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Current Translational Challenges for Tissue Engineering: 3D Culture, Nanotechnology, and Decellularized Matrices

  • Stem Cells and Regeneration (Udayan Apte, Section Editor)
  • Published:
Current Pathobiology Reports

Abstract

Tissue engineering and regenerative medicine aim to alleviate the gaps in clinical treatment options for addressing critical defect disorders otherwise left untreated. Ongoing attempts to translate research findings to clinical applications have progressed slower than expected but continue to evolve within the three key areas of cells, signals, and scaffolds. Within these areas, approaches have developed that are evolving our clinical options for addressing disorders as well as improving high-throughout screening techniques to optimize our therapeutic options in tomorrow’s clinic. Such approaches include, but are not limited to, selecting the proper cell sources, engineering artificial and natural biomaterial substrates, bioprinting, microfluidic platforms, and whole organ matrices. Here we review recent advancements in these areas as to better understand where the field is headed.

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References

Recently published papers of particular interest have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Department of Pediatrics, University of Florida, PO Box 100296, Gainesville, FL, 32610-0296, USA

    David C. Sullivan, Adam W. Frock & Bryon E. Petersen

  2. 101 Science Dr, 136 Hudson Hall, PO Box 90281, Durham, NC, 27708, USA

    Jonathan P. Repper

  3. 1275 Center Drive, Biomedical Sciences Building J391, Gainesville, FL, 32611, USA

    Peter S. McFetridge

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  1. David C. Sullivan
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  2. Jonathan P. Repper
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  3. Adam W. Frock
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  5. Bryon E. Petersen
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Correspondence to Bryon E. Petersen.

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This article is part of the Topical Collection on Stem Cells and Regeneration.

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Sullivan, D.C., Repper, J.P., Frock, A.W. et al. Current Translational Challenges for Tissue Engineering: 3D Culture, Nanotechnology, and Decellularized Matrices. Curr Pathobiol Rep 3, 99–106 (2015). https://doi.org/10.1007/s40139-015-0066-2

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