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Chromium Supplementation; Negotiation with Diabetes Mellitus, Hyperlipidemia and Depression

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Abstract

Chromium (Cr) is an essential trace element which found naturally in a daily diet and available in the form of supplementary tablets to boost disorders like diabetes mellitus (DM) and functions like lipid metabolism and beneficial on depression too. Diabetes is one of the most prevalent endocrine diseases or in other words, the most severe metabolic syndrome (MS), which associated with high production of free-radicals which is out of bodies detoxifying machine capacity or high oxidative stress (HOS), vasculitis and elevated lipid profile. many research papers and clinical trials published about the significance of chromium on biological activities, pre and post clinical. For this review research articles, clinical trials, from 1st Jan’10 to 31st Dec’18 and refer literature for the biochemical, pharmacological and biological activity of Chromium. Primarily articles gathered from the above search engines. Then precisely according to our aim and goal and regarding designed objectives dismisses similar articles and finally came to 84 articles for the above said period. This review trying to cover the entire picture from what chromium is to the recent updates on their greater role in increasing insulin sensitivity of cells and enhancing lipid metabolism and even recent findings suggest its positive effects including prevention and ameliorating properties on depression. The biological activities, pharmacological features, clinical implications including efficacy and role of chromium compounds on the glycaemic index will be discussed. The outcome of this review is to bring the pros and cons of chromium supplementation along with is safety and toxicity concern beside molecular pathways, biochemistry and clinical trials, all in one comprehensive review.

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Acknowledgment

This research/review did not receive any special grant from funding agencies in the public, commercial or not-for-sale sector. The authors of this paper thank members of Sciences faculty of the University of Zabol, especially Dr. Nima Sanadgol, and alumni including Fahimeh Javadi H., Rezvan Bagheri and Roghayyeh Amiz.

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  1. Division of Human Genetics, Department of Anatomy, St. john’s hospital, Bangalore, India

    Amir Khodavirdipour

  2. Department of Biology, Faculty of Natural sciences, University of Tabriz, Tabriz, 98613-35856, Iran

    Amir Khodavirdipour

  3. Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran

    Fatemeh Haddadi & Shiva Keshavarzi

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  1. Amir Khodavirdipour
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Khodavirdipour, A., Haddadi, F. & Keshavarzi, S. Chromium Supplementation; Negotiation with Diabetes Mellitus, Hyperlipidemia and Depression. J Diabetes Metab Disord 19, 585–595 (2020). https://doi.org/10.1007/s40200-020-00501-8

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