric and descriptive approach.

Method

We included originals and reviews related to both topics of gut microbiota and T2DM through searching in Scopus up to 31 December 2019 and then characterized their bibliometric profiles including the number of publications, citations, institutions, journals, countries, and the collaboration network of authors, countries, terms and keywords. Moreover, we performed a descriptive evaluation of the clinical trials based on their intervention type and its influence on gut dysbiosis.

Results

We achieved 877 articles (436 originals and 441 reviews) according to our inclusion criteria. The annual publications were constantly increased over time and reached 220 publications in 2019. Out of 436 original articles, 231 animal studies and 174 human studies were found. The majority of human studies were clinical trials (n = 77) investigating the influence of drugs (n = 21), regimens (n = 21), pre/pro/symbiotic (n = 19), surgeries (n = 15), or both drug and regimen (n = 1) on gut dysbiosis. Roux-en-Y gastric bypass and metformin were assessed the most in these trials. Obesity side by side T2DM has been assessed in this area of literature based on term and keyword analyses showing their possible similar pathways mediated by gut microbiota.

Conclusion

The exponentially growing documents on gut microbiota and T2DM had been published during the last decade and revealed gut microbiota alteration mediated antidiabetic effect of many interventions. Thus, we suggest other researchers to consider this pathway in efficacy assessment of therapeutic modalities and to find the optimal composition of gut microbiota that guarantees healthy insulin sensitivity.

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Data availability

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Abbreviations

T2DM:

Type 2 diabetes mellitus

U.S.:

United States

USA:

United States of America

NIH:

National Institutes of Health

WOS:

Web of Science

RYGB:

Roux-en-Y Gastric Bypass

SCFA:

Short-chain fatty acids

GLP-1:

Glucagon-like peptide-1

FFAR2:

Free fatty acid receptor 2

FFAR3:

Free fatty acid receptor 3

NGS:

Next-generation sequencing

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hojat Dehghanbanadaki, Hanieh Sadat Ejtahed & Ozra Tabatabaei-Malazy

  2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hossein Aazami

  3. Scientometrics Department, FarIdea Company, Tehran, Iran

    Hossein Aazami

  4. Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran

    Ahmad Sohrabi

  5. Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran

    Shahrbanoo Keshavarz Azizi Raftar, Samira Tarashi & Seyed Davar Siadat

  6. Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran

    Shahrbanoo Keshavarz Azizi Raftar, Samira Tarashi & Seyed Davar Siadat

  7. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Ozra Tabatabaei-Malazy

  8. Hepatitis, AIDS and Bloodborne Diseases Department, Pasteur Institute of Iran, Tehran, Iran

    Golnaz Bahramali

  9. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Ensieh Nasli Esfahani & Farideh Razi

Authors
  1. Hojat Dehghanbanadaki
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  2. Hossein Aazami
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  3. Hanieh Sadat Ejtahed
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  9. Seyed Davar Siadat
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  10. Ensieh Nasli Esfahani
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  11. Farideh Razi
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Contributions

H.A, H.D and F.R formed the idea of the study; H.A designed the protocol of the study; H.A, H.D, F.R, S.T, HS.E and SKA.R scanned the literature for data collection; H.A, G.B, EN.E and F.R analyzed and interpreted the data; H.A and H.D provided the draft of the manuscript and SD.S, G.B, HS.E and F.R revised the manuscript focused on the intellectual content.

Corresponding author

Correspondence to Farideh Razi.

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Ethics approval and consent to participate

Since the current study is based on the bibliometric analysis of the previous studies, there is no need for ethical approval or participant consent.

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Not applicable.

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The authors declare that they have no conflict of interest.

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Supplementary Information

Supplementary Figure S1

The yearly citation numbers of published articles in the field of gut microbiota and type 2 diabetes (PNG 243 KB)

Supplementary Figure S2

Cluster mapping of terms with at least 30 occurrences in the titles and abstracts of gut microbiota and type 2 diabetes articles (PNG 79.1 MB)

Supplementary Figure S3

Cluster mapping of co-authorship network between authors with minimum of 10 articles on gut microbiota and type 2 diabetes (PNG 15.5 MB)

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Dehghanbanadaki, H., Aazami, H., Ejtahed, H.S. et al. The global scientific publications on gut microbiota in type 2 diabetes; a bibliometric, Scientometric, and descriptive analysis. J Diabetes Metab Disord 21, 13–32 (2022). https://doi.org/10.1007/s40200-021-00920-1

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