Abstract
Purpose of the Review
Surgical site infections (SSI) affect millions of individuals around the world, leading to a significant burden on perioperative morbidity and healthcare economy. Over the past decade low-income and middle-income countries (LMICs) have made substantial advancements on infection prevention strategies. However, the incidence of SSI is still increasing in many LMICs across all surgical specialties, denoting overlooked areas and ongoing challenges. This article aims to describe the role of anesthesiologists on current standards of infection prevention and sterility as well as ongoing developments in resource-limited settings, with a focus on LMICs.
Recent Findings
Recent estimates indicate a threefold increase in the incidence of SSI across LMICs over the past two decades, approaching two times the estimated SSI incidence of high-income countries. As a result, public health officials have promoted standard practices for infection prevention in the surgical arena by creating multidisciplinary teams and tailoring to the availability of equipment and resources. Anesthesiologists play a pivotal role for the implementation of infection prevention strategies such as antimicrobial prophylaxis, normothermia, intraoperative glucose control, and adequate handling of intravenous anesthetics. Unfortunately, the lack of cohesive practices and leadership structures, along with poor surveillance systems, are still common barriers. One potential method of overcoming these obstacles is investment in sustainable national infection prevention programs.
Summary
Infection prevention standards should be tailored to local workflow and institutional resources. The successful implementation of programs in LMICs depends on sustainable national infection prevention programs which includes a well-trained team and an institutional climate of safety.
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References
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Berrios-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152:784–91. https://doi.org/10.1001/jamasurg.2017.0904.
Rickard J, Beilman G, Forrester J, Sawyer R, Stephen A, Weiser TG, et al. Surgical infections in low- and middle-income countries: a global assessment of the burden and management needs. Surg Infect. 2020;21:478–94. https://doi.org/10.1089/sur.2019.142.
Biccard BM, Madiba TE, Kluyts H-L, Munlemvo DM, Madzimbamuto FD, Basenero A, et al. Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet. 2018;391:1589–98.
Pittet D, Allegranzi B, Storr J, Bagheri Nejad S, Dziekan G, Leotsakos A, et al. Infection control as a major World Health Organization priority for developing countries. J Hosp Infect. 2008;68:285–92. https://doi.org/10.1016/j.jhin.2007.12.013.
•• GlobalSurg C. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis. 2018;18:516–25. https://doi.org/10.1016/S1473-3099(18)30101-4This is the largest cohort study evaluating the epidemiology of surgical site infection in LMICs, including trends and risk factors in geographic areas with the highest incidence of infections. The authors highlight the significant burden of surgical site infection and its relationship with healthcare disparities.
Jepsen OB, Jensen LP, Zimakoff J, Friis H, Bissoonauthsing CN, Kasenally AT, et al. Prevalence of infections and use of antibiotics among hospitalized patients in Mauritius. A nationwide survey for the planning of a national infection control programme. J Hosp Infect. 1993;25:271–8.
Surgery NI, for HRGRHU on G, Nepogodiev D, Adisa A, Abantanga FA, Ademuyiwa A, et al. Delphi prioritization and development of global surgery guidelines for the prevention of surgical-site infection. Br J Surg 2020;107(8):970–77.
Yezli S, Barbut F, Otter JA. Surface contamination in operating rooms: a risk for transmission of pathogens? Surg Infect (Larchmt). 2014;15:694–9.
Leaper DJ, Edmiston CE. World Health Organization: global guidelines for the prevention of surgical site infection. J Hosp Infect. 2017;95:135–6. https://doi.org/10.1016/j.jhin.2016.12.016.
Rutala WA, Weber DJ. Guideline for disinfection and sterilization in healthcare facilities, 2008. 2008.
O’Hara NN, Patel KR, Caldwell A, Shone S, Bryce EA. Sterile reprocessing of surgical instruments in low-and middle-income countries: a multicenter pilot study. Am J Infect Control. 2015;43:1197–200.
Link T. Guideline implementation: manual chemical high-level disinfection: 1.5 www. aornjournal. org/content/cme. AORN J. 2018;108:399–410.
Zorrilla-Vaca A, Escandón-Vargas K, Brand-Giraldo V, Leon T, Herrera M, Payan A. Bacterial contamination of propofol vials used in operating rooms of a third-level hospital. Am J Infect Control. 2015;In-press:e1–3.
Zorrilla-Vaca A, Escandón-Vargas K. The importance of infection control and prevention in anesthesiology. Rev Colomb Anestesiol. 2017;45:69.
• Zorrilla-Vaca A, Arevalo J, Escandón-Vargas K, Soltanifar D, Mirski M. Infectious diseases risk and propofol anesthesia, 1989–2014. Emerg Infect Dis 2016; 22(6)981–92. The authors compiled all the anesthesia-associated outbreaks related to contaminated propofol administration. The most common causes of the outbreaks are the reuse of syringes in low resource settings, use of single-dose vials for multiple patients and inadequate aseptic technique.
Section IV Implementation Manual for the World Health Organization Surgical Safety Checklist. In: WHO guidelines for safe surgery 2009: safe surgery saves lives. Geneva; 2009. https://www.ncbi.nlm.nih.gov/pubmed/23762968.
Boyce JM. Current issues in hand hygiene. Am J Infect Control. 2019;47:A46–52.
Omuemu VO, Ogboghodo EO, Opene RA, Oriarewo P, Onibere O. Hand hygiene practices among doctors in a tertiary health facility in southern Nigeria. J Med Trop. 2013;15:96.
Gon G, de Bruin M, de Barra M, Ali SM, Campbell OM, Graham WJ, et al. Hands washing, glove use, and avoiding recontamination before aseptic procedures at birth: a multicenter time-and-motion study conducted in Zanzibar. Am J Infect Control. 2019;47:149–56.
Ataiyero Y, Dyson J, Graham M. Barriers to hand hygiene practices among health care workers in sub-Saharan African countries: a narrative review. Am J Infect Control. 2019;47:565–73.
Lindsjo C, Sharma M, Mahadik VK, Sharma S, Stalsby Lundborg C, Pathak A. Surgical site infections, occurrence, and risk factors, before and after an alcohol-based handrub intervention in a general surgical department in a rural hospital in Ujjain, India. Am J Infect Control. 2015;43:1184–9. https://doi.org/10.1016/j.ajic.2015.06.010.
Kampf G, Kramer A. Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs. Clin Microbiol Rev. 2004;17:863–93.
Parienti JJ, Thibon P, Heller R, Le Roux Y, von Theobald P, Bensadoun H, et al. Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study. Jama. 2002;288:722–7.
Nthumba PM, Stepita-Poenaru E, Poenaru D, Bird P, Allegranzi B, Pittet D, et al. Cluster-randomized, crossover trial of the efficacy of plain soap and water versus alcohol-based rub for surgical hand preparation in a rural hospital in Kenya. Br J Surg. 2010;97:1621–8. https://doi.org/10.1002/bjs.7213.
Reilly JS, Price L, Lang S, Robertson C, Cheater F, Skinner K, et al. A pragmatic randomized controlled trial of 6-step vs 3-step hand hygiene technique in acute hospital care in the United Kingdom. Infect Control Hosp Epidemiol. 2016;37:661–6.
Tschudin-Sutter S, Sepulcri D, Dangel M, Ulrich A, Frei R, Widmer AF. Simplifying the World Health Organization protocol: 3 steps versus 6 steps for performance of hand hygiene in a cluster-randomized trial. Clin Infect Dis. 2019;69:614–20.
Munoz-Price LS, Birnbach DJ. Hand hygiene and anesthesiology. Int Anesthesiol Clin. 2013;51:79–92. https://doi.org/10.1097/AIA.0b013e31826f2db6.
• Munoz-Price LS, Bowdle A, Johnston BL, Bearman G, Camins BC, Dellinger EP. et al., Infection prevention in the operating room anesthesia work area. Infect Control Hosp Epidemiol. 2018:1–17. https://doi.org/10.1017/ice.2018.303The authors updated the current guidelines for infection prevention in the anesthesia work area. In summary, anesthesiologists should comply with the 5-moments of hand hygiene in any procedure that involve contact with surfaces, avoid reusing of single-dose vials, and adopt adequate aseptic technique for any invasive procedure.
Sherman JD, Hopf HW. Balancing infection control and environmental protection as a matter of patient safety: the case of laryngoscope handles. Anesth Analg. 2018;127:576–9. https://doi.org/10.1213/ANE.0000000000002759.
Lowman W, Venter L, Scribante J. Bacterial contamination of re-usable laryngoscope blades during the course of daily anaesthetic practice. S Afr Med J. 2013;103:386–9. https://doi.org/10.7196/samj.6385.
Mitchell KF, Barker AK, Abad CL, Safdar N. Infection control at an urban hospital in Manila, Philippines: a systems engineering assessment of barriers and facilitators. Antimicrob Resist Infect Control. 2017;6:90.
Sherman JD, Raibley LA t, Eckelman MJ. Life cycle assessment and costing methods for device procurement: comparing reusable and single-use disposable laryngoscopes. Anesth Analg. 2018;127:434–43. https://doi.org/10.1213/ANE.0000000000002683.
Shohat N, Goswami K, Tarabichi M, Sterbis E, Tan TL, Parvizi J. All patients should be screened for diabetes before total joint arthroplasty. J Arthroplasty. 2018;33:2057–61.
Mueck KM, Kao LS. Patients at high-risk for surgical site infection. Surg Infect. 2017;18:440–6. https://doi.org/10.1089/sur.2017.058.
Van der Spuy K, Crowther M, Nejthardt M, Roodt F, Davids J, Roos J, et al. A multicentre, cross-sectional study investigating the prevalence of hypertensive disease in patients presenting for elective surgery in the Western Cape Province, Souht Africa. S Afr Med J. 2018;108:590–5. https://doi.org/10.7196/SAMJ.2018.v108i7.13022.
Biesman-Simons T, Conradie WS, Nejthardt M, Roodt F, Davids J, Pretorius T, et al. A multicentre prospective observational study of the prevalence and glycaemic control of diabetes mellitus in adult non-cardiac elective surgical patients in hospitals in Western Cape Province. South Africa. S Afr Med J. 2019;109:801–6. https://doi.org/10.7196/SAMJ.2019.v109i10.013898.
Muchuweti D, Jönsson KUG. Abdominal surgical site infections: a prospective study of determinant factors in Harare, Zimbabwe. Int Wound J. 2015;12:517–22.
Bordes J, Cungi P, Savoie P, Bonnet S, Kaiser E. Usefulness of routine preoperative testing in a developing country: a prospective study. Pan Afr Med J. 2015;21:94.
Decker BK, Nagrebetsky A, Lipsett PA, Wiener-Kronish JP, O’Grady NP. Controversies in perioperative antimicrobial prophylaxis. Anesthesiology. 2020;132:586–97. https://doi.org/10.1097/ALN.0000000000003075.
Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surg Infect. 2013;14:73–156. https://doi.org/10.1089/sur.2013.9999.
Van Dijck C, Vlieghe E, Cox JA. Antibiotic stewardship interventions in hospitals in low-and middle-income countries: a systematic review. Bull World Health Organ. 2018;96:266.
Al-Momany NH, Al-Bakri AG, Makahleh ZM, Wazaify MM. Adherence to international antimicrobial prophylaxis guidelines in cardiac surgery: a Jordanian study demonstrates need for quality improvement. J Manag Care Pharm. 2009;15:262–71. https://doi.org/10.18553/jmcp.2009.15.3.262.
Abubakar U, Syed Sulaiman SA, Adesiyun AG. Utilization of surgical antibiotic prophylaxis for obstetrics and gynaecology surgeries in Northern Nigeria. Int J Clin Pharm. 2018;40:1037–43. https://doi.org/10.1007/s11096-018-0702-0.
Saied T, Hafez SF, Kandeel A, El-Kholy A, Ismail G, Aboushady M, et al. Antimicrobial stewardship to optimize the use of antimicrobials for surgical prophylaxis in Egypt: a multicenter pilot intervention study. Am J Infect Control. 2015;43:e67–71.
Davey P, Brown E, Charani E, Fenelon L, Gould IM, Holmes A, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2017;9(2):CD003543.
Satti MZ, Hamza M, Sajid Z, Asif O, Ahmed H, Zaidi SMJ, et al. Compliance rate of surgical antimicrobial prophylaxis and its association with knowledge of guidelines among surgical residents in a tertiary care public hospital of a developing country. Cureus. 2019;11:e4776.
Olaoye O, Tuck C, Khor WP, McMenamin R, Hudson L, Northall M, et al. Improving access to antimicrobial prescribing guidelines in 4 African countries: development and pilot implementation of an app and cross-sectional assessment of attitudes and behaviour survey of healthcare workers and patients. Antibiotics. 2020;9:555.
Charani E, Smith I, Skodvin B, Perozziello A, Lucet JC, Lescure FX, et al. Investigating the cultural and contextual determinants of antimicrobial stewardship programmes across low-, middle- and high-income countries-a qualitative study. PLoS One. 2019;14:e0209847. https://doi.org/10.1371/journal.pone.0209847.
Thomas S, Palmer R, Phillipo E, Chipungu G. Reducing bacterial contamination in an orthopedic theatre ventilated by natural ventilation, in a developing country. J Infect Dev Ctries. 2016;10:518–22. https://doi.org/10.3855/jidc.7436.
Ackermann W, Fan Q, Parekh AJ, Stoicea N, Ryan J, Bergese SD. Forced-air warming and resistive heating devices. Updated perspectives on safety and surgical site infections. Front Surg. 2018;5:64. https://doi.org/10.3389/fsurg.2018.00064.
Shirozu K, Kai T, Setoguchi H, Ayagaki N, Hoka S. Effects of forced air warming on airflow around the operating table. Anesthesiology. 2018;128:79–84. https://doi.org/10.1097/ALN.0000000000001929.
Boyce JM, Donskey CJ. Understanding ultraviolet light surface decontamination in hospital rooms: a primer. Infect Control Hosp Epidemiol. 2019;40:1030–5. https://doi.org/10.1017/ice.2019.161.
Persson M. Airborne contamination and surgical site infection: could a thirty-year-old idea help solve the problem? Med Hypotheses. 2019;132:109351. https://doi.org/10.1016/j.mehy.2019.109351.
Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725–32. https://doi.org/10.1056/NEJMoa061115.
Vivekanantham S, Ravindran RP, Shanmugarajah K, Maruthappu M, Shalhoub J. Surgical safety checklists in developing countries. Int J Surg. 2014;12:2–6.
Chhabra A, Singh A, Kuka PS, Kaur H, Kuka AS, Chahal H. Role of perioperative surgical safety checklist in reducing morbidity and mortality among patients: an observational study. Niger J Surg. 2019;25:192–7. https://doi.org/10.4103/njs.NJS_45_18.
Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat A-HS, Dellinger EP, et al. A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med. 2009;360:491–9.
•• Allegranzi B, Aiken AM, Zeynep Kubilay N, Nthumba P, Barasa J, Okumu G, et al. A multimodal infection control and patient safety intervention to reduce surgical site infections in Africa: a multicentre, before-after, cohort study. Lancet Infect Dis. 2018;18:507–15. https://doi.org/10.1016/S1473-3099(18)30107-5In this study, Allegranzi and colleagues demonstrated the cost-effectiveness and high quality of a bundle of multimodal infection control practices in low resource settings. Coordinated actions through multidisciplinary teams lead to superior adherence to infection prevention protocols.
Mattingly AS, Starr N, Bitew S, Forrester JA, Negussie T, Merrell SB, et al. Qualitative outcomes of Clean Cut: implementation lessons from reducing surgical infections in Ethiopia. BMC Health Serv Res. 2019;19:579.
Forrester JA, Koritsanszky LA, Amenu D, Haynes AB, Berry WR, Alemu S, et al. Developing process maps as a tool for a surgical infection prevention quality improvement initiative in resource-constrained settings. J Am Coll Surg. 2018;226:1103–1116 e3. https://doi.org/10.1016/j.jamcollsurg.2018.03.020.
Forrester JA, Koritsanszky L, Parsons BD, Hailu M, Amenu D, Alemu S, et al. Development of a surgical infection surveillance program at a tertiary hospital in Ethiopia: lessons learned from two surveillance strategies. Surg Infect (Larchmt). 2018;19:25–32.
Forrester JA, Starr N, Negussie T, Schaps D, Adem M, Alemu S, et al. Clean Cut (adaptive, multimodal surgical infection prevention programme) for low-resource settings: a prospective quality improvement study. Br J Surg 2020; Ahead of print.
Verwey S, Gopalan PD. An investigation of barriers to the use of the World Health Organization Surgical Safety Checklist in theatres. South African Med J. 2018;108:336–41.
Forrester JD, Berndtson AE, Santorelli J, Raschke E, Weiser TG, Coombs AV, et al. Survey of national surgical site infection surveillance programs in low- and middle-income countries. Surg Infect. 2020;21:621–5. https://doi.org/10.1089/sur.2020.053.
Anwer M, Manzoor S, Muneer N, Qureshi S. Compliance and effectiveness of WHO surgical safety check list: a JPMC audit. Pakistan J Med Sci. 2016;32:831.
Kasatpibal N, Senaratana W, Chitreecheur J, Chotirosniramit N, Pakvipas P, Junthasopeepun P. Implementation of the World Health Organization surgical safety checklist at a university hospital in Thailand. Surg Infect (Larchmt). 2012;13:50–6.
Lilaonitkul M, Kwikiriza A, Ttendo S, Kiwanuka J, Munyarungero E, Walker IA, et al. Implementation of the WHO Surgical Safety Checklist and surgical swab and instrument counts at a regional referral hospital in Uganda–a quality improvement project. Anaesthesia. 2015;70:1345–55.
Hellar A, Tibyehabwa L, Ernest E, Varallo J, Betram MM, Fitzgerald L, et al. A Team-based approach to introduce and sustain the use of the WHO Surgical Safety Checklist in Tanzania. World J Surg. 2020;44:689–95.
Organization WH. Preventing surgical site infections: implementation approaches for evidence-based recommendations. 2018.
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Zorrilla-Vaca, A., Marmolejo-Posso, D., Caballero-Lozada, A.F. et al. Sterility and Infection Prevention Standards for Anesthesiologists in LMICs: Preventing Infections and Antimicrobial Resistance. Curr Anesthesiol Rep 11, 128–135 (2021). https://doi.org/10.1007/s40140-021-00441-w
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DOI: https://doi.org/10.1007/s40140-021-00441-w