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Obstructive Sleep Apnea in the Very Young

  • Pediatric Otolaryngology (I Bruce, Section Editor)
  • Published:
Current Otorhinolaryngology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The aim of this report was to review the recent literature related to the assessment and management of obstructive sleep apnea (OSA) in children under the age of 2 years.

Recent Findings

Adenotonsillectomy (AT) indications are changing, with a greater proportion of younger children undergoing AT for OSA. Medical therapies may be an alternative to AT in mild-moderate OSA cases; however, further research is needed. Coblation® intracapsular tonsillectomy may confer benefits in reduced post-operative pain and hemorrhage. Recent concerns regarding the safety of general anesthesia in young children are an important area for further investigation.

Summary

There is a paucity of literature related to OSA in children younger than 2 years. Recent large-scale trials have actively excluded children from this age group and there are no planned studies of this specific population. These children represent a distinct population with differing etiologies, presentations, investigations, and management consideration.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Section on Pediatric Pulmonology SoOSASAAoP. Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome.[see comment]. Pediatrics. 2002;109:(4)704–712. https://doi.org/10.1542/peds.109.4.704.

  2. Muzumdar H, Arens R. Physiological effects of obstructive sleep apnea syndrome in childhood. Respir Physiol Neurobiol. 2013;188(3):370–82. https://doi.org/10.1016/j.resp.2013.05.006.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Walter LM, Nixon GM, Davey MJ, O’Driscoll DM, Trinder J, Horne RSC. Sleep disturbance in pre-school children with obstructive sleep apnoea syndrome. Sleep Med. 2011;12(9):880–6. https://doi.org/10.1016/j.sleep.2011.07.007.

    Article  PubMed  Google Scholar 

  4. Marcus CL. Pathophysiology of childhood obstructive sleep apnea: current concepts. Respir Physiol. 2000;119(2-3):143–54. https://doi.org/10.1016/S0034-5687(99)00109-7.

    Article  CAS  PubMed  Google Scholar 

  5. Shine NP, Coates HL, Lannigan FJ. Obstructive sleep apnea, morbid obesity, and adenotonsillar surgery: a review of the literature. Int J Pediatr Otorhinolaryngol. 2005;69(11):1475–82. https://doi.org/10.1016/j.ijporl.2005.08.008.

    Article  PubMed  Google Scholar 

  6. Childhood RWPoSPaRCDi. Standards for services for children with disorders of sleep physiology. 2009.

  7. Don DM, Geller KA, Koempel JA, Ward SD. Age specific differences in pediatric obstructive sleep apnea. Int J Pediatr Otorhinolaryngol. 2009;73(7):1025–8. https://doi.org/10.1016/j.ijporl.2009.04.003.

    Article  PubMed  Google Scholar 

  8. Dickison AE. The normal and abnormal pediatric upper airway. Recognition and management of obstruction. Clin Chest Med. 1987;8(4):583–96.

    CAS  PubMed  Google Scholar 

  9. Swift PG, Emery JL. Clinical observations on response to nasal occlusion in infancy. Arch Dis Child. 1973;48(12):947–51. https://doi.org/10.1136/adc.48.12.947.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Brietzke SE, Katz ES, Roberson DW. Can history and physical examination reliably diagnose pediatric obstructive sleep apnea/hypopnea syndrome? A systematic review of the literature. Otolaryngol Head Neck Surg. 2004;131(6):827–32. https://doi.org/10.1016/j.otohns.2004.07.002.

    Article  PubMed  Google Scholar 

  11. Moore M, Bonuck K. Comorbid symptoms of sleep-disordered breathing and behavioral sleep problems from 18-57 months of age: a population-based study. Behav Sleep Med. 2013;11(3):222–30. https://doi.org/10.1080/15402002.2012.666219.

    Article  PubMed  Google Scholar 

  12. Nolan J, Brietzke SE. Systematic review of pediatric tonsil size and polysomnogram-measured obstructive sleep apnea severity. Otolaryngol Head Neck Surg. 2011;144(6):844–50. https://doi.org/10.1177/0194599811400683.

    Article  PubMed  Google Scholar 

  13. Tang A, Benke JR, Cohen AP, Ishman SL. Influence of tonsillar size on OSA improvement in children undergoing adenotonsillectomy. Otolaryngol Head Neck Surg. 2015;153(2):281–5. https://doi.org/10.1177/0194599815583459.

    Article  PubMed  Google Scholar 

  14. Qubty WF, Mrelashvili A, Kotagal S, Lloyd RM. Comorbidities in infants with obstructive sleep apnea. J Clin Sleep Med. 2014;10(11):1213–6. https://doi.org/10.5664/jcsm.4204.

    PubMed  PubMed Central  Google Scholar 

  15. Tan HL, Kheirandish-Gozal L, Abel F, Gozal D. Craniofacial syndromes and sleep-related breathing disorders. Sleep Med Rev. 2016;27:74–88. https://doi.org/10.1016/j.smrv.2015.05.010.

    Article  PubMed  Google Scholar 

  16. Garcia J, Wical B, Wical W, Schaffer L, Wical T, Wendorf H, et al. Obstructive sleep apnea in children with cerebral palsy and epilepsy. Dev Med Child Neurol. 2016;58(10):1057–62. https://doi.org/10.1111/dmcn.13091.

    Article  PubMed  Google Scholar 

  17. Dinwiddie R. Congenital upper airway obstruction. Paediatr Respir Rev. 2004;5(1):17–24. https://doi.org/10.1016/j.prrv.2003.10.001.

    Article  PubMed  Google Scholar 

  18. Rastatter JC, Schroeder JW Jr, French A, Holinger L. Synchronous airway lesions in children younger than age 3 years undergoing adenotonsillectomy. Otolaryngol Head Neck Surg. 2011;145(2):309–13. https://doi.org/10.1177/0194599811403071.

    Article  PubMed  Google Scholar 

  19. Daar G, Sari K, Gencer ZK, et al. The relation between childhood obesity and adenotonsillar hypertrophy. Eur Arch Otorhinolaryngol. 2016;273(2):505–9. https://doi.org/10.1007/s00405-015-3554-4.

    Article  PubMed  Google Scholar 

  20. Lam YY, Chan EY, Ng DK, et al. The correlation among obesity, apnea-hypopnea index, and tonsil size in children. Chest. 2006;130(6):1751–6. https://doi.org/10.1378/chest.130.6.1751.

    Article  PubMed  Google Scholar 

  21. Kang KT, Chou CH, Weng WC, Lee PL, Hsu WC. Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea. PLoS One. 2013;8(10):e78666. https://doi.org/10.1371/journal.pone.0078666.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Xu Z, Jiaqing A, Yuchuan L, Shen K. A case-control study of obstructive sleep apnea-hypopnea syndrome in obese and nonobese chinese children. Chest. 2008;133(3):684–9. https://doi.org/10.1378/chest.07-1611.

    Article  PubMed  Google Scholar 

  23. Coles N, Birken C, Hamilton J. Emerging treatments for severe obesity in children and adolescents. BMJ. 2016;354:i4116.

    Article  PubMed  Google Scholar 

  24. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002;288(14):1723–7. https://doi.org/10.1001/jama.288.14.1723.

    Article  PubMed  Google Scholar 

  25. Gittner LS, Ludington-Hoe SM, Haller HS. Infant obesity and severe obesity growth patterns in the first two years of life. Matern Child Health J. 2014;18(3):613–24. https://doi.org/10.1007/s10995-013-1285-y.

    Article  PubMed  Google Scholar 

  26. • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014;311(8):806–14. Good overview of the impact of childhood obesity. https://doi.org/10.1001/jama.2014.732.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Costa DJ, Mitchell R. Adenotonsillectomy for obstructive sleep apnea in obese children: a meta-analysis. Otolaryngol Head Neck Surg. 2009;140(4):455–60. https://doi.org/10.1016/j.otohns.2008.12.038.

    Article  PubMed  Google Scholar 

  28. Imanguli M, Ulualp SO. Risk factors for residual obstructive sleep apnea after adenotonsillectomy in children. Laryngoscope. 2016;126(11):2624–9. https://doi.org/10.1002/lary.25979.

    Article  PubMed  Google Scholar 

  29. Brouillette RT, Morielli A, Leimanis A, Waters KA, Luciano R, Ducharme FM. Nocturnal pulse oximetry as an abbreviated testing modality for pediatric obstructive sleep apnea. Pediatrics. 2000;105(2):405–12. https://doi.org/10.1542/peds.105.2.405.

    Article  CAS  PubMed  Google Scholar 

  30. Walter LM, Nixon GM, Davey MJ, Anderson V, Trinder J, Walker A, et al. Differential effects of sleep disordered breathing on polysomnographic characteristics in preschool and school aged children. Sleep Med. 2012;13(7):810–5. https://doi.org/10.1016/j.sleep.2012.03.014.

    Article  PubMed  Google Scholar 

  31. DeHaan KL, Seton C, Fitzgerald DA, Waters KA, MacLean JE. Polysomnography for the diagnosis of sleep disordered breathing in children under 2 years of age. Pediatr Pulmonol. 2015;50(12):1346–53. https://doi.org/10.1002/ppul.23169.

    Article  PubMed  Google Scholar 

  32. Barnes ME, Gozal D, Molfese DL. Attention in children with obstructive sleep apnoea: an event-related potentials study. Sleep Med. 2012;13(4):368–77. https://doi.org/10.1016/j.sleep.2011.06.007.

    Article  PubMed  Google Scholar 

  33. Persak SC, Sin S, McDonough JM, Arens R, Wootton DM. Noninvasive estimation of pharyngeal airway resistance and compliance in children based on volume-gated dynamic MRI and computational fluid dynamics. J Appl Physiol. 2011;111(6):1819–27. https://doi.org/10.1152/japplphysiol.01230.2010.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Bani MMM, Az-Zaqah R, Aldofash AK, et al. Contactless method for detection of infant sleep apnoea. J Med Eng Technol. 2010;34(5-6):324–8. https://doi.org/10.3109/03091902.2010.481034.

    Article  Google Scholar 

  35. Revenaugh PC, Chmielewski LJ, Edwards T, Krishna J, Krakovitz P, Anne S. Utility of preoperative cardiac evaluation in pediatric patients undergoing surgery for obstructive sleep apnea. Arch Otolaryngol Head Neck Surg. 2011;137(12):1269–75. https://doi.org/10.1001/archoto.2011.208.

    Article  PubMed  Google Scholar 

  36. Section on Pediatric Pulmonology SoOSASAAoP. Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2002;109:704–12.

    Article  Google Scholar 

  37. Goldberg S, Shatz A, Picard E, Wexler I, Schwartz S, Swed E, et al. Endoscopic findings in children with obstructive sleep apnea: effects of age and hypotonia. Pediatr Pulmonol. 2005;40(3):205–10. https://doi.org/10.1002/ppul.20230.

    Article  PubMed  Google Scholar 

  38. Lin AC, Koltai PJ. Sleep endoscopy in the evaluation of pediatric obstructive sleep apnea. Int J Pediatr. 2012;2012:576719.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Durr ML, Meyer AK, Kezirian EJ, Rosbe KW. Drug-induced sleep endoscopy in persistent pediatric sleep-disordered breathing after adenotonsillectomy. Arch Otolaryngol Head Neck Surg. 2012;138(7):638–43. https://doi.org/10.1001/archoto.2012.1067.

    Article  PubMed  Google Scholar 

  40. Marcus CL, Radcliffe J, Konstantinopoulou S, Beck SE, Cornaglia MA, Traylor J, et al. Effects of positive airway pressure therapy on neurobehavioral outcomes in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2012;185(9):998–1003. https://doi.org/10.1164/rccm.201112-2167OC.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Simon SL, Duncan CL, Janicke DM, Wagner MH. Barriers to treatment of paediatric obstructive sleep apnoea: development of the adherence barriers to continuous positive airway pressure (CPAP) questionnaire. Sleep Med. 2012;13(2):172–7. https://doi.org/10.1016/j.sleep.2011.10.026.

    Article  PubMed  Google Scholar 

  42. Marcus CL, Beck SE, Traylor J, et al. Randomized, double-blind clinical trial of two different modes of positive airway pressure therapy on adherence and efficacy in children. J Clin Sleep Med. 2012;8(1):37–42. https://doi.org/10.5664/jcsm.1656.

    PubMed  PubMed Central  Google Scholar 

  43. Downey R 3rd, Perkin RM, MacQuarrie J. Nasal continuous positive airway pressure use in children with obstructive sleep apnea younger than 2 years of age. Chest. 2000;117(6):1608–12. https://doi.org/10.1378/chest.117.6.1608.

    Article  PubMed  Google Scholar 

  44. Miller MJ, Carlo WA, Martin RJ. Continuous positive airway pressure selectively reduces obstructive apnea in preterm infants. J Pediatr. 1985;106(1):91–4. https://doi.org/10.1016/S0022-3476(85)80475-3.

    Article  CAS  PubMed  Google Scholar 

  45. McNamara F, Sullivan CE. Effects of nasal CPAP therapy on respiratory and spontaneous arousals in infants with OSA. J Appl Physiol (1985). 1999;87(3):889–96. https://doi.org/10.1152/jappl.1999.87.3.889.

    Article  CAS  Google Scholar 

  46. Verhulst SL, Franckx H, Van Gaal L, de Backer W, Desager K. The effect of weight loss on sleep-disordered breathing in obese teenagers. Obesity (Silver Spring). 2009;17(6):1178–83. https://doi.org/10.1038/oby.2008.673.

    Google Scholar 

  47. Van K, Franckx H, Debode P, et al. Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid. Obesity. 2012;20:172–7.

    Article  Google Scholar 

  48. Kuhle S, Urschitz MS. Anti-inflammatory medications for obstructive sleep apnea in children. Cochrane Database Syst Rev. 2011; https://doi.org/10.1002/14651858.CD007074.pub2.

  49. Kheirandish-Gozal L, Bandla HP, Gozal D. Montelukast for children with obstructive sleep apnea: results of a double-blind, randomized, placebo-controlled trial. Ann Am Thorac Soc. 2016;13(10):1736–41. https://doi.org/10.1513/AnnalsATS.201606-432OC.

    PubMed  Google Scholar 

  50. Goldbart AD, Greenberg-Dotan S, Tal A. Montelukast for children with obstructive sleep apnea: a double-blind, placebo-controlled study. Pediatrics. 2012;130(3):e575–80. https://doi.org/10.1542/peds.2012-0310.

    Article  PubMed  Google Scholar 

  51. Kheirandish-Gozal L, Bhattacharjee R, Bandla HPR, Gozal D. Antiinflammatory therapy outcomes for mild OSA in children. Chest. 2014;146(1):88–95. https://doi.org/10.1378/chest.13-2288.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Czinn SJ, Blanchard S. Gastroesophageal reflux disease in neonates and infants: when and how to treat. Paediatr Drugs. 2013;15(1):19–27. https://doi.org/10.1007/s40272-012-0004-2.

    Article  PubMed  Google Scholar 

  53. Wasilewska J, Semeniuk J, Cudowska B, Klukowski M, Dębkowska K, Kaczmarski M. Respiratory response to proton pump inhibitor treatment in children with obstructive sleep apnea syndrome and gastroesophageal reflux disease. Sleep Med. 2012;13(7):824–30. https://doi.org/10.1016/j.sleep.2012.04.016.

    Article  PubMed  Google Scholar 

  54. Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012;130(3):e714–55. https://doi.org/10.1542/peds.2012-1672.

    Article  PubMed  Google Scholar 

  55. Cullen KA, Hall MJ, Golosinskiy A. Ambulatory surgery in the United States, 2006. Natl Health Stat Rep. 2009:1–25.

  56. Hultcrantz E, Ericsson E. Factors influencing the indication for tonsillectomy: a historical overview and current concepts. ORL J Otorhinolaryngol Relat Spec. 2013;75(3):184–91. https://doi.org/10.1159/000342322.

    Article  PubMed  Google Scholar 

  57. Borgstrom A, Nerfeldt P, Friberg D, et al. Trends and changes in paediatric tonsil surgery in Sweden 1987-2013: a population-based cohort study. BMJ Open. 2017;7:e013346.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Patel HH, Straight CE, Lehman EB, et al. Indications for tonsillectomy: a 10 year retrospective review. Int J Pediatr Otorhinolaryngol. 2014;78(12):2151–5. https://doi.org/10.1016/j.ijporl.2014.09.030.

    Article  PubMed  Google Scholar 

  59. Parker NP, Walner DL. Trends in the indications for pediatric tonsillectomy or adenotonsillectomy. Int J Pediatr Otorhinolaryngol. 2011;75(2):282–5. https://doi.org/10.1016/j.ijporl.2010.11.019.

    Article  PubMed  Google Scholar 

  60. Venekamp RP, Hearne BJ, Chandrasekharan D et al. Tonsillectomy or adenotonsillectomy versus non-surgical management for obstructive sleep-disordered breathing in children. Cochrane Database Syst Rev. 2015:CD011165.

  61. Marcus CL, Moore RH, Rosen CL, et al. A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med. 2013;368(25):2366–76. https://doi.org/10.1056/NEJMoa1215881.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Redline S, Amin R, Beebe D, Chervin RD, Garetz SL, Giordani B, et al. The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population. Sleep. 2011;34(11):1509–17. https://doi.org/10.5665/sleep.1388.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Sudarsan SS, Paramasivan VK, Arumugam SV, Murali S, Kameswaran M. Comparison of treatment modalities in syndromic children with obstructive sleep apnea—a randomized cohort study. Int J Pediatr Otorhinolaryngol. 2014;78(9):1526–33. https://doi.org/10.1016/j.ijporl.2014.06.027.

    Article  PubMed  Google Scholar 

  64. Goldstein NA, Pugazhendhi V, Rao SM, Weedon J, Campbell TF, Goldman AC, et al. Clinical assessment of pediatric obstructive sleep apnea. Pediatrics. 2004;114(1):33–43. https://doi.org/10.1542/peds.114.1.33.

    Article  PubMed  Google Scholar 

  65. Cheng J, Elden L. Outcomes in children under 12 months of age undergoing adenotonsillectomy for sleep-disordered breathing. Laryngoscope. 2013;123(9):2281–4. https://doi.org/10.1002/lary.23796.

    Article  PubMed  Google Scholar 

  66. Acevedo JL, Shah RK, Brietzke SE. Systematic review of complications of tonsillotomy versus tonsillectomy. Otolaryngol Head Neck Surg. 2012;146(6):871–9. https://doi.org/10.1177/0194599812439017.

    Article  PubMed  Google Scholar 

  67. •• Hoey AW, Foden NM, Hadjisymeou Andreou S, Noonan F, Chowdhury AK, Greig SR, et al. Coblation(R) intracapsular tonsillectomy (tonsillotomy) in children: a prospective study of 500 consecutive cases with long-term follow-up. Clin Otolaryngol. 2017. Important large study of Coblation intracapsular tonsillectomy in chidren.;42(6):1211–7. https://doi.org/10.1111/coa.12849.

    Article  CAS  PubMed  Google Scholar 

  68. Lowe D, van der Meulen J, Cromwell D, et al. Key messages from the National Prospective Tonsillectomy Audit. Laryngoscope. 2007;117:717–24.

    Article  PubMed  Google Scholar 

  69. Shah UK, Theroux Z, Shah GB, et al. Resource analysis of tonsillectomy in children. Laryngoscope. 2014;124(5):1223–8. https://doi.org/10.1002/lary.24388.

    Article  PubMed  Google Scholar 

  70. Marino A, Ranieri R, Chiarotti F, et al. Rapid maxillary expansion in children with obstructive sleep apnoea syndrome (OSAS). Eur J Paediatr Dent. 2012;13:57–63.

    Article  CAS  PubMed  Google Scholar 

  71. Kadouch DJ, Maas SM, Dubois L, van der Horst CM. Surgical treatment of macroglossia in patients with Beckwith-Wiedemann syndrome: a 20-year experience and review of the literature. Int J Oral Maxillofac Surg. 2012;41(3):300–8. https://doi.org/10.1016/j.ijom.2011.10.021.

    Article  CAS  PubMed  Google Scholar 

  72. Sisson TR, Whalen LE, Telek A. The blood volume of infants. II. The premature infant during the first year of life. J Pediatr. 1959;55:430–46.

    Article  CAS  PubMed  Google Scholar 

  73. Windfuhr JP. Serious complications following tonsillectomy: how frequent are they really? ORL J Otorhinolaryngol Relat Spec. 2013;75:166–73.

    Article  PubMed  Google Scholar 

  74. • Andropoulos DB, Greene MF. Anesthesia and developing brains—implications of the FDA warning. N Engl J Med. 2017;376(10):905–7. Good overview of the current understanding of general anesthesia exposure and neurocognitive outcomes. https://doi.org/10.1056/NEJMp1700196.

    Article  PubMed  Google Scholar 

  75. Armstrong R, Xu F, Arora A, Rasic N, Syed NI. General anesthetics and cytotoxicity: possible implications for brain health. Drug Chem Toxicol. 2017;40(2):241–9. https://doi.org/10.1080/01480545.2016.1188306.

    Article  CAS  PubMed  Google Scholar 

  76. Fodale V, Tripodi VF, Penna O, Famà F, Squadrito F, Mondello E, et al. An update on anesthetics and impact on the brain. Expert Opin Drug Saf. 2017;16(9):997–1008. https://doi.org/10.1080/14740338.2017.1351539.

    Article  PubMed  Google Scholar 

  77. Rappaport BA, Suresh S, Hertz S, et al. Anesthetic neurotoxicity—clinical implications of animal models. N Engl J Med. 2015;372:796–7.

    Article  CAS  PubMed  Google Scholar 

  78. •• Sun LS, Li G, Miller TL, et al. Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood. JAMA. 2016;315:2312–20. Important, recent. well-designed study investigating the effect of general anesthesia exposure before 36 months and neurocognitive outcomes.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Mann GE, Kahana M. The uncomfortable reality ... We simply do not know if general anesthesia negatively impacts the neurocognitive development of our small children. Int J Pediatr Otorhinolaryngol. 2015;79(9):1379–81. https://doi.org/10.1016/j.ijporl.2015.05.011.

    Article  PubMed  Google Scholar 

  80. Sanders RD, Hassell J, Davidson AJ, et al. Impact of anaesthetics and surgery on neurodevelopment: an update. Br J Anaesth. 2013;110(Suppl 1):i53–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Youshani AS, Thomas L, Sharma RK. Day case tonsillectomy for the treatment of obstructive sleep apnoea syndrome in children: Alder Hey experience. Int J Pediatr Otorhinolaryngol. 2011;75(2):207–10. https://doi.org/10.1016/j.ijporl.2010.10.036.

    Article  PubMed  Google Scholar 

  82. ME MC, Sheyn A, Haupert M, et al. Predicting complications after adenotonsillectomy in children 3 years old and younger. Int J Pediatr Otorhinolaryngol. 2011;75:1391–4.

    Article  Google Scholar 

  83. Waters KA, Chawla J, Harris MA, et al. Rationale for and design of the “POSTA” study: evaluation of neurocognitive outcomes after immediate adenotonsillectomy compared to watchful waiting in preschool children. BMC Pediatr. 2017;17:47.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Primhak R, Kingshott R. Sleep physiology and sleep-disordered breathing: the essentials. Arch Dis Child. 2012;97(1):54–8. https://doi.org/10.1136/adc.2010.186676.

    Article  PubMed  Google Scholar 

  85. Ramgopal S, Kothare SV, Rana M, Singh K, Khatwa U. Obstructive sleep apnea in infancy: a 7-year experience at a pediatric sleep center. Pediatr Pulmonol. 2014;49(6):554–60. https://doi.org/10.1002/ppul.22867.

    Article  PubMed  Google Scholar 

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Powell, J., Powell, S. Obstructive Sleep Apnea in the Very Young. Curr Otorhinolaryngol Rep 6, 48–55 (2018). https://doi.org/10.1007/s40136-018-0184-6

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