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Sterility and Infection Prevention Standards for Anesthesiologists in LMICs: Preventing Infections and Antimicrobial Resistance

  • Global Health Anesthesia (M Prin, Section Editor)
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Abstract

Purpose of the Review

Surgical site infections (SSI) affect millions of individuals around the world, leading to a significant burden on perioperative morbidity and healthcare economy. Over the past decade low-income and middle-income countries (LMICs) have made substantial advancements on infection prevention strategies. However, the incidence of SSI is still increasing in many LMICs across all surgical specialties, denoting overlooked areas and ongoing challenges. This article aims to describe the role of anesthesiologists on current standards of infection prevention and sterility as well as ongoing developments in resource-limited settings, with a focus on LMICs.

Recent Findings

Recent estimates indicate a threefold increase in the incidence of SSI across LMICs over the past two decades, approaching two times the estimated SSI incidence of high-income countries. As a result, public health officials have promoted standard practices for infection prevention in the surgical arena by creating multidisciplinary teams and tailoring to the availability of equipment and resources. Anesthesiologists play a pivotal role for the implementation of infection prevention strategies such as antimicrobial prophylaxis, normothermia, intraoperative glucose control, and adequate handling of intravenous anesthetics. Unfortunately, the lack of cohesive practices and leadership structures, along with poor surveillance systems, are still common barriers. One potential method of overcoming these obstacles is investment in sustainable national infection prevention programs.

Summary

Infection prevention standards should be tailored to local workflow and institutional resources. The successful implementation of programs in LMICs depends on sustainable national infection prevention programs which includes a well-trained team and an institutional climate of safety.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Berrios-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152:784–91. https://doi.org/10.1001/jamasurg.2017.0904.

    Article  PubMed  Google Scholar 

  2. Rickard J, Beilman G, Forrester J, Sawyer R, Stephen A, Weiser TG, et al. Surgical infections in low- and middle-income countries: a global assessment of the burden and management needs. Surg Infect. 2020;21:478–94. https://doi.org/10.1089/sur.2019.142.

    Article  Google Scholar 

  3. Biccard BM, Madiba TE, Kluyts H-L, Munlemvo DM, Madzimbamuto FD, Basenero A, et al. Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet. 2018;391:1589–98.

    Article  Google Scholar 

  4. Pittet D, Allegranzi B, Storr J, Bagheri Nejad S, Dziekan G, Leotsakos A, et al. Infection control as a major World Health Organization priority for developing countries. J Hosp Infect. 2008;68:285–92. https://doi.org/10.1016/j.jhin.2007.12.013.

    Article  CAS  PubMed  Google Scholar 

  5. •• GlobalSurg C. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis. 2018;18:516–25. https://doi.org/10.1016/S1473-3099(18)30101-4This is the largest cohort study evaluating the epidemiology of surgical site infection in LMICs, including trends and risk factors in geographic areas with the highest incidence of infections. The authors highlight the significant burden of surgical site infection and its relationship with healthcare disparities.

    Article  Google Scholar 

  6. Jepsen OB, Jensen LP, Zimakoff J, Friis H, Bissoonauthsing CN, Kasenally AT, et al. Prevalence of infections and use of antibiotics among hospitalized patients in Mauritius. A nationwide survey for the planning of a national infection control programme. J Hosp Infect. 1993;25:271–8.

    Article  CAS  Google Scholar 

  7. Surgery NI, for HRGRHU on G, Nepogodiev D, Adisa A, Abantanga FA, Ademuyiwa A, et al. Delphi prioritization and development of global surgery guidelines for the prevention of surgical-site infection. Br J Surg 2020;107(8):970–77.

  8. Yezli S, Barbut F, Otter JA. Surface contamination in operating rooms: a risk for transmission of pathogens? Surg Infect (Larchmt). 2014;15:694–9.

    Article  Google Scholar 

  9. Leaper DJ, Edmiston CE. World Health Organization: global guidelines for the prevention of surgical site infection. J Hosp Infect. 2017;95:135–6. https://doi.org/10.1016/j.jhin.2016.12.016.

    Article  CAS  PubMed  Google Scholar 

  10. Rutala WA, Weber DJ. Guideline for disinfection and sterilization in healthcare facilities, 2008. 2008.

    Google Scholar 

  11. O’Hara NN, Patel KR, Caldwell A, Shone S, Bryce EA. Sterile reprocessing of surgical instruments in low-and middle-income countries: a multicenter pilot study. Am J Infect Control. 2015;43:1197–200.

    Article  Google Scholar 

  12. Link T. Guideline implementation: manual chemical high-level disinfection: 1.5 www. aornjournal. org/content/cme. AORN J. 2018;108:399–410.

    Article  Google Scholar 

  13. Zorrilla-Vaca A, Escandón-Vargas K, Brand-Giraldo V, Leon T, Herrera M, Payan A. Bacterial contamination of propofol vials used in operating rooms of a third-level hospital. Am J Infect Control. 2015;In-press:e1–3.

    Google Scholar 

  14. Zorrilla-Vaca A, Escandón-Vargas K. The importance of infection control and prevention in anesthesiology. Rev Colomb Anestesiol. 2017;45:69.

    Article  Google Scholar 

  15. • Zorrilla-Vaca A, Arevalo J, Escandón-Vargas K, Soltanifar D, Mirski M. Infectious diseases risk and propofol anesthesia, 1989–2014. Emerg Infect Dis 2016; 22(6)981–92. The authors compiled all the anesthesia-associated outbreaks related to contaminated propofol administration. The most common causes of the outbreaks are the reuse of syringes in low resource settings, use of single-dose vials for multiple patients and inadequate aseptic technique.

  16. Section IV Implementation Manual for the World Health Organization Surgical Safety Checklist. In: WHO guidelines for safe surgery 2009: safe surgery saves lives. Geneva; 2009. https://www.ncbi.nlm.nih.gov/pubmed/23762968.

  17. Boyce JM. Current issues in hand hygiene. Am J Infect Control. 2019;47:A46–52.

    Article  Google Scholar 

  18. Omuemu VO, Ogboghodo EO, Opene RA, Oriarewo P, Onibere O. Hand hygiene practices among doctors in a tertiary health facility in southern Nigeria. J Med Trop. 2013;15:96.

    Article  Google Scholar 

  19. Gon G, de Bruin M, de Barra M, Ali SM, Campbell OM, Graham WJ, et al. Hands washing, glove use, and avoiding recontamination before aseptic procedures at birth: a multicenter time-and-motion study conducted in Zanzibar. Am J Infect Control. 2019;47:149–56.

    Article  Google Scholar 

  20. Ataiyero Y, Dyson J, Graham M. Barriers to hand hygiene practices among health care workers in sub-Saharan African countries: a narrative review. Am J Infect Control. 2019;47:565–73.

    Article  Google Scholar 

  21. Lindsjo C, Sharma M, Mahadik VK, Sharma S, Stalsby Lundborg C, Pathak A. Surgical site infections, occurrence, and risk factors, before and after an alcohol-based handrub intervention in a general surgical department in a rural hospital in Ujjain, India. Am J Infect Control. 2015;43:1184–9. https://doi.org/10.1016/j.ajic.2015.06.010.

    Article  PubMed  Google Scholar 

  22. Kampf G, Kramer A. Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs. Clin Microbiol Rev. 2004;17:863–93.

    Article  Google Scholar 

  23. Parienti JJ, Thibon P, Heller R, Le Roux Y, von Theobald P, Bensadoun H, et al. Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study. Jama. 2002;288:722–7.

    Article  Google Scholar 

  24. Nthumba PM, Stepita-Poenaru E, Poenaru D, Bird P, Allegranzi B, Pittet D, et al. Cluster-randomized, crossover trial of the efficacy of plain soap and water versus alcohol-based rub for surgical hand preparation in a rural hospital in Kenya. Br J Surg. 2010;97:1621–8. https://doi.org/10.1002/bjs.7213.

    Article  CAS  PubMed  Google Scholar 

  25. Reilly JS, Price L, Lang S, Robertson C, Cheater F, Skinner K, et al. A pragmatic randomized controlled trial of 6-step vs 3-step hand hygiene technique in acute hospital care in the United Kingdom. Infect Control Hosp Epidemiol. 2016;37:661–6.

    Article  Google Scholar 

  26. Tschudin-Sutter S, Sepulcri D, Dangel M, Ulrich A, Frei R, Widmer AF. Simplifying the World Health Organization protocol: 3 steps versus 6 steps for performance of hand hygiene in a cluster-randomized trial. Clin Infect Dis. 2019;69:614–20.

    Article  Google Scholar 

  27. Munoz-Price LS, Birnbach DJ. Hand hygiene and anesthesiology. Int Anesthesiol Clin. 2013;51:79–92. https://doi.org/10.1097/AIA.0b013e31826f2db6.

    Article  PubMed  Google Scholar 

  28. • Munoz-Price LS, Bowdle A, Johnston BL, Bearman G, Camins BC, Dellinger EP. et al., Infection prevention in the operating room anesthesia work area. Infect Control Hosp Epidemiol. 2018:1–17. https://doi.org/10.1017/ice.2018.303The authors updated the current guidelines for infection prevention in the anesthesia work area. In summary, anesthesiologists should comply with the 5-moments of hand hygiene in any procedure that involve contact with surfaces, avoid reusing of single-dose vials, and adopt adequate aseptic technique for any invasive procedure.

  29. Sherman JD, Hopf HW. Balancing infection control and environmental protection as a matter of patient safety: the case of laryngoscope handles. Anesth Analg. 2018;127:576–9. https://doi.org/10.1213/ANE.0000000000002759.

    Article  PubMed  Google Scholar 

  30. Lowman W, Venter L, Scribante J. Bacterial contamination of re-usable laryngoscope blades during the course of daily anaesthetic practice. S Afr Med J. 2013;103:386–9. https://doi.org/10.7196/samj.6385.

    Article  PubMed  Google Scholar 

  31. Mitchell KF, Barker AK, Abad CL, Safdar N. Infection control at an urban hospital in Manila, Philippines: a systems engineering assessment of barriers and facilitators. Antimicrob Resist Infect Control. 2017;6:90.

    Article  Google Scholar 

  32. Sherman JD, Raibley LA t, Eckelman MJ. Life cycle assessment and costing methods for device procurement: comparing reusable and single-use disposable laryngoscopes. Anesth Analg. 2018;127:434–43. https://doi.org/10.1213/ANE.0000000000002683.

    Article  PubMed  Google Scholar 

  33. Shohat N, Goswami K, Tarabichi M, Sterbis E, Tan TL, Parvizi J. All patients should be screened for diabetes before total joint arthroplasty. J Arthroplasty. 2018;33:2057–61.

    Article  Google Scholar 

  34. Mueck KM, Kao LS. Patients at high-risk for surgical site infection. Surg Infect. 2017;18:440–6. https://doi.org/10.1089/sur.2017.058.

    Article  Google Scholar 

  35. Van der Spuy K, Crowther M, Nejthardt M, Roodt F, Davids J, Roos J, et al. A multicentre, cross-sectional study investigating the prevalence of hypertensive disease in patients presenting for elective surgery in the Western Cape Province, Souht Africa. S Afr Med J. 2018;108:590–5. https://doi.org/10.7196/SAMJ.2018.v108i7.13022.

    Article  PubMed  Google Scholar 

  36. Biesman-Simons T, Conradie WS, Nejthardt M, Roodt F, Davids J, Pretorius T, et al. A multicentre prospective observational study of the prevalence and glycaemic control of diabetes mellitus in adult non-cardiac elective surgical patients in hospitals in Western Cape Province. South Africa. S Afr Med J. 2019;109:801–6. https://doi.org/10.7196/SAMJ.2019.v109i10.013898.

    Article  CAS  PubMed  Google Scholar 

  37. Muchuweti D, Jönsson KUG. Abdominal surgical site infections: a prospective study of determinant factors in Harare, Zimbabwe. Int Wound J. 2015;12:517–22.

    Article  Google Scholar 

  38. Bordes J, Cungi P, Savoie P, Bonnet S, Kaiser E. Usefulness of routine preoperative testing in a developing country: a prospective study. Pan Afr Med J. 2015;21:94.

    Article  Google Scholar 

  39. Decker BK, Nagrebetsky A, Lipsett PA, Wiener-Kronish JP, O’Grady NP. Controversies in perioperative antimicrobial prophylaxis. Anesthesiology. 2020;132:586–97. https://doi.org/10.1097/ALN.0000000000003075.

    Article  PubMed  Google Scholar 

  40. Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surg Infect. 2013;14:73–156. https://doi.org/10.1089/sur.2013.9999.

    Article  Google Scholar 

  41. Van Dijck C, Vlieghe E, Cox JA. Antibiotic stewardship interventions in hospitals in low-and middle-income countries: a systematic review. Bull World Health Organ. 2018;96:266.

    Article  Google Scholar 

  42. Al-Momany NH, Al-Bakri AG, Makahleh ZM, Wazaify MM. Adherence to international antimicrobial prophylaxis guidelines in cardiac surgery: a Jordanian study demonstrates need for quality improvement. J Manag Care Pharm. 2009;15:262–71. https://doi.org/10.18553/jmcp.2009.15.3.262.

    Article  PubMed  Google Scholar 

  43. Abubakar U, Syed Sulaiman SA, Adesiyun AG. Utilization of surgical antibiotic prophylaxis for obstetrics and gynaecology surgeries in Northern Nigeria. Int J Clin Pharm. 2018;40:1037–43. https://doi.org/10.1007/s11096-018-0702-0.

    Article  CAS  PubMed  Google Scholar 

  44. Saied T, Hafez SF, Kandeel A, El-Kholy A, Ismail G, Aboushady M, et al. Antimicrobial stewardship to optimize the use of antimicrobials for surgical prophylaxis in Egypt: a multicenter pilot intervention study. Am J Infect Control. 2015;43:e67–71.

    Article  Google Scholar 

  45. Davey P, Brown E, Charani E, Fenelon L, Gould IM, Holmes A, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2017;9(2):CD003543.

  46. Satti MZ, Hamza M, Sajid Z, Asif O, Ahmed H, Zaidi SMJ, et al. Compliance rate of surgical antimicrobial prophylaxis and its association with knowledge of guidelines among surgical residents in a tertiary care public hospital of a developing country. Cureus. 2019;11:e4776.

    PubMed  PubMed Central  Google Scholar 

  47. Olaoye O, Tuck C, Khor WP, McMenamin R, Hudson L, Northall M, et al. Improving access to antimicrobial prescribing guidelines in 4 African countries: development and pilot implementation of an app and cross-sectional assessment of attitudes and behaviour survey of healthcare workers and patients. Antibiotics. 2020;9:555.

    Article  Google Scholar 

  48. Charani E, Smith I, Skodvin B, Perozziello A, Lucet JC, Lescure FX, et al. Investigating the cultural and contextual determinants of antimicrobial stewardship programmes across low-, middle- and high-income countries-a qualitative study. PLoS One. 2019;14:e0209847. https://doi.org/10.1371/journal.pone.0209847.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Thomas S, Palmer R, Phillipo E, Chipungu G. Reducing bacterial contamination in an orthopedic theatre ventilated by natural ventilation, in a developing country. J Infect Dev Ctries. 2016;10:518–22. https://doi.org/10.3855/jidc.7436.

    Article  PubMed  Google Scholar 

  50. Ackermann W, Fan Q, Parekh AJ, Stoicea N, Ryan J, Bergese SD. Forced-air warming and resistive heating devices. Updated perspectives on safety and surgical site infections. Front Surg. 2018;5:64. https://doi.org/10.3389/fsurg.2018.00064.

  51. Shirozu K, Kai T, Setoguchi H, Ayagaki N, Hoka S. Effects of forced air warming on airflow around the operating table. Anesthesiology. 2018;128:79–84. https://doi.org/10.1097/ALN.0000000000001929.

    Article  PubMed  Google Scholar 

  52. Boyce JM, Donskey CJ. Understanding ultraviolet light surface decontamination in hospital rooms: a primer. Infect Control Hosp Epidemiol. 2019;40:1030–5. https://doi.org/10.1017/ice.2019.161.

    Article  PubMed  Google Scholar 

  53. Persson M. Airborne contamination and surgical site infection: could a thirty-year-old idea help solve the problem? Med Hypotheses. 2019;132:109351. https://doi.org/10.1016/j.mehy.2019.109351.

    Article  PubMed  Google Scholar 

  54. Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725–32. https://doi.org/10.1056/NEJMoa061115.

    Article  CAS  PubMed  Google Scholar 

  55. Vivekanantham S, Ravindran RP, Shanmugarajah K, Maruthappu M, Shalhoub J. Surgical safety checklists in developing countries. Int J Surg. 2014;12:2–6.

    Article  Google Scholar 

  56. Chhabra A, Singh A, Kuka PS, Kaur H, Kuka AS, Chahal H. Role of perioperative surgical safety checklist in reducing morbidity and mortality among patients: an observational study. Niger J Surg. 2019;25:192–7. https://doi.org/10.4103/njs.NJS_45_18.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat A-HS, Dellinger EP, et al. A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med. 2009;360:491–9.

    Article  CAS  Google Scholar 

  58. •• Allegranzi B, Aiken AM, Zeynep Kubilay N, Nthumba P, Barasa J, Okumu G, et al. A multimodal infection control and patient safety intervention to reduce surgical site infections in Africa: a multicentre, before-after, cohort study. Lancet Infect Dis. 2018;18:507–15. https://doi.org/10.1016/S1473-3099(18)30107-5In this study, Allegranzi and colleagues demonstrated the cost-effectiveness and high quality of a bundle of multimodal infection control practices in low resource settings. Coordinated actions through multidisciplinary teams lead to superior adherence to infection prevention protocols.

    Article  PubMed  Google Scholar 

  59. Mattingly AS, Starr N, Bitew S, Forrester JA, Negussie T, Merrell SB, et al. Qualitative outcomes of Clean Cut: implementation lessons from reducing surgical infections in Ethiopia. BMC Health Serv Res. 2019;19:579.

    Article  Google Scholar 

  60. Forrester JA, Koritsanszky LA, Amenu D, Haynes AB, Berry WR, Alemu S, et al. Developing process maps as a tool for a surgical infection prevention quality improvement initiative in resource-constrained settings. J Am Coll Surg. 2018;226:1103–1116 e3. https://doi.org/10.1016/j.jamcollsurg.2018.03.020.

    Article  PubMed  Google Scholar 

  61. Forrester JA, Koritsanszky L, Parsons BD, Hailu M, Amenu D, Alemu S, et al. Development of a surgical infection surveillance program at a tertiary hospital in Ethiopia: lessons learned from two surveillance strategies. Surg Infect (Larchmt). 2018;19:25–32.

    Article  Google Scholar 

  62. Forrester JA, Starr N, Negussie T, Schaps D, Adem M, Alemu S, et al. Clean Cut (adaptive, multimodal surgical infection prevention programme) for low-resource settings: a prospective quality improvement study. Br J Surg 2020; Ahead of print.

  63. Verwey S, Gopalan PD. An investigation of barriers to the use of the World Health Organization Surgical Safety Checklist in theatres. South African Med J. 2018;108:336–41.

    Article  CAS  Google Scholar 

  64. Forrester JD, Berndtson AE, Santorelli J, Raschke E, Weiser TG, Coombs AV, et al. Survey of national surgical site infection surveillance programs in low- and middle-income countries. Surg Infect. 2020;21:621–5. https://doi.org/10.1089/sur.2020.053.

    Article  Google Scholar 

  65. Anwer M, Manzoor S, Muneer N, Qureshi S. Compliance and effectiveness of WHO surgical safety check list: a JPMC audit. Pakistan J Med Sci. 2016;32:831.

    Google Scholar 

  66. Kasatpibal N, Senaratana W, Chitreecheur J, Chotirosniramit N, Pakvipas P, Junthasopeepun P. Implementation of the World Health Organization surgical safety checklist at a university hospital in Thailand. Surg Infect (Larchmt). 2012;13:50–6.

    Article  Google Scholar 

  67. Lilaonitkul M, Kwikiriza A, Ttendo S, Kiwanuka J, Munyarungero E, Walker IA, et al. Implementation of the WHO Surgical Safety Checklist and surgical swab and instrument counts at a regional referral hospital in Uganda–a quality improvement project. Anaesthesia. 2015;70:1345–55.

    Article  CAS  Google Scholar 

  68. Hellar A, Tibyehabwa L, Ernest E, Varallo J, Betram MM, Fitzgerald L, et al. A Team-based approach to introduce and sustain the use of the WHO Surgical Safety Checklist in Tanzania. World J Surg. 2020;44:689–95.

    Article  Google Scholar 

  69. Organization WH. Preventing surgical site infections: implementation approaches for evidence-based recommendations. 2018.

    Google Scholar 

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Zorrilla-Vaca, A., Marmolejo-Posso, D., Caballero-Lozada, A.F. et al. Sterility and Infection Prevention Standards for Anesthesiologists in LMICs: Preventing Infections and Antimicrobial Resistance. Curr Anesthesiol Rep 11, 128–135 (2021). https://doi.org/10.1007/s40140-021-00441-w

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