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Elucidating Metabolic and Epigenetic Mechanisms that Regulate Liver Regeneration

  • Stem Cells and Regeneration (Udayan Apte, Section Editor)
  • Published:
Current Pathobiology Reports

Abstract

The regenerative capability of the liver is essential for recovery from all hepatic injuries. Although long studied, the signals that regulate such regeneration require further elucidation if knowledge about regenerative mechanisms is to be translated into improved clinical therapy. Alterations in metabolism have been the focus of recent experimental investigations as a possible source of essential signals that control liver regeneration. Although the specific mechanisms linking metabolism and regeneration remain unknown, specific growth factors, secondary messengers, and transcription factors have been suggested by published analyses. Epigenetic mechanisms are also emerging as potential intermediaries between hepatic insufficiency-induced changes in metabolism and regenerative hepatocellular proliferation. This article reviews the recent literature relevant to these considerations, with particular emphasis on contemporary data that link metabolic and epigenetic signals to the regulation of liver regulation. The relevance of metabolic–epigenetic regulation of experimental hepatic regeneration with respect to human liver diseases is also briefly considered.

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  1. Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, Box 8208, St. Louis, MO, 63110, USA

    Jiansheng Huang & David A. Rudnick

  2. Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    David A. Rudnick

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  1. Jiansheng Huang
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Correspondence to David A. Rudnick.

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This article is part of the Topical Collection on Stem Cells and Regeneration.

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Huang, J., Rudnick, D.A. Elucidating Metabolic and Epigenetic Mechanisms that Regulate Liver Regeneration. Curr Pathobiol Rep 3, 89–98 (2015). https://doi.org/10.1007/s40139-015-0065-3

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