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Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different atomization temperatures: physicochemical characterization and technological development for pharmaceutical applications

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Abstract

Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia pellucida L. (HBK) by spray drying. The characterization of the extract was performed by thermal analysis, specific surface area, particle size and high performance liquid chromatography (HPLC); then, capsules were developed for antimicrobial treatment, evaluating four bench lots by the determination of the angle of repose and time of flow, scanning electron microscopy, porosity and physicochemical quality control. There were no significant differences between the extracts obtained by spray drying at atomization temperatures of 140 °C, 160 °C and 180 °C, which was confirmed by thermal analysis. Specific surface area varied inversely with the mean particle size. Regarding the marker content by HPLC, no significant differences were found between the samples, although the flavonoid fraction was more stable at 160 °C. Bench lots (I to IV) were developed using the diluents Flowlac®, Starch® 1500, microcrystalline cellulose 250 and Cellactose® 80. Based on the results, the bench lot I, containing Flowlac®, was selected. The results of physicochemical quality control demonstrated that the selected formulation meets the pre-established parameters, and proving to be economically viable.

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The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Authors and Affiliations

  1. Laboratório de Tecnologia dos Medicamentos, Pharmacy Department, Federal University of Pernambuco, Cidade Universitária, Av. Prof. Arthur de Sá, S/N, CEP: 50740-525, Recife, Pernambuco, Brazil

    Rosali Maria Ferreira da Silva, Thays Cristiane Barbosa Lucena Gomes, Williana Tôrres Vilela, Pollyne Amorim Silva, Victor de Albuquerque Wanderley Sales, Keyla Emmanuelle Ramos da Silva, Salvana Priscylla Manso Costa & Pedro José Rolim Neto

  2. Laboratory of Microscopy, Center for Strategic Technologies of the Northeast, Recife, PE, Brazil

    Adriana Fernandes Campos

  3. Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada

    Giovanna Christinne Rocha de Medeiros Schver

  4. Laboratory of Quality Control of Pharmaceutical Products, Federal University of Paraíba, João Pessoa, PB, Brazil

    Fábio Santos de Souza

  5. Department of Chemistry, Federal University of Pará, Belém, PA, Brazil

    Manolo Cleiton Costa de Freitas, Mara Sílvia Pinheiro Arruda & Milton Nascimento da Silva

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  1. Rosali Maria Ferreira da Silva
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da Silva, R.M.F., Gomes, T.C.B.L., Campos, A.F. et al. Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different atomization temperatures: physicochemical characterization and technological development for pharmaceutical applications. DARU J Pharm Sci 29, 147–158 (2021). https://doi.org/10.1007/s40199-021-00393-w

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