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Effect of pre-meal water intake on the serum levels of Copeptin, glycemic control, lipid profile and anthropometric indices in patients with type 2 diabetes mellitus: a randomized, controlled trial

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Abstract

Background

Water pre-load affects insulin secretion by altering the level of copeptin (C-terminal component of the arginine vasopressin hormone (AVP)) and preventing obesity by reducing food intake.

Aims

The present randomized controlled trial (RCT) aimed to investigate the effects of pre-meal water intake on type 2 diabetes Mellitus (T2DM).

Materials and methods

In this study, 40 patients with T2DM were randomly assigned to two intervention groups for 8 weeks; a) drinking 1 liter of water per day before each main meal (PW group)., and b) no water consumption before any meal (NPW group). At the beginning and at the end of the study, blood samples were taken to assess glycemic indices, lipid profile, copeptin and anthropometric indices.

Results

Pre-meal water intake was associated with lower energy intake, BMI, waist circumference (WC) and greater weight loss, in compared with the controls (P < 0.0001) after 8 weeks. At the end of the trial, the concentrations of fasting blood sugar (FBS) (P < 0.0001), triglyceride (TG) (P < 0.05), low-density lipoprotein cholesterol (LDL-C) (P < 0.05) and copeptin (P < 0.05) were significantly reduced following water drinking before meals.

Conclusion

To sum up, the present study revealed that pre-meal water intake is associated with lower BMI, body weight, WC, FBS, TG, LDL-C and copeptin levels in patients with T2DM.

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Acknowledgements

This article was extracted from a master’s degree thesis in nutrition. The authors are grateful to Research Vice Chancellor of Zahedan University of Medical Sciences for financial support and to all patients for their sincere cooperation to this study.

Funding

Research Deputy of Zahedan University of Medical Sciences, Zahedan, Iran financially supported the present study (grant No. 8984).

Author information

Authors and Affiliations

  1. Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Gohar Sedaghat & Shadi Shourestani

  2. Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Farzaneh Montazerifar

  3. Genetics of Non-Communicable Disease Research Center, Department of Internal, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Mahmood Ali Keykhaie

  4. Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Mansour Karajibani

  5. Cellular and Molecular Research Center, Department of Food and Technology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Alireza Dashipour

Authors
  1. Gohar Sedaghat
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  5. Shadi Shourestani
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Contributions

FM and GS contributed to study design and concept. MAK visited patients. GS and SS contributed to data collection. FM and AD contributed to data analyses. FM, GS, MK and MAK contributed to drafting and reviewing the final manuscript. All authors read and approved the final manuscript for publication.

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Correspondence to Farzaneh Montazerifar.

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Sedaghat, G., Montazerifar, F., Keykhaie, M.A. et al. Effect of pre-meal water intake on the serum levels of Copeptin, glycemic control, lipid profile and anthropometric indices in patients with type 2 diabetes mellitus: a randomized, controlled trial. J Diabetes Metab Disord 20, 171–177 (2021). https://doi.org/10.1007/s40200-020-00724-9

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  • DOI: https://doi.org/10.1007/s40200-020-00724-9

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