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The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials

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Abstract

Purpose

Selenium (Se) is a trace element having significant effects on human metabolism. Recent studies suggest that Se supplementation have a pivotal effect on the inflammatory markers. Therefore, the aim of this study was to assess the effect of Se supplementation on plasma inflammatory markers including C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) and nitric oxide (NO) as a stress oxidative index, among patients with metabolic diseases.

Methods

To assess the effects of Se on the inflammatory markers, following the PRISMA-P guidelines, we systematically searched ISI/WOS, PubMed/MEDLINE, and Scopus for studies that assessed the effect of Se supplementation on the inflammatory markers. Data extraction was performed by two independent investigators. Using the random effects or fixed-effects model depending on the results of heterogeneity tests was used to estimate the pooled standardized mean difference (SMD). Heterogeneity between studies was assessed using Cochran's Q test and I2 index.

Results

The initial search revealed 3,320 papers. After screening process and considering inclusion criteria, 7 publications were eligible for inclusion in the meta-analysis. The meta-analysis results showed that Se supplementation did not significantly affect CRP and hs-CRP concentrations (mean difference (MD) = -0.15; 95% CI: -0.55- 0.23; P = 0.43). Subgroup analysis of CRP type showed that Se supplementation significantly decreased hs-CRP level (pooled SMD = -0.44; 95% CI: -0.67–0.21). Moreover, no significant change was observed in NO level by continuing to take Se supplementation, (pooled SMD: 0.003, 95%CI: -0.26, 0.26).

Conclusions

This study revealed that Se supplementation would have desirable effects on cardio-metabolic indicators through affecting the levels of inflammatory markers. Given the importance of concerns, more attention should be given to more prospective studies with longer follow-up.

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Data availability

The dataset supporting the conclusions of this article is included within the article.

Abbreviations

SMD:

Standardized mean difference

CI:

Confidence interval

Se:

Mineral selenium

CRP:

C-reactive protein

IL:

Interleukins

TNFα:

Tumor necrosis factor-α

RCTs:

Randomized control trials

PCOS:

Polycystic ovary syndrome

GDM:

Gestational Diabetes

CHD:

Coronary heart disease

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Acknowledgements

The authors are thankful of the team working on this study and all participants who made this experience.

Funding

This study was funded by the Alborz University of Medical Sciences.

Author information

Authors and Affiliations

  1. Development of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran

    Shirin Djalalinia

  2. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran Universityof Medical Sciences, Tehran, Iran

    Shirin Djalalinia

  3. School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Motahareh Hasani

  4. Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran

    Hamid Asayesh

  5. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hanieh-Sadat Ejtahed & Hanieh Malmir

  6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hanieh-Sadat Ejtahed

  7. Hematology-Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran

    Amir Kasaeian

  8. Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Amir Kasaeian

  9. Department of Nutrition and Dietetics Faculty of Medicine and Health Sciences , University Putra Malaysia , Selangor, Serdang, Malaysia

    Maryam Zarei

  10. Centre of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark

    Fereshteh Baygi

  11. Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran

    Hadith Rastad

  12. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

    Hadith Rastad & Mostafa Qorbani

  13. Social Determinants of Health Research Center Alborz, University of Medical Sciences , Karaj, Iran

    Armita Mahdavi Gorabi

Authors
  1. Shirin Djalalinia
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  2. Motahareh Hasani
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  3. Hamid Asayesh
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  4. Hanieh-Sadat Ejtahed
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  5. Hanieh Malmir
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  6. Amir Kasaeian
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  7. Maryam Zarei
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  8. Fereshteh Baygi
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  9. Hadith Rastad
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  10. Armita Mahdavi Gorabi
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  11. Mostafa Qorbani
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Contributions

The concept of this study was proposed by S.D., M.Q., This study was designed S.D., M.Q., M.H., Data extraction was done by H.A., H.-S.E., A.K., M.Z., F.B., H.R., A.M.G., Analysis or interpretation was performed by M.Q., S.D, Literature search was done by S.D. This study was written by S.D., M.Q. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mostafa Qorbani.

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The authors declare no conflicts of interest.

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Djalalinia, S., Hasani, M., Asayesh, H. et al. The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord 20, 1051–1062 (2021). https://doi.org/10.1007/s40200-021-00821-3

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  • DOI: https://doi.org/10.1007/s40200-021-00821-3

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