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Spine Disorders and Regenerative Rehabilitation

  • Regenerative Rehabilitation (CM Terzic, Section Editor)
  • Published:
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Abstract

Purpose of Review

The purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders.

Recent Findings

Immunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis.

Summary

While current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.

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Authors and Affiliations

  1. Department of Physical Medicine & Rehabilitation, Mayo Clinic, Mayo Building, Rm 14-03, 200 1st ST, SW, Rochester, MN, 55905, USA

    Eva Kubrova & Wenchun Qu

  2. Department of Orthopedic Surgery, Mayo Clinic, Medical Sciences Building, Rm S3-69, 200 1st ST, SW, Rochester, MN, 55905, USA

    Eva Kubrova & Andre J. van Wijnen

  3. Department of Biochemistry & Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA

    Andre J. van Wijnen

  4. Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA

    Wenchun Qu

  5. Spine Center, Mayo Clinic, Rochester, MN, USA

    Wenchun Qu

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  1. Eva Kubrova
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Kubrova, E., van Wijnen, A.J. & Qu, W. Spine Disorders and Regenerative Rehabilitation. Curr Phys Med Rehabil Rep 8, 30–36 (2020). https://doi.org/10.1007/s40141-019-00252-5

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